Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Petra Breiden"'
Autor:
Torben Johann Hausrat, Philipp C. Janiesch, Petra Breiden, David Lutz, Sabine Hoffmeister-Ullerich, Irm Hermans-Borgmeyer, Antonio Virgilio Failla, Matthias Kneussel
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Pathologic oligomerization of hyper-phosphorylated Tau is a hallmark of tauopathies. Here the authors show that the loss of tubulin a4 polyglutamylation reverses tau hyperphosphorylation, oligomerization and microglia activation in a tauopathy mouse.
Externí odkaz:
https://doaj.org/article/367d62fa69be4ed780bacc6d31c50491
Autor:
Mary Muhia, PingAn YuanXiang, Jan Sedlacik, Jürgen R. Schwarz, Frank F. Heisler, Kira V. Gromova, Edda Thies, Petra Breiden, Yvonne Pechmann, Michael R. Kreutz, Matthias Kneussel
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-18 (2022)
A murine muskelin knockout induces increased exploratory drive and alters cognition and functional connectivity. These effects correlate with actin-dependent changes in dendritic branching, spine structure, and AMPAR-mediated synaptic transmission.
Externí odkaz:
https://doaj.org/article/2a57e15d62354e63a3239b6cceda15bf
Autor:
André T Lopes, Torben J Hausrat, Frank F Heisler, Kira V Gromova, Franco L Lombino, Timo Fischer, Laura Ruschkies, Petra Breiden, Edda Thies, Irm Hermans-Borgmeyer, Michaela Schweizer, Jürgen R Schwarz, Christian Lohr, Matthias Kneussel
Publikováno v:
PLoS Biology, Vol 18, Iss 8, p e3000820 (2020)
Mutations in the gene encoding the microtubule-severing protein spastin (spastic paraplegia 4 [SPG4]) cause hereditary spastic paraplegia (HSP), associated with neurodegeneration, spasticity, and motor impairment. Complicated forms (complicated HSP [
Externí odkaz:
https://doaj.org/article/fd94a10cc9314b0d9d95e7c1e309a73e
Publikováno v:
Developmental Neurobiology. 81:333-350
Alpha- and beta-tubulin dimers polymerize into protofilaments that associate laterally to constitute a hollow tube, the microtubule. A dynamic network of interlinking filaments forms the microtubule cytoskeleton, which maintains the structure of cell
Autor:
Torben Johann Hausrat, Philipp C. Janiesch, Petra Breiden, David Lutz, Sabine Hoffmeister-Ullerich, Irm Hermans-Borgmeyer, Antonio Virgilio Failla, Matthias Kneussel
Publikováno v:
Nature communications. 13(1)
Dissociation of hyper-phosphorylated Tau from neuronal microtubules and its pathological aggregates, are hallmarks in the etiology of tauopathies. The Tau-microtubule interface is subject to polyglutamylation, a reversible posttranslational modificat
Publikováno v:
Developmental Neurobiology. 81
Autor:
Jürgen R. Schwarz, Michaela Schweizer, Kira V. Gromova, Timo Fischer, Frank F. Heisler, Torben J. Hausrat, Franco L. Lombino, Christian Lohr, Irm Hermans-Borgmeyer, André T. Lopes, Petra Breiden, Edda Thies, Laura Ruschkies, Matthias Kneussel
Publikováno v:
PLoS Biology
PLoS Biology, Vol 18, Iss 8, p e3000820 (2020)
PLoS Biology, Vol 18, Iss 8, p e3000820 (2020)
Mutations in the gene encoding the microtubule-severing protein spastin (spastic paraplegia 4 [SPG4]) cause hereditary spastic paraplegia (HSP), associated with neurodegeneration, spasticity, and motor impairment. Complicated forms (complicated HSP [
Autor:
Christian Lohr, Louisa Rathgeber, Kira V. Gromova, Irina Schaefer, Matthias Kneussel, Petra Breiden
Publikováno v:
European Journal of Cell Biology. 94:173-178
The kinesin KIF5 transports neuronal cargoes into axons and dendrites. Isolated KIF5 motor domains preferentially move into axons, however KIF5 binding to GRIP1 or gephyrin drives the motor into dendrites, to deliver AMPA receptors (AMPARs) or glycin
Autor:
Frank F. Heisler, Sachiko Tsukita, Trevor G. Smart, Torben J. Hausrat, Wiebke Hirdes, Joram Feldon, Matthias Kneussel, Petra Breiden, Mary Muhia, Jürgen R. Schwarz, Kimberly Gerrow, Philip Thomas, Lena Herich, Sylvain Dubroqua, Antoine Triller, Benjamin K. Yee
Publikováno v:
Nature Communications, 6
Nature Communications
Nature Communications
Neurotransmitter receptor density is a major variable in regulating synaptic strength. Receptors rapidly exchange between synapses and intracellular storage pools through endocytic recycling. In addition, lateral diffusion and confinement exchanges s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::626dfc08c8e6b086720200bdf0e5a756
https://hdl.handle.net/20.500.11850/100979
https://hdl.handle.net/20.500.11850/100979
Autor:
Maxim Bester, Mireia Sospedra, Andreas Sputtek, Stefanie Reinhardt, Petra Breiden, Stephen D. Miller, Roland Martin, Christoph Heesen, Andreas Lutterotti, Christian Schulze, Klarissa Hanja Stürner, Sven Schippling, Sara Yousef, Jan Patrick Stellmann
Publikováno v:
Science Translational Medicine. 5
Multiple sclerosis (MS) is a devastating inflammatory disease of the brain and spinal cord that is thought to result from an autoimmune attack directed against antigens in the central nervous system. The aim of this first-in-man trial was to assess t