Investigating peripheral blood monocyte and T-cell subsets as non-invasive biomarkers for asymptomatic hepatic steatosis: results from the Multi-Ethnic Study of Atherosclerosis

Autor: Rhys W. Niedecker, Joseph A. Delaney, Margaret F. Doyle, Andrew D. Sparks, Colleen M. Sitlani, Petra Buzkova, Irfan Zeb, Russell P. Tracy, Bruce M. Psaty, Matthew J. Budoff, Nels C. Olson

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

BackgroundCirculating immune cells have gained interest as biomarkers of hepatic steatosis. Data on the relationships between immune cell subsets and early-stage steatosis in population-based cohorts are limited.MethodsThis study included 1,944 asymp

Externí odkaz: https://doaj.org/article/a89e965518b34db585cca8b841d39fc6

Association of immune cell subsets with incident heart failure in two population‐based cohorts

Autor: Arjun Sinha, Colleen M. Sitlani, Margaret F. Doyle, Alison E. Fohner, Petra Buzkova, James S. Floyd, Sally A. Huber, Nels C. Olson, Joyce N. Njoroge, Jorge R. Kizer, Joseph A. Delaney, Sanjiv S. Shah, Russell P. Tracy, Bruce Psaty, Matthew Feinstein

Publikováno v: ESC Heart Failure, Vol 9, Iss 6, Pp 4177-4188 (2022)

Abstract Aims Circulating inflammatory markers are associated with incident heart failure (HF), but prospective data on associations of immune cell subsets with incident HF are lacking. We determined the associations of immune cell subsets with incid

Externí odkaz: https://doaj.org/article/cd5a7593a71e467a9aaa6a00d054f8db

Associations of Serum Nonesterified Fatty Acids With Coronary Heart Disease Mortality and Nonfatal Myocardial Infarction: The CHS (Cardiovascular Health Study) Cohort

Autor: Neil K. Huang, Petra Bůžková, Nirupa R. Matthan, Luc Djoussé, Calvin H. Hirsch, Jorge R. Kizer, W. T. Longstreth, Kenneth J. Mukamal, Alice H. Lichtenstein

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 6 (2021)

Background Significant associations have been reported between serum total nonesterified fatty acid (NEFA) concentrations and coronary heart disease (CHD) mortality and incident nonfatal myocardial infarction (MI) in some prospective cohort studies.

Externí odkaz: https://doaj.org/article/89305513c4f4404eaad2cf0c28c2d05d

A phenome-wide association study (PheWAS) in the Population Architecture using Genomics and Epidemiology (PAGE) study reveals potential pleiotropy in African Americans.

Autor: Sarah A Pendergrass, Steven Buyske, Janina M Jeff, Alex Frase, Scott Dudek, Yuki Bradford, Jose-Luis Ambite, Christy L Avery, Petra Buzkova, Ewa Deelman, Megan D Fesinmeyer, Christopher Haiman, Gerardo Heiss, Lucia A Hindorff, Chun-Nan Hsu, Rebecca D Jackson, Yi Lin, Loic Le Marchand, Tara C Matise, Kristine R Monroe, Larry Moreland, Kari E North, Sungshim L Park, Alex Reiner, Robert Wallace, Lynne R Wilkens, Charles Kooperberg, Marylyn D Ritchie, Dana C Crawford

Publikováno v: PLoS ONE, Vol 14, Iss 12, p e0226771 (2019)

We performed a hypothesis-generating phenome-wide association study (PheWAS) to identify and characterize cross-phenotype associations, where one SNP is associated with two or more phenotypes, between thousands of genetic variants assayed on the Meta

Externí odkaz: https://doaj.org/article/d1011295931b4e4fb3037f3c735bbbb4

Trans-ethnic fine-mapping of lipid loci identifies population-specific signals and allelic heterogeneity that increases the trait variance explained.

Autor: Ying Wu, Lindsay L Waite, Anne U Jackson, Wayne H-H Sheu, Steven Buyske, Devin Absher, Donna K Arnett, Eric Boerwinkle, Lori L Bonnycastle, Cara L Carty, Iona Cheng, Barbara Cochran, Damien C Croteau-Chonka, Logan Dumitrescu, Charles B Eaton, Nora Franceschini, Xiuqing Guo, Brian E Henderson, Lucia A Hindorff, Eric Kim, Leena Kinnunen, Pirjo Komulainen, Wen-Jane Lee, Loic Le Marchand, Yi Lin, Jaana Lindström, Oddgeir Lingaas-Holmen, Sabrina L Mitchell, Narisu Narisu, Jennifer G Robinson, Fred Schumacher, Alena Stančáková, Jouko Sundvall, Yun-Ju Sung, Amy J Swift, Wen-Chang Wang, Lynne Wilkens, Tom Wilsgaard, Alicia M Young, Linda S Adair, Christie M Ballantyne, Petra Bůžková, Aravinda Chakravarti, Francis S Collins, David Duggan, Alan B Feranil, Low-Tone Ho, Yi-Jen Hung, Steven C Hunt, Kristian Hveem, Jyh-Ming J Juang, Antero Y Kesäniemi, Johanna Kuusisto, Markku Laakso, Timo A Lakka, I-Te Lee, Mark F Leppert, Tara C Matise, Leena Moilanen, Inger Njølstad, Ulrike Peters, Thomas Quertermous, Rainer Rauramaa, Jerome I Rotter, Jouko Saramies, Jaakko Tuomilehto, Matti Uusitupa, Tzung-Dau Wang, Michael Boehnke, Christopher A Haiman, Yii-Der I Chen, Charles Kooperberg, Themistocles L Assimes, Dana C Crawford, Chao A Hsiung, Kari E North, Karen L Mohlke

Publikováno v: PLoS Genetics, Vol 9, Iss 3, p e1003379 (2013)

Genome-wide association studies (GWAS) have identified ~100 loci associated with blood lipid levels, but much of the trait heritability remains unexplained, and at most loci the identities of the trait-influencing variants remain unknown. We conducte

Externí odkaz: https://doaj.org/article/7c2f637f03e140f7b69972b2a24b3451