Zobrazeno 1 - 10 of 39 pro vyhledávání: '"Petra B, Musholt"'
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Akademický článek
Genetic analysis of blood molecular phenotypes reveals common properties in the regulatory networks affecting complex traits
Autor: Andrew A. Brown, Juan J. Fernandez-Tajes, Mun-gwan Hong, Caroline A. Brorsson, Robert W. Koivula, David Davtian, Théo Dupuis, Ambra Sartori, Theodora-Dafni Michalettou, Ian M. Forgie, Jonathan Adam, Kristine H. Allin, Robert Caiazzo, Henna Cederberg, Federico De Masi, Petra J. M. Elders, Giuseppe N. Giordano, Mark Haid, Torben Hansen, Tue H. Hansen, Andrew T. Hattersley, Alison J. Heggie, Cédric Howald, Angus G. Jones, Tarja Kokkola, Markku Laakso, Anubha Mahajan, Andrea Mari, Timothy J. McDonald, Donna McEvoy, Miranda Mourby, Petra B. Musholt, Birgitte Nilsson, Francois Pattou, Deborah Penet, Violeta Raverdy, Martin Ridderstråle, Luciana Romano, Femke Rutters, Sapna Sharma, Harriet Teare, Leen ‘t Hart, Konstantinos D. Tsirigos, Jagadish Vangipurapu, Henrik Vestergaard, Søren Brunak, Paul W. Franks, Gary Frost, Harald Grallert, Bernd Jablonka, Mark I. McCarthy, Imre Pavo, Oluf Pedersen, Hartmut Ruetten, Mark Walker, The DIRECT Consortium, Jerzy Adamski, Jochen M. Schwenk, Ewan R. Pearson, Emmanouil T. Dermitzakis, Ana Viñuela
Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract We evaluate the shared genetic regulation of mRNA molecules, proteins and metabolites derived from whole blood from 3029 human donors. We find abundant allelic heterogeneity, where multiple variants regulate a particular molecular phenotype,
Externí odkaz: https://doaj.org/article/03b888dddec54ecd93647492ab5dd5aa
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2
Akademický článek
Whole blood co-expression modules associate with metabolic traits and type 2 diabetes: an IMI-DIRECT study
Autor: Valborg Gudmundsdottir, Helle Krogh Pedersen, Gianluca Mazzoni, Kristine H. Allin, Anna Artati, Joline W. Beulens, Karina Banasik, Caroline Brorsson, Henna Cederberg, Elizaveta Chabanova, Federico De Masi, Petra J. Elders, Ian Forgie, Giuseppe N. Giordano, Harald Grallert, Ramneek Gupta, Mark Haid, Torben Hansen, Tue H. Hansen, Andrew T. Hattersley, Alison Heggie, Mun-Gwan Hong, Angus G. Jones, Robert Koivula, Tarja Kokkola, Markku Laakso, Peter Løngreen, Anubha Mahajan, Andrea Mari, Timothy J. McDonald, Donna McEvoy, Petra B. Musholt, Imre Pavo, Cornelia Prehn, Hartmut Ruetten, Martin Ridderstråle, Femke Rutters, Sapna Sharma, Roderick C. Slieker, Ali Syed, Juan Fernandez Tajes, Cecilia Engel Thomas, Henrik S. Thomsen, Jagadish Vangipurapu, Henrik Vestergaard, Ana Viñuela, Agata Wesolowska-Andersen, Mark Walker, Jerzy Adamski, Jochen M. Schwenk, Mark I. McCarthy, Ewan Pearson, Emmanouil Dermitzakis, Paul W. Franks, Oluf Pedersen, Søren Brunak
Publikováno v: Genome Medicine, Vol 12, Iss 1, Pp 1-17 (2020)
Abstract Background The rising prevalence of type 2 diabetes (T2D) poses a major global challenge. It remains unresolved to what extent transcriptomic signatures of metabolic dysregulation and T2D can be observed in easily accessible tissues such as
Externí odkaz: https://doaj.org/article/f4c2d5133478495aa5b959e30078db0a
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3
Akademický článek
Short-term variability of the human serum metabolome depending on nutritional and metabolic health status
Autor: Inoncent Agueusop, Petra B. Musholt, Beate Klaus, Kendra Hightower, Aimo Kannt
Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Abstract The intra-individual variability of the human serum metabolome over a period of 4 weeks and its dependence on metabolic health and nutritional status was investigated in a single-center study under tightly controlled conditions in healthy co
Externí odkaz: https://doaj.org/article/af2daeff5b9c45e18f466140866829f2
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4
Akademický článek
Predicting and elucidating the etiology of fatty liver disease: A machine learning modeling and validation study in the IMI DIRECT cohorts.
Autor: Naeimeh Atabaki-Pasdar, Mattias Ohlsson, Ana Viñuela, Francesca Frau, Hugo Pomares-Millan, Mark Haid, Angus G Jones, E Louise Thomas, Robert W Koivula, Azra Kurbasic, Pascal M Mutie, Hugo Fitipaldi, Juan Fernandez, Adem Y Dawed, Giuseppe N Giordano, Ian M Forgie, Timothy J McDonald, Femke Rutters, Henna Cederberg, Elizaveta Chabanova, Matilda Dale, Federico De Masi, Cecilia Engel Thomas, Kristine H Allin, Tue H Hansen, Alison Heggie, Mun-Gwan Hong, Petra J M Elders, Gwen Kennedy, Tarja Kokkola, Helle Krogh Pedersen, Anubha Mahajan, Donna McEvoy, Francois Pattou, Violeta Raverdy, Ragna S Häussler, Sapna Sharma, Henrik S Thomsen, Jagadish Vangipurapu, Henrik Vestergaard, Leen M 't Hart, Jerzy Adamski, Petra B Musholt, Soren Brage, Søren Brunak, Emmanouil Dermitzakis, Gary Frost, Torben Hansen, Markku Laakso, Oluf Pedersen, Martin Ridderstråle, Hartmut Ruetten, Andrew T Hattersley, Mark Walker, Joline W J Beulens, Andrea Mari, Jochen M Schwenk, Ramneek Gupta, Mark I McCarthy, Ewan R Pearson, Jimmy D Bell, Imre Pavo, Paul W Franks
Publikováno v: PLoS Medicine, Vol 17, Iss 6, p e1003149 (2020)
BackgroundNon-alcoholic fatty liver disease (NAFLD) is highly prevalent and causes serious health complications in individuals with and without type 2 diabetes (T2D). Early diagnosis of NAFLD is important, as this can help prevent irreversible damage
Externí odkaz: https://doaj.org/article/a99f2812d7bb4af9aa894b7e0bf320bd
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6
Gut Mucosal Gene Expression and Metabolic Changes After Roux‐en‐Y Gastric Bypass Surgery
Autor: Kristoffer T.G. Rigbolt, Frederik Helgstrand, Jens F. Rehfeld, Ebbe Langholz, Claus B. Juhl, Torben Østergaard, Niels Vrang, Chen Zhang, Brynjulf Mortensen, Philip J. Larsen, Marie M. Christensen, Erik Wandall, Mechthilde Falkenhahn, Frederik Sørensen, Stefan Theis, René Klinkby Støving, Julie Lyng Forman, Petra B. Musholt, Torsten Schmidt, Filip K. Knop, Thomas Rydborg, Tina Jorsal, Steffen U. Friis, Tina Vilsbøll, Alin R. Aldries, Jacob Jelsing, Andrea Karen Floyd, Eva B. Nygaard, Dorte Worm
Publikováno v: Jorsal, T, Christensen, M M, Mortensen, B, Nygaard, E B, Zhang, C, Rigbolt, K, Wandall, E, Langholz, E, Friis, S, Worm, D, Floyd, A, Helgstrand, F, Støving, R K, Aldries, A R, Juhl, C B, Østergaard, T, Rydborg, T, Forman, J L, Sørensen, F, Schmidt, T, Falkenhahn, M, Musholt, P B, Theis, S, Larsen, P J, Rehfeld, J F, Vrang, N, Jelsing, J, Vilsbøll, T & Knop, F K 2020, ' Gut Mucosal Gene Expression and Metabolic Changes After Roux-en-Y Gastric Bypass Surgery ', Obesity, vol. 28, no. 11, pp. 2163-2174 . https://doi.org/10.1002/oby.22973
OBJECTIVE: Changes in the secretion of gut-derived peptide hormones have been associated with the metabolic benefits of Roux-en-Y gastric bypass (RYGB) surgery. In this study, the effects of RYGB on anthropometrics, postprandial plasma hormone respon
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dd8729e918cb8f82b6c6852066cbdc2
https://doi.org/10.1002/oby.22973
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7
Investigating Intestinal Glucagon After Roux-en-Y Gastric Bypass Surgery
Autor: Erik Wandall, Mechthilde Falkenhahn, Claus B. Juhl, Marie M. Christensen, Nicolai J. Wewer Albrechtsen, Filip K. Knop, Tina Jorsal, Steffen U. Friis, Alin Andries, Niels Vrang, Brynjulf Mortensen, Philip J. Larsen, Ebbe Langholz, Petra B. Musholt, Tina Vilsbøll, Frederik Sørensen, Dorte Worm, René Klinkby Støving, Stefan Theis, Cathrine Ørskov, Jacob Jelsing, Julie Lyng Forman, Jens J. Holst
Publikováno v: Jorsal, T, Wewer Albrechtsen, N J, Christensen, M M, Mortensen, B, Wandall, E, Langholz, E, Friis, S, Worm, D, Ørskov, C, Støving, R K, Andries, A, Juhl, C B, Sørensen, F, Forman, J L, Falkenhahn, M, Musholt, P B, Theis, S, Larsen, P J, Holst, J J, Vrang, N, Jelsing, J, Vilsbøll, T & Knop, F K 2019, ' Investigating Intestinal Glucagon after Roux-en-Y Gastric Bypass Surgery ', Journal of Clinical Endocrinology and Metabolism, vol. 104, no. 12, pp. 6403–6416 . https://doi.org/10.1210/jc.2019-00062
Jorsal, T, Wewer Albrechtsen, N J, Christensen, M M, Mortensen, B, Wandall, E, Langholz, E, Friis, S, Worm, D, Ørskov, C, Støving, R K, Andries, A, Juhl, C B, Sørensen, F, Forman, J L, Falkenhahn, M, Musholt, P B, Theis, S, Larsen, P J, Holst, J J, Vrang, N, Jelsing, J, Vilsbøll, T & Knop, F K 2019, ' Investigating Intestinal Glucagon after Roux-en-Y Gastric Bypass Surgery ', The Journal of clinical endocrinology and metabolism, vol. 104, no. 12, pp. 6403-6416 . https://doi.org/10.1210/jc.2019-00062
BASE-Bielefeld Academic Search Engine
Context After Roux-en-Y gastric bypass (RYGB) surgery, postprandial plasma glucagon concentrations have been reported to increase. This occurs despite concomitant improved glucose tolerance and increased circulating plasma concentrations of insulin a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::308107e9d82aa520a7f4c7ab280e753a
https://doi.org/10.1210/jc.2019-00062
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8
Processes Underlying Glycemic Deterioration in Type 2 Diabetes: An IMI DIRECT Study
Autor: Petra J. M. Elders, Hartmut Ruetten, Tarja Kokkola, Andrew T. Hattersley, Tue H. Hansen, Jane Kaye, Robert W. Koivula, Kristine H. Allin, Agnete T. Lundgaard, Martin Ridderstråle, Konstantinos D. Tsirigos, Joline W. Beulens, Emmanouil T. Dermitzakis, E. Louise Thomas, Jochen M. Schwenk, Roberto Bizzotto, Torben Hansen, Christopher Jennison, Imre Pavo, Mark Walker, Henrik Vestergaard, Paul W. Franks, Anubha Mahajan, Ana Viñuela, Søren Brunak, Andrea Tura, Henrik S. Thomsen, Petra B. Musholt, Ian M Forgie, Timothy J. McDonald, Ewan R. Pearson, Gary Frost, Oluf Pedersen, Federico De Masi, Andrea Mari, Jerzy Adamski, Leen M 't Hart, Alison Heggie, Soren Brage, Gwen Kennedy, Rebeca Eriksen, Giuseppe N. Giordano, Azra Kurbasic, Jimmy D. Bell, Donna McEvoy, Mark I. McCarthy, Angus G. Jones
Publikováno v: Diabetes Care, 44(2), 511-518. American Diabetes Association Inc.
Diabetes Care, 44(2), 511-518. AMER DIABETES ASSOC
2021, ' Processes Underlying Glycemic Deterioration in Type 2 Diabetes : An IMI DIRECT Study ', Diabetes Care, vol. 44, no. 2, pp. 511-518 . https://doi.org/10.2337/dc20-1567
IMI DIRECT Consortium 2021, ' Processes Underlying Glycemic Deterioration in Type 2 Diabetes: An IMI DIRECT Study ', Diabetes Care, vol. 44, no. 2, pp. 511-518 . https://doi.org/10.2337/dc20-1567
OBJECTIVE We investigated the processes underlying glycemic deterioration in type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS A total of 732 recently diagnosed patients with T2D from the Innovative Medicines Initiative Diabetes Research on Patient
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::154913efb800505483b5b43ee16cf6b2
https://research.vumc.nl/en/publications/2549dde0-dd25-485d-9f9e-bc8dc8f5ba96
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10
Whole blood co-expression modules associate with metabolic traits and type 2 diabetes : an IMI-DIRECT study
Autor: Mark Walker, Ramneek Gupta, Cecilia Engel Thomas, Mun-Gwan Hong, Femke Rutters, Tarja Kokkola, Andrew T. Hattersley, Ali Syed, Andrea Mari, Elizaveta Chabanova, Joline W.J. Beulens, Helle Krogh Pedersen, Henna Cederberg, Petra J. M. Elders, Torben Hansen, Tue H. Hansen, Caroline Brorsson, Jerzy Adamski, Harald Grallert, Jagadish Vangipurapu, Karina Banasik, Emmanouil T. Dermitzakis, Agata Wesolowska-Andersen, Henrik S. Thomsen, Juan Fernandez Tajes, Donna McEvoy, Valborg Gudmundsdottir, Jochen M. Schwenk, Gianluca Mazzoni, Kristine H. Allin, Ian M Forgie, Søren Brunak, Petra B. Musholt, Timothy J. McDonald, Henrik Vestergaard, Federico De Masi, Cornelia Prehn, Ana Viñuela, Martin Ridderstråle, Roderick C. Slieker, Alison Heggie, Giuseppe N. Giordano, Ewan R. Pearson, Oluf Pedersen, Anna Artati, Mark Haid, Peter Løngreen, Markku Laakso, Imre Pavo, Paul W. Franks, Mark I. McCarthy, Angus G. Jones, Hartmut Ruetten, Robert W. Koivula, Sapna Sharma, Anubha Mahajan
Publikováno v: Gudmundsdottir, V, Pedersen, H K, Mazzoni, G, Allin, K H, Artati, A, Beulens, J W, Banasik, K, Brorsson, C, Cederberg, H, Chabanova, E, De Masi, F, Elders, P J, Forgie, I, Giordano, G N, Grallert, H, Gupta, R, Haid, M, Hansen, T, Hansen, T H, Hattersley, A T, Heggie, A, Hong, M G, Jones, A G, Koivula, R, Kokkola, T, Laakso, M, Løngreen, P, Mahajan, A, Mari, A, McDonald, T J, McEvoy, D, Musholt, P B, Pavo, I, Prehn, C, Ruetten, H, Ridderstråle, M, Rutters, F, Sharma, S, Slieker, R C, Syed, A, Tajes, J F, Thomas, C E, Thomsen, H S, Vangipurapu, J, Vestergaard, H, Viñuela, A, Wesolowska-Andersen, A, Walker, M, Adamski, J & Schwenk, J M 2020, ' Whole blood co-expression modules associate with metabolic traits and type 2 diabetes : an IMI-DIRECT study ', Genome Medicine, vol. 12, 109 . https://doi.org/10.1186/s13073-020-00806-6
Genome Med. 12:109 (2020)
Genome Medicine
Gudmundsdottir, V, Pedersen, H K, Mazzoni, G, Allin, K H, Artati, A, Beulens, J W, Banasik, K, Brorsson, C, Cederberg, H, Chabanova, E, De Masi, F, Elders, P J, Forgie, I, Giordano, G N, Grallert, H, Gupta, R, Haid, M, Hansen, T, Hansen, T H, Hattersley, A T, Heggie, A, Hong, M G, Jones, A G, Koivula, R, Kokkola, T, Laakso, M, Løngreen, P, Mahajan, A, Mari, A, McDonald, T J, McEvoy, D, Musholt, P B, Pavo, I, Prehn, C, Ruetten, H, Ridderstråle, M, Rutters, F, Sharma, S, Slieker, R C, Syed, A, Tajes, J F, Thomas, C E, Thomsen, H S, Vangipurapu, J, Vestergaard, H, Viñuela, A, Wesolowska-Andersen, A, Walker, M, Adamski, J, Schwenk, J M, McCarthy, M I, Pearson, E, Dermitzakis, E, Franks, P W, Pedersen, O & Brunak, S 2020, ' Whole blood co-expression modules associate with metabolic traits and type 2 diabetes : an IMI-DIRECT study ', Genome Medicine, vol. 12, no. 1, 109 . https://doi.org/10.1186/s13073-020-00806-6
Gudmundsdottir, V, Pedersen, H K, Mazzoni, G, Allin, K H, Artati, A, Beulens, J W, Banasik, K, Brorsson, C, Cederberg, H, Chabanova, E, de Masi, F, Elders, P J, Forgie, I, Giordano, G N, Grallert, H, Gupta, R, Haid, M, Hansen, T, Hansen, T H, Hattersley, A T, Heggie, A, Hong, M-G, Jones, A G, Koivula, R, Kokkola, T, Laakso, M, Løngreen, P, Mahajan, A, Mari, A, McDonald, T J, McEvoy, D, Musholt, P B, Pavo, I, Prehn, C, Ruetten, H, Ridderstråle, M, Rutters, F, Sharma, S, Slieker, R C, Syed, A, Tajes, J F, Thomas, C E, Thomsen, H S, Vangipurapu, J, Vestergaard, H, Viñuela, A, Wesolowska-Andersen, A, Walker, M, Adamski, J, Schwenk, J M, McCarthy, M I, Pearson, E, Dermitzakis, E, Franks, P W, Pedersen, O & Brunak, S R 2020, ' Whole blood co-expression modules associate with metabolic traits and type 2 diabetes: an IMI-DIRECT study ', Genome Medicine, vol. 12, no. 1, 109 . https://doi.org/10.1186/s13073-020-00806-6
Gudmundsdottir, V, Pedersen, H K, Mazzoni, G, Allin, K H, Artati, A, Beulens, J W, Banasik, K, Brorsson, C, Cederberg, H, Chabanova, E, De Masi, F, Elders, P J, Forgie, I, Giordano, G N, Grallert, H, Gupta, R, Haid, M, Hansen, T, Hansen, T H, Hattersley, A T, Heggie, A, Hong, M-G, Jones, A G, Koivula, R, Kokkola, T, Laakso, M, Løngreen, P, Mahajan, A, Mari, A, McDonald, T J, McEvoy, D, Musholt, P B, Pavo, I, Prehn, C, Ruetten, H, Ridderstrale, M, Rutters, F, Sharma, S, Slieker, R C, Syed, A, Tajes, J F, Thomas, C E, Thomsen, H S, Vangipurapu, J, Vestergaard, H, Vinuela, A, Wesolowska-Andersen, A, Walker, M, Adamski, J, Schwenk, J M, McCarthy, M, Pearson, E, Dermitzakis, E, Franks, P W, Pedersen, O & Brunak, S 2020, ' Whole blood co-expression modules associate with metabolic traits and type 2 diabetes : an IMI-DIRECT study ', Genome Medicine, vol. 12, no. 1, 109 . https://doi.org/10.1186/s13073-020-00806-6
Genome Medicine, 12(1):109. BioMed Central
Genome Medicine, Vol 12, Iss 1, Pp 1-17 (2020)
Genome Medicine, 12(1). BMC
BackgroundThe rising prevalence of type 2 diabetes (T2D) poses a major global challenge. It remains unresolved to what extent transcriptomic signatures of metabolic dysregulation and T2D can be observed in easily accessible tissues such as blood. Add
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e57df0fb1c8eb5c13cedd11bb0040340
http://hdl.handle.net/10138/324227
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