Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Petra S. Kern"'
Autor:
Petra S. Kern, Kim Ellingson, Yuan Gao, Nora L. Krutz, Kady Krivos, Mike Quijano, Yan Xu, Cindy A. Ryan
Publikováno v:
Toxicology in Vitro. 90:105591
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::216d1f8d7b6404f8a3b5db7d6fc726f0
https://doi.org/10.1016/j.tiv.2023.105591
https://doi.org/10.1016/j.tiv.2023.105591
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 135
In June 2021 the Organisation for Economic Co-operation and Development published Guideline No. 497 on Defined Approaches for Skin Sensitisation (DASS GL). There are two DAs published, known as the 2o3 and the ITS. The 2o3 uses two concordant results
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdf2bf8dee2765d63d249b8b342279ac
https://pubmed.ncbi.nlm.nih.gov/36007801
https://pubmed.ncbi.nlm.nih.gov/36007801
Autor:
Sebastian Hoffmann, Nathalie Alépée, Nicola Gilmour, Petra S. Kern, Erwin van Vliet, Fanny Boislève, Dagmar Bury, Elodie Cloudet, Martina Klaric, Jochen Kühnl, Jon F. Lalko, Karsten Mewes, Masaaki Miyazawa, Hayato Nishida, Mai Thanh Tam Brami, Mustafa Varçin, Anne Marie Api, Cosmetics Europe
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 131
The assessment of skin sensitisation is a key requirement in all regulated sectors, with the European Union's regulation of cosmetic ingredients being most challenging, since it requires quantitative skin sensitisation assessment based on new approac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67436f07a0169ef82f6ae0d2319ed98a
https://pubmed.ncbi.nlm.nih.gov/35447229
https://pubmed.ncbi.nlm.nih.gov/35447229
Autor:
Vithiagaran Gunalan, Nora L Krutz, Matthew Nguyen, Petra S. Kern, Frank Eisenhaber, Vachiranee Limviphuvadh, G. Frank Gerberick, Sebastian Maurer-Stroh
Publikováno v:
Bioinformatics
Motivation Due to the risk of inducing an immediate Type I (IgE-mediated) allergic response, proteins intended for use in consumer products must be investigated for their allergenic potential before introduction into the marketplace. The FAO/WHO guid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff5fb56a7012bccf7120ec587f677ada
https://doi.org/10.1093/bioinformatics/btz029
https://doi.org/10.1093/bioinformatics/btz029
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 182(2)
Interest in the development of methods to evaluate the respiratory sensitization potential of low-molecular weight chemicals continues, but no method has yet been generally accepted or validated. A lack of chemical reference standards, together with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6171ade73af8e87f507bed2201d2b228
https://pubmed.ncbi.nlm.nih.gov/34003265
https://pubmed.ncbi.nlm.nih.gov/34003265
Autor:
Mihwa Na, Devin O'Brien, G. Frank Gerberick, Petra S. Kern, Maura Lavelle, Isabelle Lee, Rahul Parakhia, Cindy Ryan, Anne Marie Api
Publikováno v:
Regulatory Toxicology and Pharmacology. 130:105128
Potency determination of potential skin sensitizers in humans is essential for quantitative risk assessment and proper risk management. SENS-IS is an in vitro test based on a reconstructed human skin model, that was developed to predict the hazard an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61a2102ee5b10027ca0897586200a027
https://doi.org/10.1016/j.yrtph.2022.105128
https://doi.org/10.1016/j.yrtph.2022.105128
Autor:
G. Frank Gerberick, Cindy A. Ryan, Thomas M Burt, John A. Troutman, Petra S. Kern, Roy L. M. Dobson, Hong Jian Dai, Mike Quijano
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 178(1)
A peptide reactivity assay with an activation component was developed for use in screening chemicals for skin sensitization potential. A horseradish peroxidase-hydrogen peroxide (HRP/P) oxidation system was incorporated into the assay for characteriz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14e11e64682e67efebf067fac22c138e
https://pubmed.ncbi.nlm.nih.gov/33094344
https://pubmed.ncbi.nlm.nih.gov/33094344
Autor:
Ian R. White, Alain Khaiat, Peter Griem, Benjamin P C Smith, Nicola Gilmour, David A. Basketter, Helmut Greim, Peter A. Cadby, Graham Ellis, A.M. Api, Thomas Rustemeyer, John O'Brien, Bob Safford, Petra S. Kern, Cindy A. Ryan, Matthias Vey, James W. Bridges
Publikováno v:
Api, A M, Basketter, D, Bridges, J, Cadby, P, Ellis, G, Gilmour, N, Greim, H, Griem, P, Kern, P, Khaiat, A, O'Brien, J, Rustemeyer, T, Ryan, C, Safford, B, Smith, B, Vey, M & White, I R 2020, ' Updating exposure assessment for skin sensitization quantitative risk assessment for fragrance materials ', Regulatory Toxicology and Pharmacology, vol. 118, 104805 . https://doi.org/10.1016/j.yrtph.2020.104805
Regulatory Toxicology and Pharmacology, 118:104805. Academic Press Inc.
Regulatory Toxicology and Pharmacology, 118:104805. Academic Press Inc.
In 2008, a proposal for assessing the risk of induction of skin sensitization to fragrance materials Quantitative Risk Assessment 1 (QRA1) was published. This was implemented for setting maximum limits for fragrance materials in consumer products. Ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ad42452a64d804f0517f1fa3af8578b
https://pubmed.ncbi.nlm.nih.gov/33075411
https://pubmed.ncbi.nlm.nih.gov/33075411
Autor:
Petra S. Kern, Kirstin Kosemund-Meynen, Maciej Stępnik, Christophe Rousselle, Natalie von Goetz, Janine Ezendam, Gladys Ouedraogo, Ulrike Bernauer, Emilio Benfenati, Mark T. D. Cronin, Carsten Goebel, Qasim Chaudhry, Paul L. Carmichael, Eric Gaffet, Pieter Jan Coenraads, Heli M. Hollnagel, Laurent Bodin, Berit Granum, Corrado L. Galli, Andrew Worth, Vera Rogiers, Matthew P. Dent, Maria Dusinska, Tamara Vanhaecke, Eirini Panteri, Corie A. Ellison
Publikováno v:
Toxicology
Toxicology, Elsevier, 2020, 436, pp.152421. ⟨10.1016/j.tox.2020.152421⟩
Toxicology, 2020, 436, pp.152421. ⟨10.1016/j.tox.2020.152421⟩
Toxicology, Elsevier, 2020, 436, pp.152421. ⟨10.1016/j.tox.2020.152421⟩
Toxicology, 2020, 436, pp.152421. ⟨10.1016/j.tox.2020.152421⟩
International audience; Although the need for non-animal alternatives has been well recognised for the human health hazard assessment of chemicals in general, it has become especially pressing for cosmetic ingredients due to the full implementation o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c96edc17a3c3d4598238bfda31dc339
https://doi.org/10.1016/j.tox.2020.152421
https://doi.org/10.1016/j.tox.2020.152421
Autor:
Barbara Birk, Marián Rucki, Sjoerd Verkaart, L. Nardelli, Tina Haupt, Hans Raabe, Andreas Natsch, Rishil Kathawala, Petra S. Kern, Robert Landsiedel, Cindy A. Ryan, Susanne N. Kolle, Nathalie Alépée, Walter M.A. Westerink, Britta Wareing
Publikováno v:
ALTEX. 37(4)
While the skin sensitization hazard of substances can be identified using non-animal methods, the classification of potency into UN GHS sub-categories 1A and 1B remains challenging. The kinetic direct peptide reactivity assay (kDPRA) is a modificatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98f4c2f9e64e6c36cd0e949cb1c65522
https://pubmed.ncbi.nlm.nih.gov/32521036
https://pubmed.ncbi.nlm.nih.gov/32521036