Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Petra, van der Lelij"'
Autor:
Gordana Wutz, Rene Ladurner, Brian Glenn St Hilaire, Roman R Stocsits, Kota Nagasaka, Benoit Pignard, Adrian Sanborn, Wen Tang, Csilla Várnai, Miroslav P Ivanov, Stefan Schoenfelder, Petra van der Lelij, Xingfan Huang, Gerhard Dürnberger, Elisabeth Roitinger, Karl Mechtler, Iain Finley Davidson, Peter Fraser, Erez Lieberman-Aiden, Jan-Michael Peters
Publikováno v:
eLife, Vol 9 (2020)
Eukaryotic genomes are folded into loops. It is thought that these are formed by cohesin complexes via extrusion, either until loop expansion is arrested by CTCF or until cohesin is removed from DNA by WAPL. Although WAPL limits cohesin’s chromatin
Externí odkaz:
https://doaj.org/article/50f9b518193c4de2ba8e04afd984547d
Werner syndrome helicase is a selective vulnerability of microsatellite instability-high tumor cells
Autor:
Simone Lieb, Silvia Blaha-Ostermann, Elisabeth Kamper, Janine Rippka, Cornelia Schwarz, Katharina Ehrenhöfer-Wölfer, Andreas Schlattl, Andreas Wernitznig, Jesse J Lipp, Kota Nagasaka, Petra van der Lelij, Gerd Bader, Minoru Koi, Ajay Goel, Ralph A Neumüller, Jan-Michael Peters, Norbert Kraut, Mark A Pearson, Mark Petronczki, Simon Wöhrle
Publikováno v:
eLife, Vol 8 (2019)
Targeted cancer therapy is based on exploiting selective dependencies of tumor cells. By leveraging recent functional screening data of cancer cell lines we identify Werner syndrome helicase (WRN) as a novel specific vulnerability of microsatellite i
Externí odkaz:
https://doaj.org/article/bcf5373f995c49dd883a2b357adfa700
Autor:
Ruud H. Brakenhoff, Stephan M. Feller, Hans Joenje, Bauke Ylstra, Jesper A. Balk, Ralf Dietrich, Arjen Brink, Saskia E. van Mil, Martin A. Rooimans, Anneke B. Oostra, Irsan E. Kooi, Petra van der Lelij, Najim Ameziane, Chantal Stoepker
Supplemental Material and Methods. Supplemental Figure S1. Cell cycle analysis in FA and sporadic HNSCC cell lines upon ICL treatment. Supplemental Figure S2. FANCM protein expression is absent in FaDu cells. Supplemental Figure S3. Overview of possi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3787e8371329b3552a21a7e7c61e5949
https://doi.org/10.1158/0008-5472.22405466
https://doi.org/10.1158/0008-5472.22405466
Autor:
Petra van der Lelij, Simone Lieb, Julian Jude, Gordana Wutz, Catarina P Santos, Katrina Falkenberg, Andreas Schlattl, Jozef Ban, Raphaela Schwentner, Thomas Hoffmann, Heinrich Kovar, Francisco X Real, Todd Waldman, Mark A Pearson, Norbert Kraut, Jan-Michael Peters, Johannes Zuber, Mark Petronczki
Publikováno v:
eLife, Vol 6 (2017)
Recent genome analyses have identified recurrent mutations in the cohesin complex in a wide range of human cancers. Here we demonstrate that the most frequently mutated subunit of the cohesin complex, STAG2, displays a strong synthetic lethal interac
Externí odkaz:
https://doaj.org/article/2300278a425a41e0beb781865da52db9
Autor:
Petra van der Lelij, Laura Santini, Henry Fabian Thomas, Meryem Ralser, Elena Galimberti, Mihail Sarov, Marius Garmhausen, Martin Leeb, Andreas Beyer, Giuliano Giuseppe Stirparo, A. Francis Stewart, Fabian Titz-Teixeira, Robert Sehlke, Julia Ramesmayer, Andreas Lackner, Michelle Huth, Austin Smith
Publikováno v:
The EMBO Journal
In the mammalian embryo, epiblast cells must exit the naïve state and acquire formative pluripotency. This cell state transition is recapitulated by mouse embryonic stem cells (ESCs), which undergo pluripotency progression in defined conditions in v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf0966c58bbd48ebd2a844aa6b6913cd
https://doi.org/10.15252/embj.2020105776
https://doi.org/10.15252/embj.2020105776
Autor:
Martin Leeb, Robert Sehlke, Petra van der Lelij, A. Francis Stewart, Marius Garmhausen, Mihail Sarov, Andreas Lackner, Henry Fabian Thomas, Julia Ramesmayer, Laura Santini, Andreas Beyer, Michelle Huth, Fabian Titz-Teixeira, Austin Smith, Giuliano Giuseppe Stirparo, Meryem Ralser
In the mammalian embryo, epiblast cells must exit their naïve state and acquire formative pluripotency. This cell state transition is recapitulated by mouse embryonic stem cells (ESCs), which undergo pluripotency progression in defined conditions in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4fae4c4df10a6b6c736e6c4a925f1289
https://doi.org/10.1101/2020.03.23.000109
https://doi.org/10.1101/2020.03.23.000109
Publikováno v:
Anemia, Vol 2010 (2010)
Fanconi anemia (FA) is a recessively inherited disease characterized by multiple symptoms including growth retardation, skeletal abnormalities, and bone marrow failure. The FA diagnosis is complicated due to the fact that the clinical manifestations
Externí odkaz:
https://doaj.org/article/386ffcc3026b41d48254c92664e3b0e5
Autor:
Petra van der Lelij, Barbara C Godthelp, Wouter van Zon, Djoke van Gosliga, Anneke B Oostra, Jûrgen Steltenpool, Jan de Groot, Rik J Scheper, Rob M Wolthuis, Quinten Waisfisz, Firouz Darroudi, Hans Joenje, Johan P de Winter
Publikováno v:
PLoS ONE, Vol 4, Iss 9, p e6936 (2009)
Cohesion between sister chromatids is essential for faithful chromosome segregation. In budding yeast, the acetyltransferase Eco1/Ctf7 establishes cohesion during DNA replication in S phase and in response to DNA double strand breaks in G2/M phase. I
Externí odkaz:
https://doaj.org/article/6f40772f89084249bf6e000aa539bed6
Autor:
Mark Petronczki, Jan-Michael Peters, Petra van der Lelij, V.L. Katis, Julian Jude, Thomas Hoffmann, Gerd Bader, Johannes Zuber, Matthias Hinterndorfer, Simone Lieb, Opher Gileadi, Mark Pearson, J.A. Newman, Norbert Kraut
Publikováno v:
Life Science Alliance
This work highlights the degradation of STAG1 and inhibition of its interaction with cohesin as promising therapeutic strategies for exploiting synthetic lethality to treat STAG2-mutated tumors and lays the groundwork for the discovery of STAG1-direc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ce548594eea9cf3b60b702945c16280
Autor:
Stefan Schoenfelder, Brian Glenn St Hilaire, Petra van der Lelij, Jan-Michael Peters, Wen Tang, Gordana Wutz, Karl Mechtler, Iain F. Davidson, Adrian L. Sanborn, Benoit Pignard, Miroslav P Ivanov, Roman R. Stocsits, Peter Fraser, Elisabeth Roitinger, Xingfan Huang, Erez Lieberman Aiden, Kota Nagasaka, Rene Ladurner, Gerhard Dürnberger, Csilla Várnai
Publikováno v:
eLife
eLife, Vol 9 (2020)
eLife, Vol 9 (2020)
Eukaryotic genomes are folded into loops. It is thought that these are formed by cohesin complexes via extrusion, either until loop expansion is arrested by CTCF or until cohesin is removed from DNA by WAPL. Although WAPL limits cohesin’s chromatin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3c4e248dc34f280439bceca79883c99