Zobrazeno 1 - 10
of 109
pro vyhledávání: '"Petra, Rümmele"'
Autor:
Melanie Werner-Klein, Ana Grujovic, Christoph Irlbeck, Milan Obradović, Martin Hoffmann, Huiqin Koerkel-Qu, Xin Lu, Steffi Treitschke, Cäcilia Köstler, Catherine Botteron, Kathrin Weidele, Christian Werno, Bernhard Polzer, Stefan Kirsch, Miodrag Gužvić, Jens Warfsmann, Kamran Honarnejad, Zbigniew Czyz, Giancarlo Feliciello, Isabell Blochberger, Sandra Grunewald, Elisabeth Schneider, Gundula Haunschild, Nina Patwary, Severin Guetter, Sandra Huber, Brigitte Rack, Nadia Harbeck, Stefan Buchholz, Petra Rümmele, Norbert Heine, Stefan Rose-John, Christoph A. Klein
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Metastatic dissemination in breast cancer patients occurs early in malignant transformation, raising questions about how disseminated cancer cells (DCC) progress at distant sites. Here, the authors show that DCCs in bone marrow are activated via IL6-
Externí odkaz:
https://doaj.org/article/852fb79d2cfa456b923be4f3ce115b15
Autor:
Melanie S. Patzak, Vijayalakshmi Kari, Shilpa Patil, Feda H. Hamdan, Robert G. Goetze, Marius Brunner, Jochen Gaedcke, Julia Kitz, Duncan I. Jodrell, Frances M. Richards, Christian Pilarsky, Robert Gruetzmann, Petra Rümmele, Thomas Knösel, Elisabeth Hessmann, Volker Ellenrieder, Steven A. Johnsen, Albrecht Neesse
Publikováno v:
EBioMedicine, Vol 40, Iss , Pp 394-405 (2019)
Background: Cytosolic 5′-nucleotidase 1A (NT5C1A) dephosphorylates non-cyclic nucleoside monophosphates to produce nucleosides and inorganic phosphates. Here, we investigate NT5C1A expression in pancreatic ductal adenocarcinoma (PDAC) and its impac
Externí odkaz:
https://doaj.org/article/195147ef850549bba1a4da0c7a0248e9
Autor:
Melanie Werner-Klein, Sebastian Scheitler, Martin Hoffmann, Isabelle Hodak, Klaus Dietz, Petra Lehnert, Veronika Naimer, Bernhard Polzer, Steffi Treitschke, Christian Werno, Aleksandra Markiewicz, Kathrin Weidele, Zbigniew Czyz, Ulrich Hohenleutner, Christian Hafner, Sebastian Haferkamp, Mark Berneburg, Petra Rümmele, Anja Ulmer, Christoph A. Klein
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
For several cancer types, mouse models indicate that metastasis occurs early. Here, the authors show that human melanoma cells disseminate early and illustrate a genetic colonisation signature that evolves in parallel at different sites.
Externí odkaz:
https://doaj.org/article/08484ba36c924d67bd84ae818b551c58
Autor:
Felix Elsner, Martin Hoffmann, Rezan Fahrioglu‐Yamaci, Zbigniew Czyz, Giancarlo Feliciello, Tobias Mederer, Bernhard Polzer, Steffi Treitschke, Petra Rümmele, Florian Weber, Hellmuth Wiesinger, Tobias Robold, Zsolt Sziklavari, Wulf Sienel, Hans‐Stefan Hofmann, Christoph A Klein
Publikováno v:
The Journal of Pathology. 258:250-263
In melanoma, immunocytology (IC) after sentinel lymph node disaggregation not only enables better quantification of disseminated cancer cells (DCCs) than routine histopathology (HP) but also provides a unique opportunity to detect, isolate, and analy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92f1b7205c45db6a2eac2bba2e445508
https://doi.org/10.1002/path.5996
https://doi.org/10.1002/path.5996
Autor:
Maria E. Mycielska, Markus T. J. Mohr, Katharina Schmidt, Konstantin Drexler, Petra Rümmele, Sebastian Haferkamp, Hans J. Schlitt, Andreas Gaumann, Jerzy Adamski, Edward K. Geissler
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
We have recently discovered that cancer cells take up extracellular citrate through plasma membrane citrate transporter (pmCiC) and advantageously use citrate for their metabolism. Citrate uptake can be blocked with gluconate and this results in decr
Externí odkaz:
https://doaj.org/article/94167722af1242ae8c4c8509999316e3
Autor:
Edward K. Geissler, Peter J. Oefner, Jerzy Adamski, Sven A. Lang, Andreas Gaumann, Christian H. Wetzel, Christine Ziegler, Karl Kunzelmann, Hans J. Schlitt, Vadivel Ganapathy, Christian J. Wachsmuth, Elke Eggenhofer, Gudrun E. Koehl, Alexander Cecil, Moritz Schladt, Margareta Lantow, Gregor M. Madej, Wolfgang Jagla, Vladimir M. Milenkovic, Cornelia Prehn, Katharina Schmidt, Petra Rümmele, Katja Dettmer, Maria E. Mycielska
Krebs cycle activity in the presence of extracellular citrate and absolute citrate levels.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33562ad332dd0da3e0d23cbf15bbe656
https://doi.org/10.1158/0008-5472.22419494.v1
https://doi.org/10.1158/0008-5472.22419494.v1
Autor:
Edward K. Geissler, Peter J. Oefner, Jerzy Adamski, Sven A. Lang, Andreas Gaumann, Christian H. Wetzel, Christine Ziegler, Karl Kunzelmann, Hans J. Schlitt, Vadivel Ganapathy, Christian J. Wachsmuth, Elke Eggenhofer, Gudrun E. Koehl, Alexander Cecil, Moritz Schladt, Margareta Lantow, Gregor M. Madej, Wolfgang Jagla, Vladimir M. Milenkovic, Cornelia Prehn, Katharina Schmidt, Petra Rümmele, Katja Dettmer, Maria E. Mycielska
List of metabolites measured with the AbsoluteIDQ® p180 Kit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::408231ff14334a296c84657258cda4df
https://doi.org/10.1158/0008-5472.22419476
https://doi.org/10.1158/0008-5472.22419476
Autor:
Edward K. Geissler, Peter J. Oefner, Jerzy Adamski, Sven A. Lang, Andreas Gaumann, Christian H. Wetzel, Christine Ziegler, Karl Kunzelmann, Hans J. Schlitt, Vadivel Ganapathy, Christian J. Wachsmuth, Elke Eggenhofer, Gudrun E. Koehl, Alexander Cecil, Moritz Schladt, Margareta Lantow, Gregor M. Madej, Wolfgang Jagla, Vladimir M. Milenkovic, Cornelia Prehn, Katharina Schmidt, Petra Rümmele, Katja Dettmer, Maria E. Mycielska
Intracellular Ca2+ in the presence of extracellular citrate.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a535b0300734e156283b03f831ae8bd8
https://doi.org/10.1158/0008-5472.22419497.v1
https://doi.org/10.1158/0008-5472.22419497.v1
Autor:
Edward K. Geissler, Peter J. Oefner, Jerzy Adamski, Sven A. Lang, Andreas Gaumann, Christian H. Wetzel, Christine Ziegler, Karl Kunzelmann, Hans J. Schlitt, Vadivel Ganapathy, Christian J. Wachsmuth, Elke Eggenhofer, Gudrun E. Koehl, Alexander Cecil, Moritz Schladt, Margareta Lantow, Gregor M. Madej, Wolfgang Jagla, Vladimir M. Milenkovic, Cornelia Prehn, Katharina Schmidt, Petra Rümmele, Katja Dettmer, Maria E. Mycielska
Glycolysis and fatty acid synthesis are highly active in cancer cells through cytosolic citrate metabolism, with intracellular citrate primarily derived from either glucose or glutamine via the tricarboxylic acid cycle. We show here that extracellula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::55b93db68abae791c8ca94d3e47f4aed
https://doi.org/10.1158/0008-5472.c.6510392.v1
https://doi.org/10.1158/0008-5472.c.6510392.v1
Autor:
Elisabeth Jahny, Hai Yang, Bin Liu, Beatrix Jahnke, Franziska Lademann, Thomas Knösel, Petra Rümmele, Robert Grützmann, Daniela E Aust, Christian Pilarsky, Axel Denz
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0170390 (2017)
Pancreatic Ductal Adenocarcinoma (PDAC) is one of the deadliest tumors worldwide. Understanding the function of gene expression alterations is a prerequisite for developing new strategies in diagnostic and therapy. GPRC5A (RAI3), coding for a seven t
Externí odkaz:
https://doaj.org/article/2a38954f87e44e79aa01c41780858705