NS5A inhibitors unmask differences in functional replicase complex half-life between different hepatitis C virus strains.

Autor: Tiffany Benzine, Ryan Brandt, William C Lovell, Daisuke Yamane, Petra Neddermann, Raffaele De Francesco, Stanley M Lemon, Alan S Perelson, Ruian Ke, David R McGivern

Publikováno v: PLoS Pathogens, Vol 13, Iss 6, p e1006343 (2017)

Hepatitis C virus (HCV) RNA is synthesized by the replicase complex (RC), a macromolecular assembly composed of viral non-structural proteins and cellular co-factors. Inhibitors of the HCV NS5A protein block formation of new RCs but do not affect RNA

Externí odkaz: https://doaj.org/article/7b1cb227313a48df89ea03f08b8da13e

Metabolism of phosphatidylinositol 4-kinase IIIα-dependent PI4P Is subverted by HCV and is targeted by a 4-anilino quinazoline with antiviral activity.

Autor: Annalisa Bianco, Veronica Reghellin, Lorena Donnici, Simone Fenu, Reinaldo Alvarez, Chiara Baruffa, Francesco Peri, Massimiliano Pagani, Sergio Abrignani, Petra Neddermann, Raffaele De Francesco

Publikováno v: PLoS Pathogens, Vol 8, Iss 3, p e1002576 (2012)

4-anilino quinazolines have been identified as inhibitors of HCV replication. The target of this class of compounds was proposed to be the viral protein NS5A, although unequivocal proof has never been presented. A 4-anilino quinazoline moiety is ofte

Externí odkaz: https://doaj.org/article/0c7408dee75a4019a571d0424fdeb602

Contributors

Autor: Sergio Abrignani, S. Sohail Ahmed, Ian J. Amanna, Teresa A. Anderson, Peter R. Arlett, William L. Atkinson, Francisco M. Averhoff, R. Bruce Aylward, Martin F. Bachmann, Carol J. Baker, Henry H. Balfour, W. Ripley Ballou, Ralph S. Baric, Alan D.T. Barrett, Elizabeth D. Barnett, Lahouari Belgharbi, Elliot M. Berinstein, Neil L. Berinstein, Jeffrey M. Bethony, Hugues Bogaerts, Adrian Bot, Philip S. Brachman, Joseph S. Bresee, Alireza Khadem Broojerdi, Arthur L. Caplan, Marco Cavaleri, Thomas Cherian, Pele Choi-Sing, John D. Clemens, Stephen L. Cochi, Amanda Cohn, Capt. Margaret M. Cortese, Nancy J. Cox, Felicity Cutts, Ron Dagan, Harry R. Dalton, Robert S. Daum, Andrea Sudell Davey, Raffaele De Francesco, Kari Debbink, Michael D. Decker, Sachin N. Desai, Frank DeStefano, R. Gordon Douglas, Katrin Dubischar, W. John Edmunds, Kathryn M. Edwards, William Egan, Rudolf Eggers, Falk Ehmann, Ronald W. Ellis, Aadil El-Turabi, Dean D. Erdman, Hildegund Ertl, Paul E.M. Fine, Theresa M. Finn, Allison Fisher, Martin Friede, Arthur M. Friedlander, Alicia M. Fry, Nathalie Garçon, Paul A. Gastañaduy, Mark D. Gershman, Anne A. Gershon, Bradford D. Gessner, Peter Gilbert, Ann M. Ginsberg, Marc P. Girard, Phillip L. Gomez, James L. Goodson, Robert R. Goodwin, Lance K. Gordon, John D. Grabenstein, Barney S. Graham, Rachel L. Graham, Dan M. Granoff, Gregory C. Gray, Marion F. Gruber, Scott B. Halstead, Willem Hanekom, Lee H. Harrison, Thomas R. Hawn, C. Mary Healy, Donald A. Henderson, Allan Hildesheim, Susan L. Hills, Jan Holmgren, Joachim Hombach, Peter J. Hotez, Michael Houghton, Avril Melissa Houston, Barbara J. Howe, Jacques Izopet, Denise J. Jamieson, Courtney Jarrahian, Kari Johansen, Ruth A. Karron, Richard B. Kennedy, Olen M. Kew, Yury Khudyakov, Michel Klein, Keith P. Klugman, Jacob F. Kocher, Wayne C. Koff, Herwig Kollaritsch, Karen L. Kotloff, Phyllis E. Kozarsky, Andrew T. Kroger, Xavier Kurz, Seema S. Lakdawala, J. Michael Lane, Kendra Leigh, Myron J. Levin, Emily Marcus Levine, Myron M. Levine, Lisa C. Lindesmith, Per Ljungman, Douglas R. Lowy, Catherine J. Luke, Anna Lundgren, Patrick Lydon, Richard Malley, Mona Marin, Lauri E. Markowitz, Lieut. Valerie B. Marshall, Mark A. Miller, Thomas P. Monath, William J. Moss, Kim Mulholland, Daniel M. Musher, Gary J. Nabel, Thirumeni Nagarajan, GB Nair, Srinivas Acharya Nanduri, Petra Neddermann, Noele P. Nelson, Paul A. Offit, Jean-Marie Okwo-Bele, Saad B. Omer, Walter A. Orenstein, Petra C.F. Oyston, Mark J. Papania, Umesh D. Parashar, Dina Pfeifer, Larry K. Pickering, Phillip R. Pittman, Aurélie Ploquin, Stanley A. Plotkin, Susan L. Plotkin, Gregory A. Poland, Andrew J. Pollard, Firdausi Qadri, Mary R. Quirk, Raman D.S.V. Rao, Rino Rappuoli, Susan E. Reef, Alison D. Ridpath, James M. Robinson, Lance E. Rodewald, Carmen A. Rodriguez-Hernandez, Martha H. Roper, Steven A. Rubin, Charles E. Rupprecht, William A. Rutala, David Salisbury, Vijay B. Samant, Suryaprakash Sambhara, Mathuram Santosham, John T. Schiller, Mark R. Schleiss, Anne Schuchat, Jason L. Schwartz, Heather M. Scobie, J. Anthony Scott, Jane F. Seward, Daniel Shouval, Claire-Anne Siegrist, Mark K. Slifka, Samir V. Sodha, Lawrence R. Stanberry, J. Erin Staples, Allen C. Steere, Robert Steffen, Peter M. Strebel, Kanta Subbarao, Nancy J. Sullivan, Catherine G. Sutcliffe, Andrea R. Sutherland, Roland W. Sutter, Stephen J. Thomas, Tejpratap S.P Tiwari, Theodore F. Tsai, Pierre Van Damme, Johan Vekemans, Emmanuel Vidor, John W. Ward, Steven G.F. Wassilak, David J. Weber, David B. Weiner, Deborah L. Wexler, Melinda Wharton, Cynthia G. Whitney, E. Diane Williamson, David J. Wood, Ningshao Xia, Zhi Yi Xu, Alessandro Zanetti, Darin Zehrung

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7acf81f8a449a2d66f4a232ecf59e927
https://doi.org/10.1016/b978-0-323-35761-6.00092-4

Erratum: Tuning a cellular lipid kinase activity adapts hepatitis C virus to replication in cell culture

Autor: Christian Harak, Max Meyrath, Inés Romero-Brey, Christian Schenk, Claire Gondeau, Philipp Schult, Katharina Esser-Nobis, Mohsan Saeed, Petra Neddermann, Paul Schnitzler, Daniel Gotthardt, Sofia Perez-del-Pulgar, Christoph Neumann-Haefelin, Robert Thimme, Philip Meuleman, W. R. Vondran Florian, Raffaele De Francesco, Charles M. Rice, Ralf Bartenschlager, Volker Lohmann

Publikováno v: Nature Microbiology
Nature Microbiology, Nature Publishing Group, 2017, 2 (3), ⟨10.1038/nmicrobiol.2017.12⟩

International audience

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bac8ae70dcc45a47646e1d1195e926e
https://pubmed.ncbi.nlm.nih.gov/27991882

Tuning a cellular lipid kinase activity adapts hepatitis C virus to replication in cell culture

Autor: Daniel Gotthardt, Paul Schnitzler, Max Meyrath, Petra Neddermann, Ralf Bartenschlager, Inés Romero-Brey, Katharina Esser-Nobis, Philip Meuleman, Robert Thimme, Charles M. Rice, Christian Schenk, Florian W. R. Vondran, Claire Gondeau, Christian Harak, Mohsan Saeed, Raffaele De Francesco, Philipp Schult, Volker Lohmann, Sofía Pérez-del-Pulgar, Christoph Neumann-Haefelin

Publikováno v: Nature Microbiology
Nature Microbiology, Nature Publishing Group, 2016, 2, pp.16247. ⟨10.1038/nmicrobiol.2016.247⟩

With a single exception, all isolates of hepatitis C virus (HCV) require adaptive mutations to replicate efficiently in cell culture. Here, we show that a major class of adaptive mutations regulates the activity of a cellular lipid kinase, phosphatid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09ab27804d193435af457db0fb915dde
https://pubmed.ncbi.nlm.nih.gov/28112725