Zobrazeno 1 - 10
of 186
pro vyhledávání: '"Petra, Kleinbongard"'
Autor:
Merry L. Lindsey, Keith R. Brunt, Petra Kleinbongard, Jason R. Carter, Crystal M. Ripplinger, Zamaneh Kassiri, Kara Hansell Keehan, Amanda J. LeBlanc, Jonathan A. Kirk
Publikováno v:
Physiological Reports, Vol 12, Iss 5, Pp n/a-n/a (2024)
Externí odkaz:
https://doaj.org/article/a7f373ce99b647f0b7a1df3c43d92000
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 8, p 4491 (2024)
Myocardial ischemia/reperfusion injury is reduced by cardioprotective adaptations such as local or remote ischemic conditioning. The cardioprotective stimuli activate signaling cascades, which converge on mitochondria and maintain the function of the
Externí odkaz:
https://doaj.org/article/fd8551e479d24b469684009f220b5d65
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
IntroductionDiazoxide is a powerful cardioprotective agent that activates mitochondrial ATP-dependent K-channels and stimulates mitochondrial respiration. Diazoxide reduced infarct size in isolated rodent heart preparations and upon pretreatment in j
Externí odkaz:
https://doaj.org/article/b2d4538d47d74f1099b721abc96e8c86
Autor:
Helmut Raphael Lieder MD, Pia Tüller, Felix Braczko MSc, Afsaneh Zandi MD, Markus Kamler MD, Matthias Thielmann MD, Gerd Heusch MD, Petra Kleinbongard MD, PhD
Publikováno v:
Journal of Cardiovascular Pharmacology and Therapeutics, Vol 27 (2022)
Remote ischemic conditioning (RIC) induces the release of circulating cardioprotective factors and attenuates myocardial ischemia/reperfusion injury. Evidence for such humoral cardioprotective factor(s) is derived from transfer with plasma (derivativ
Externí odkaz:
https://doaj.org/article/f54c72111136459da2fbe78eeed8ade0
Autor:
Janina Pape, Helena Kerp, Helmut R. Lieder, Daniela Geist, Georg Sebastian Hönes, Lars C. Moeller, Petra Kleinbongard, Dagmar Führer
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 21, p 13340 (2022)
Hypothyroidism has been shown to reduce infarct size in rats, but the underlying mechanisms are unclear. We used isolated pressure-constant perfused hearts of control, hypothyroid and hyperthyroid mice and measured infarct size, functional parameters
Externí odkaz:
https://doaj.org/article/a8777e918488495f92af54c657a6ade4
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 323:H1365-H1375
Ischemic preconditioning (IPC; brief cycles of coronary occlusion/reperfusion) is operative in all species tested so far and reduces infarct size through the release of trigger molecules and activation of signal transducer and activator of transcript
Autor:
Frederik Abel, Florian Murke, Morten Gaida, Nicolas Garnier, Crista Ochsenfarth, Carsten Theiss, Matthias Thielmann, Petra Kleinbongard, Bernd Giebel, Jürgen Peters, Ulrich H Frey
Publikováno v:
PLoS ONE, Vol 15, Iss 2, p e0228948 (2020)
Remote ischemic preconditioning (RIPC) can evoke cardioprotection following ischemia/reperfusion and this may depend on the anesthetic used. We tested whether 1) extracellular vesicles (EVs) isolated from humans undergoing RIPC protect cardiomyoblast
Externí odkaz:
https://doaj.org/article/2bd45418e67a412589a8e4d74a03cba9
Autor:
Petra, Kleinbongard, Philipp, Kuthan, Chantal, Eickelmann, Philipp, Jakobs, Joachim, Altschmied, Judith, Haendeler, Arjang, Ruhparwar, Matthias, Thielmann, Gerd, Heusch
Publikováno v:
International Journal of Cardiology. 363:159-162
In patients undergoing interventional or surgical coronary revascularization, subclinical hypothyroidism is common and associated with worse outcome, including the need for postoperative inotropic support. In isolated rat hearts with global ischemia/
Autor:
Chantal Eickelmann, Helmut Raphael Lieder, Sharaf-Eldin Shehada, Matthias Thielmann, Gerd Heusch, Petra Kleinbongard
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology.
Mitochondrial function is critical to myocardial ischemia/reperfusion injury and cardioprotection. The measurement of mitochondrial function in isolated mitochondria requires cardiac specimens of about 300 mg and is therefore only possible at the end
Publikováno v:
Physiology. 38
Background: Vagal activation during remote ischemic conditioning (RIC) with subsequent release of cardioprotective factors from the spleen into the circulation reduces infarct size. These humoral cardioprotective factors can be transferred with plasm