Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Petr Simecek"'
Publikováno v:
Frontiers in Genetics, Vol 11 (2020)
G-quadruplexes (G4s) are a class of stable structural nucleic acid secondary structures that are known to play a role in a wide spectrum of genomic functions, such as DNA replication and transcription. The classical understanding of G4 structure poin
Externí odkaz:
https://doaj.org/article/ef7e0e50e54f4b6ca151eb0f8f6070e4
Autor:
Petr Simecek, Jiri Forejt, Robert W. Williams, Toshihiko Shiroishi, Toyoyuki Takada, Lu Lu, Thomas E. Johnson, Beth Bennett, Christian F. Deschepper, Marie-Pier Scott-Boyer, Fernando Pardo-Manuel de Villena, Gary A. Churchill
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 7, Iss 10, Pp 3427-3434 (2017)
Genetic reference panels are widely used to map complex, quantitative traits in model organisms. We have generated new high-resolution genetic maps of 259 mouse inbred strains from recombinant inbred strain panels (C57BL/6J × DBA/2J, ILS/IbgTejJ ×
Externí odkaz:
https://doaj.org/article/56ad0f6161d44b23a404ecacde21b422
Autor:
John P Didion, Andrew P Morgan, Amelia M-F Clayshulte, Rachel C Mcmullan, Liran Yadgary, Petko M Petkov, Timothy A Bell, Daniel M Gatti, James J Crowley, Kunjie Hua, David L Aylor, Ling Bai, Mark Calaway, Elissa J Chesler, John E French, Thomas R Geiger, Terry J Gooch, Theodore Garland, Alison H Harrill, Kent Hunter, Leonard McMillan, Matt Holt, Darla R Miller, Deborah A O'Brien, Kenneth Paigen, Wenqi Pan, Lucy B Rowe, Ginger D Shaw, Petr Simecek, Patrick F Sullivan, Karen L Svenson, George M Weinstock, David W Threadgill, Daniel Pomp, Gary A Churchill, Fernando Pardo-Manuel de Villena
Publikováno v:
PLoS Genetics, Vol 11, Iss 2, p e1004850 (2015)
Significant departures from expected Mendelian inheritance ratios (transmission ratio distortion, TRD) are frequently observed in both experimental crosses and natural populations. TRD on mouse Chromosome (Chr) 2 has been reported in multiple experim
Externí odkaz:
https://doaj.org/article/53c2f98bb98349e2a1907e6090291e44
Autor:
Tanmoy Bhattacharyya, Radka Reifova, Sona Gregorova, Petr Simecek, Vaclav Gergelits, Martin Mistrik, Iva Martincova, Jaroslav Pialek, Jiri Forejt
Publikováno v:
PLoS Genetics, Vol 10, Iss 2, p e1004088 (2014)
Hybrid sterility (HS) belongs to reproductive isolation barriers that safeguard the integrity of species in statu nascendi. Although hybrid sterility occurs almost universally among animal and plant species, most of our current knowledge comes from t
Externí odkaz:
https://doaj.org/article/1de0dd3f8c594ae0b7e0233146529df4
Publikováno v:
bioRxiv
Background Recently, deep neural networks have been successfully applied in many biological fields. In 2020, a deep learning model AlphaFold won the protein folding competition with predicted structures within the error tolerance of experimental meth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e91ea7941c6f1cd287b2f425468d1c5f
https://doi.org/10.1186/s12863-023-01123-8
https://doi.org/10.1186/s12863-023-01123-8
Transformers are a type of neural network architecture that has been successfully used to achieve state-of-the-art performance in numerous natural language processing tasks. However, what about DNA, the language life written in the four-letter alphab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ea8907e2507891b1dbbeee64ded7985
https://doi.org/10.1101/2022.02.07.479412
https://doi.org/10.1101/2022.02.07.479412
Autor:
Joel M. Chick, Steven C. Munger, Petr Simecek, Edward L. Huttlin, Kwangbom Choi, Daniel M. Gatti, Narayanan Raghupathy, Karen L. Svenson, Gary A. Churchill, Steven P. Gygi
Publikováno v:
Nature. 606:E16-E16
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d25d23d107f6dd4d072ea92909dd7364
https://doi.org/10.1038/s41586-022-04920-w
https://doi.org/10.1038/s41586-022-04920-w
Publikováno v:
Genetics
During meiosis, the recombination-initiating DNA double-strand breaks (DSBs) are repaired by crossovers or noncrossovers (gene conversions). While crossovers are easily detectable, noncrossover identification is hampered by the small size of their co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbe6f88d0180ab975fa435f8f35b64cb
https://europepmc.org/articles/PMC8045703/
https://europepmc.org/articles/PMC8045703/
Autor:
Daniel M. Gatti, Brendan T. Keenan, Diane C. Lim, Petr Simecek, Karen L. Svenson, Jie Lian, Allan I. Pack, Lin Zhang, Raymond J. Galante, Gary A. Churchill
Publikováno v:
Sleep
Study ObjectivesThis study describes high-throughput phenotyping strategies for sleep and circadian behavior in mice, including examinations of robustness, reliability, and heritability among Diversity Outbred (DO) mice and their eight founder strain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14785c9f5d24b7433dd1ab8ba24bc9d8
https://europepmc.org/articles/PMC7215270/
https://europepmc.org/articles/PMC7215270/
Autor:
Brian S. Yandell, Matthew Vincent, Christina Kendziorski, Mary E. Rabaglia, Kathryn L. Schueler, Rhonda Bacher, Petr Simecek, Donnie S. Stapleton, Mark P. Keller, Sadie Allen, Aimee Teo Broman, Karl W. Broman, Daniel M. Gatti, Gary A. Churchill, Alan D. Attie
Publikováno v:
Genetics. 209:335-356
The majority of gene loci that have been associated with type 2 diabetes play a role in pancreatic islet function. To evaluate the role of islet gene expression in the etiology of diabetes, we sensitized a genetically diverse mouse population with a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e37c19b58c7e6bec308f863ff4bdb304
https://doi.org/10.1534/genetics.118.300864
https://doi.org/10.1534/genetics.118.300864