Zobrazeno 1 - 10
of 161
pro vyhledávání: '"Petr Pavek"'
Autor:
Anna Durinova, Lucie Smutna, Pavel Barta, Rajamanikkam Kamaraj, Tomas Smutny, Bernhard Schmierer, Petr Pavek, Frantisek Trejtnar
Publikováno v:
EJNMMI Radiopharmacy and Chemistry, Vol 9, Iss 1, Pp 1-16 (2024)
Abstract Background Megalin (LRP2 receptor) mediates the endocytosis of radiolabeled peptides into proximal tubular kidney cells, which may cause nephrotoxicity due to the accumulation of a radioactive tracer. The study aimed to develop a cellular mo
Externí odkaz:
https://doaj.org/article/597d143506c24767ad940c67ab4c86df
Autor:
Fatemeh Alaei Faradonbeh, Hana Lastuvkova, Jolana Cermanova, Milos Hroch, Zuzana Nova, Martin Uher, Petra Hirsova, Petr Pavek, Stanislav Micuda
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Multidrug resistance-associated protein 2 (Mrp2) mediates biliary secretion of anionic endobiotics and xenobiotics. Genetic alteration of Mrp2 leads to conjugated hyperbilirubinemia and predisposes to the development of intrahepatic cholestasis of pr
Externí odkaz:
https://doaj.org/article/3d846cddeca1478a836441a3e6a261b4
Autor:
Tomas Smutny, Jan Dusek, Lucie Hyrsova, Jana Nekvindova, Alzbeta Horvatova, Stanislav Micuda, Sabine Gerbal-Chaloin, Petr Pavek
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 10, Iss 1, Pp 136-152 (2020)
Pregnane X receptor (PXR) is the major regulator of xenobiotic metabolism. PXR itself is controlled by various signaling molecules including glucocorticoids. Moreover, negative feed-back regulation has been proposed at the transcriptional level. We e
Externí odkaz:
https://doaj.org/article/104e530f438645bb88ef9570631024be
Autor:
Alzbeta Stefela, Miroslav Kaspar, Martin Drastik, Thales Kronenberger, Stanislav Micuda, Martin Dracinsky, Blanka Klepetarova, Eva Kudova, Petr Pavek
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Bile acids (BAs) are key signaling steroidal molecules that regulate glucose, lipid, and energy homeostasis via interactions with the farnesoid X receptor (FXR) and G-protein bile acid receptor 1 (GPBAR1). Extensive medicinal chemistry modifications
Externí odkaz:
https://doaj.org/article/41d6b0e2df9d4724951d8ee7df1dc6a6
Publikováno v:
Cells, Vol 11, Iss 19, p 2974 (2022)
The pregnane X receptor (PXR, NR1I2) is a xenobiotic-activated transcription factor with high levels of expression in the liver. It not only plays a key role in drug metabolism and elimination, but also promotes tumor growth, drug resistance, and met
Externí odkaz:
https://doaj.org/article/de607d68ad2e43dbb50e089162525b94
Autor:
Hana Lastuvkova, Fatemeh Alaei Faradonbeh, Jolana Schreiberova, Milos Hroch, Jaroslav Mokry, Hana Faistova, Zuzana Nova, Radomír Hyspler, Ivone Cristina Igreja Sa, Petr Nachtigal, Alzbeta Stefela, Petr Pavek, Stanislav Micuda
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 12, p 6468 (2021)
Bile acids (BA) play a significant role in the pathophysiology of nonalcoholic steatohepatitis (NASH). The present study evaluates the modulation of bile acid metabolomics by atorvastatin, a cholesterol-lowering agent commonly used to treat cardiovas
Externí odkaz:
https://doaj.org/article/47f7ff62a5294ce8bc65ce122e724e47
Autor:
Barbora Boltnarova, Jana Kubackova, Josef Skoda, Alzbeta Stefela, Monika Smekalova, Petra Svacinova, Ivona Pavkova, Milan Dittrich, Daniel Scherman, Jarmila Zbytovska, Petr Pavek, Ondrej Holas
Publikováno v:
Nanomaterials, Vol 11, Iss 3, p 749 (2021)
Macrophages possess an innate ability to scavenge heterogenous objects from the systemic circulation and to regulate inflammatory diseases in various organs via cytokine production. That makes them attractive targets for nanomedicine-based therapeuti
Externí odkaz:
https://doaj.org/article/035f8cab806046ac9246a965110ad88a
Autor:
Jana Kubackova, Ondrej Holas, Jarmila Zbytovska, Barbora Vranikova, Guanghong Zeng, Petr Pavek, Anette Mullertz
Publikováno v:
Pharmaceutics, Vol 13, Iss 4, p 459 (2021)
Oligonucleotides (OND) represent a promising therapeutic approach. However, their instability and low intestinal permeability hamper oral bioavailability. Well-established for oral delivery, self-emulsifying drug delivery systems (SEDDS) can overcome
Externí odkaz:
https://doaj.org/article/3583787294824494b2dabf346e4b1887
Autor:
Josef Skoda, Jan Dusek, Martin Drastik, Alzbeta Stefela, Klara Dohnalova, Karel Chalupsky, Tomas Smutny, Stanislav Micuda, Sabine Gerbal-Chaloin, Petr Pavek
Publikováno v:
Cells, Vol 9, Iss 12, p 2532 (2020)
The constitutive androstane receptor (CAR) is the essential regulator of genes involved both in xenobiotic and endobiotic metabolism. Diazepam has been shown as a potent stimulator of CAR nuclear translocation and is assumed as an indirect CAR activa
Externí odkaz:
https://doaj.org/article/7c2b6c2d073147058fe91e7104860ab2
Autor:
Petr Pavek
Publikováno v:
Frontiers in Pharmacology, Vol 7 (2016)
Pregnane X receptor is a ligand-activated nuclear receptor that mainly controls inducible expression of xenobiotics handling genes including biotransformation enzymes and drug transporters. Nowadays it is clear that PXR is also involved in regulation
Externí odkaz:
https://doaj.org/article/9c894bdb36cf43d895be5e14c2215065