Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Petr Pachl"'
Autor:
Jana Pokorná, Petr Pachl, Elena Karlukova, Jakub Hejdánek, Pavlína Řezáčová, Aleš Machara, Jason Hudlický, Jan Konvalinka, Milan Kožíšek
Publikováno v:
Viruses, Vol 10, Iss 7, p 339 (2018)
Neuraminidase is the main target for current influenza drugs. Reduced susceptibility to oseltamivir, the most widely prescribed neuraminidase inhibitor, has been repeatedly reported. The resistance substitutions I223V and S247N, alone or in combinati
Externí odkaz:
https://doaj.org/article/44eddd899f814570bf7ec6d9a06db19a
Autor:
Jan Skácel, Stefan Djukic, Ondřej Baszczyňski, Filip Kalčic, Tadeáš Bílek, Karel Chalupský, Jaroslav Kozák, Alexandra Dvořáková, Eva Tloušt’ová, Zuzana Král’ová, Markéta Šmídková, Jan Voldřich, Michaela Rumlová, Petr Pachl, Jiří Brynda, Tereza Vučková, Milan Fábry, Jan Snášel, Iva Pichová, Pavlína Řezáčová, Helena Mertlíková-Kaiserová, Zlatko Janeba
Publikováno v:
Journal of Medicinal Chemistry. 66:6652-6681
Autor:
Jason K K Low, Karishma Patel, Paul Solomon, Alexander Norman, Petr Pachl, Natasha Jones, Richard J Payne, Toby Passioura, Hiroaki Suga, Louise J Walport, Joel P Mackay
Bromodomains regulate gene expression by recognizing protein motifs containing acetyllysine. Although originally characterized as histone-binding proteins, it has since become clear that these domains interact with other acetylated proteins, perhaps
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27ab2199ddb8297634faec9650223e54
https://doi.org/10.1101/2023.05.17.541126
https://doi.org/10.1101/2023.05.17.541126
Autor:
Michal Buša, Zuzana Matoušková, Pavla Bartošová-Sojková, Petr Pachl, Pavlína Řezáčová, Ramon Marc Eichenberger, Peter Deplazes, Martin Horn, Saša Štefanić, Michael Mareš
Publikováno v:
Journal of Biological Chemistry. 299:102970
Autor:
Pavla Fajtová, Jim Küppers, Jindřich Fanfrlík, Michael Mareš, Marta Chanová, Petr Pachl, Adéla Jílková, Conor R. Caffrey, Martin Lepšík, Pavlína Řezáčová, Michael Gütschow, Martin Horn, Petra Rubešová
Publikováno v:
ACS Infectious Diseases
Azapeptide nitriles are postulated to reversibly covalently react with the active-site cysteine residue of cysteine proteases and form isothiosemicarbazide adducts. We investigated the interaction of azadipeptide nitriles with the cathepsin B1 drug t
Publikováno v:
Journal of Biological Chemistry. 299:103674
Autor:
Lyudmila A. Emelianova, Grzegorz Chojnowski, Petr Pachl, Nina V. Tikunova, Ivan K. Baykov, N. A. Moor, Pavlina Rezacova, Victor S. Lamzin, Andrey L. Matveev
Tick-borne encephalitis virus (TBEV) causes about 5-6 thousand cases annually, while there is still no effective treatment for this virus. To fill this gap, a high-affinity chimeric anti-TBEV antibody ch14D5 has previously been constructed, and high
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dedb265bcc11ce2e4dcdddbe61326da6
https://doi.org/10.1101/2021.07.28.453943
https://doi.org/10.1101/2021.07.28.453943
Autor:
Zlatko Janeba, Alena Zíková, Martina Slapničková, Lenka Poštová Slavětínská, Petr Pachl, Jan Frydrych, Filip Kalčic, Martin Dračínský, Dana Hocková, Eva Doleželová
Publikováno v:
European journal of medicinal chemistry. 225
Some pathogens, including parasites of the genus Trypanosoma causing Human and Animal African Trypanosomiases, cannot synthesize purines de novo and they entirely rely on the purine salvage pathway (PSP) for their nucleotide generation. Thus, their P
Autor:
Soňa Gurská, Bohumír Grüner, Jana Štěpánková, Marian Hajduch, K. Pospisilova, Alice Nova, Pavlína Řezáčová, Václav Šícha, Milan Fábry, Vlastimil Mašek, Petr Džubák, Stanislava Matějková, Jan Nekvinda, Petr Pachl, Josef Holub, Viswanath Das, Jiří Brynda, Barbora Lišková, Martina Medvedíková, Vlastimil Král, M. Kugler
Publikováno v:
Journal of Medicinal Chemistry. 62:9560-9575
Carbonic anhydrase IX (CAIX) is a transmembrane enzyme that regulates pH in hypoxic tumors and promotes tumor cell survival. Its expression is associated with the occurrence of metastases and poor prognosis. Here, we present nine derivatives of the c
Autor:
Ivana Kuta Smatanova, Tatyana Prudnikova, Petr Pachl, Jiri Brynda, Pavlina Rezacova, Joseph D. Ng, Marc L. Pusey, Barbora Kascakova, Petra Havlickova, Vitezslav Brinsa, Jeroen R. Mesters, Michal Kuty
Publikováno v:
Acta Crystallographica Section D Structural Biology. 75:743-752
The haloacid dehalogenase (HAD) superfamily is one of the largest known groups of enzymes and the majority of its members catalyze the hydrolysis of phosphoric acid monoesters into a phosphate ion and an alcohol. Despite the fact that sequence simila