Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Petr Maly"'
Publikováno v:
Journal of Biomedical Science, Vol 31, Iss 1, Pp 1-16 (2024)
Abstract Human immunodeficiency virus type 1 (HIV-1) vaccine immunogens capable of inducing broadly neutralizing antibodies (bNAbs) remain obscure. HIV-1 evades immune responses through enormous diversity and hides its conserved vulnerable epitopes o
Externí odkaz:
https://doaj.org/article/188eec09a91b4c02873a0e0284bafd18
Autor:
Leona Raskova Kafkova, Joanna M. Mierzwicka, Prosenjit Chakraborty, Petr Jakubec, Ondrej Fischer, Jozef Skarda, Petr Maly, Milan Raska
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Non-small cell lung cancer (NSCLC) is largely promoted by a multistep tumorigenesis process involving various genetic and epigenetic alterations, which essentially contribute to the high incidence of mortality among patients with NSCLC. Clinical obse
Externí odkaz:
https://doaj.org/article/9ea9c310c79145f588c8e0fcd68b2a5b
Autor:
Petr Kosztyu, Milan Kuchar, Jiri Cerny, Lucia Barkocziova, Michal Maly, Hana Petrokova, Lydie Czernekova, Veronika Liskova, Leona Raskova Kafkova, Pavlina Knotigova, Josef Masek, Jaroslav Turanek, Petr Maly, Milan Raska
Publikováno v:
EBioMedicine, Vol 47, Iss , Pp 247-256 (2019)
Background: The development of an effective vaccine preventing HIV-1 infection is hindered by the enormous antigenic variability and unique biochemical and immunological properties of HIV-1 Env glycoprotein, the most promising target for HIV-1 neutra
Externí odkaz:
https://doaj.org/article/766038e16e974b7fb6d548862f5e1bfd
Publikováno v:
Cytokine & Growth Factor Reviews. 66:1-14
IL-6 is considered one of the well characterized cytokines exhibiting homeostatic, pro- and anti-inflammatory activities, depending on the receptor variant and the induced intracellular cis- or trans-signaling responses. IL-6-activated pathways are i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6392e83ce97b1289b0083a52351a809
https://doi.org/10.1016/j.cytogfr.2022.04.001
https://doi.org/10.1016/j.cytogfr.2022.04.001
Autor:
Milan Kuchař, Kristýna Sloupenská, Leona Rašková Kafková, Yaroslava Groza, Jozef Škarda, Petr Kosztyu, Marie Hlavničková, Joanna M. Mierzwicka, Radim Osička, Hana Petroková, Stephen I. Walimbwa, Shiv Bharadwaj, Jiří Černý, Milan Raška, Petr Malý
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-20 (2024)
Abstract Background Human interleukin-22 (IL-22) is known as a “dual function” cytokine that acts as a master regulator to maintain homeostasis, structural integrity of the intestinal epithelial barrier, and shielding against bacterial pathogens.
Externí odkaz:
https://doaj.org/article/7572fe8ba3d04303a546ae87cac08392
Autor:
Yaroslava Groza, Lukáš Lacina, Milan Kuchař, Leona Rašková Kafková, Kateřina Zachová, Olga Janoušková, Radim Osička, Jiří Černý, Hana Petroková, Joanna Maria Mierzwicka, Natalya Panova, Petr Kosztyu, Kristýna Sloupenská, Jan Malý, Jozef Škarda, Milan Raška, Karel Smetana, Petr Malý
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-26 (2024)
Abstract Background Interleukin-6 (IL-6) is a multifunctional cytokine that controls the immune response, and its role has been described in the development of autoimmune diseases. Signaling via its cognate IL-6 receptor (IL-6R) complex is critical i
Externí odkaz:
https://doaj.org/article/60f3248bbe5d4cae877f072b508159d0
Autor:
Joanna Maria Mierzwicka, Hana Petroková, Leona Rašková Kafková, Petr Kosztyu, Jiří Černý, Milan Kuchař, Miloš Petřík, Kateřina Bendová, Kristýna Krasulová, Yaroslava Groza, Lucie Vaňková, Shiv Bharadwaj, Natalya Panova, Michal Křupka, Jozef Škarda, Milan Raška, Petr Malý
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-19 (2024)
Abstract Background Programmed cell death 1 (PD-1) belongs to immune checkpoint proteins ensuring negative regulation of the immune response. In non-small cell lung cancer (NSCLC), the sensitivity to treatment with anti-PD-1 therapeutics, and its eff
Externí odkaz:
https://doaj.org/article/12d21b9a3d6c426188cee02bbd727d27
Publikováno v:
Communications Physics, Vol 7, Iss 1, Pp 1-7 (2024)
Abstract Nonlinear optical response of solid-state materials exposed to strong non-resonant light fields leads to the generation of harmonic frequencies as a consequence of interband polarization and coherent intraband dynamics of the electrons. The
Externí odkaz:
https://doaj.org/article/d409ad59514b49af820c11e107ece127
Autor:
Marek Maly, Jiri Cerny, Petr Kosztyu, Petr Maly, Lucia Barkocziova, Jaroslav Turánek, Pavlína Turánek Knotigová, Veronika Liskova, Milan Raska, Lýdie Czerneková, Josef Mašek, Milan Kuchar, Hana Petroková, L. Raskova Kafkova
Publikováno v:
EBioMedicine. 47:247-256
Background: The development of effective vaccine preventing HIV-1 infection is hindered by enormous antigenic variability and unique biochemical and immunological properties of HIV-1 Env glycoprotein, the most promising target for HIV-1 neutralizing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f075bb9958cbb1ee767c8f7cfbd899c2
https://doi.org/10.1016/j.ebiom.2019.07.015
https://doi.org/10.1016/j.ebiom.2019.07.015
Publikováno v:
Sensors and Actuators B: Chemical. 272:441-447
Recent developments in molecular evolution technologies have led to novel types of high-affinity recombinant protein binders (PB) able to substitute antibodies in many diagnostic and therapeutic applications. Despite almost a decade of research, they
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2be0cef6c9cbd3a694a25df905fc0802
https://doi.org/10.1016/j.snb.2018.05.180
https://doi.org/10.1016/j.snb.2018.05.180