Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Petr Knesl"'
Publikováno v:
Molecules, Vol 11, Iss 4, Pp 286-297 (2006)
The synthesis of three substituted 6,7-dihydroxy-4-quinazolineamines: tandutinib (1), erlotinib (2) and gefitinib (3) in improved yields is reported. The intermediates were characterized by NMR and the purities determined by HPLC.
Externí odkaz:
https://doaj.org/article/1232ce989d614efd9c69381f023ff21e
Autor:
Birgit Wilding, Dirk Scharn, Dietrich Böse, Anke Baum, Valeria Santoro, Paolo Chetta, Renate Schnitzer, Dana A. Botesteanu, Christoph Reiser, Stefan Kornigg, Petr Knesl, Alexandra Hörmann, Anna Köferle, Maja Corcokovic, Simone Lieb, Guido Scholz, Jens Bruchhaus, Markus Spina, Josef Balla, Biljana Peric-Simov, Jasmin Zimmer, Sophie Mitzner, Thomas N. Fett, Alexandra Beran, Lyne Lamarre, Thomas Gerstberger, Daniel Gerlach, Markus Bauer, Andreas Bergner, Andreas Schlattl, Gerd Bader, Matthias Treu, Harald Engelhardt, Stephan Zahn, Julian E. Fuchs, Johannes Zuber, Peter Ettmayer, Mark Pearson, Mark Petronczki, Norbert Kraut, Darryl B. McConnell, Flavio Solca, Ralph A. Neumüller
Publikováno v:
Nature cancer. 3(7)
Oncogenic alterations in human epidermal growth factor receptor 2 (HER2) occur in approximately 2% of patients with non-small cell lung cancer and predominantly affect the tyrosine kinase domain and cluster in exon 20 of the ERBB2 gene. Most clinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a57bd9ab03550201530aeff623cc359c
https://pubmed.ncbi.nlm.nih.gov/35883002
https://pubmed.ncbi.nlm.nih.gov/35883002
Autor:
Andreas Schrenk, Daniela Häring, Silke Fischer, Stefan Kornigg, Alex G. Waterson, Andreas Mantoulidis, Manfred Koegl, Markus Zeeb, Thomas Gerstberger, Mark Pearson, Wolfgang Hela, Andreas Zoephel, Darryl B. McConnell, Michael Gmachl, Bernadette Sharps, Jale Karolyi-Oezguer, Johann Hoffmann, Franziska Moser, Jason Phan, Teresa Gmaschitz, David Covini, Bernhard Wolkerstorfer, Qi Sun, Lyne Lamarre, Gabriella Siszler, Renate Schnitzer, Moriz Mayer, Dirk Kessler, Katharina Schipany, Petr Knesl, Christian Salamon, Peter Greb, Stephen W. Fesik, Andreas Gollner, Yvonne Scherbantin, Silvia Munico-Martinez, Craig M. Goodwin, Roland Kousek, Jörg Rinnenthal, Jiqing Sai, Christoph Peinsipp, Laetitia J. Martin
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Despite decades of research, no approved drugs have been discovered for KRAS. Recently, a pocket occurring on the surface of the active and inactive form of KRAS was found, but, due to its comparatively shallow, polar nature, this pocket
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cb3a3b7c6eb6eb9f74dfaa7050cde56
https://pubmed.ncbi.nlm.nih.gov/32047043
https://pubmed.ncbi.nlm.nih.gov/32047043
Publikováno v:
Tetrahedron Letters. 47:5701-5703
The synthesis of racemic 8-fluorogalanthamine and its separation into (−)- and (+)-8-fluorogalanthamine (= (4a S ,6 R ,8a S )- and (4a R ,6 S ,8a R )-1-fluoro-4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-6 H -benzofuro[3 a ,3,2- ef ][2]benzazepin-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2ab77980113d7fd71e72b2c34373e9e
https://doi.org/10.1016/j.tetlet.2006.06.010
https://doi.org/10.1016/j.tetlet.2006.06.010
Autor:
Ulrich Jordis, Petr Knesl
Publikováno v:
Proceedings of The 9th International Electronic Conference on Synthetic Organic Chemistry.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1d0cb489d63ab9f5941cb0a82605644
https://doi.org/10.3390/ecsoc-9-01516
https://doi.org/10.3390/ecsoc-9-01516