Zobrazeno 1 - 10
of 200
pro vyhledávání: '"Petr Ježek"'
Autor:
Martin Jabůrek, Eduardo Klöppel, Pavla Průchová, Oleksandra Mozheitova, Jan Tauber, Hana Engstová, Petr Ježek
Publikováno v:
Redox Biology, Vol 75, Iss , Pp 103283- (2024)
We asked whether acute redox signaling from mitochondria exists concomitantly to fatty acid- (FA-) stimulated insulin secretion (FASIS) at low glucose by pancreatic β-cells. We show that FA β-oxidation produces superoxide/H2O2, providing: i) mitoch
Externí odkaz:
https://doaj.org/article/2c62519b300e44dfa58a44a1a60d3131
Autor:
Klára Gotvaldová, Jitka Špačková, Jiří Novotný, Kamila Baslarová, Petr Ježek, Lenka Rossmeislová, Jan Gojda, Katarína Smolková
Publikováno v:
Cancer & Metabolism, Vol 12, Iss 1, Pp 1-18 (2024)
Abstract Background Pancreatic ductal adenocarcinoma (PDAC) has been associated with the host dysmetabolism of branched-chain amino acids (BCAAs), however, the implications for the role of BCAA metabolism in PDAC development or progression are not cl
Externí odkaz:
https://doaj.org/article/9c8e633d23934de4801d995632b21d73
Autor:
Ason C. Y. Chiang, Jan Ježek, Peiqiang Mu, Ying Di, Anna Klucnika, Martin Jabůrek, Petr Ježek, Hansong Ma
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Genetic screens have been used extensively to probe interactions between nuclear genes and their impact on phenotypes. Probing interactions between mitochondrial genes and their phenotypic outcome, however, has not been possible due to a lac
Externí odkaz:
https://doaj.org/article/535c6d0b32ad4ccfa77fbdd9ef88c699
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-19 (2023)
Abstract Previously, a number of ~ 1.4 of mitochondrial DNA (mtDNA) molecules in a single nucleoid was reported, which would reflect a minimum nucleoid division. We applied 3D-double-color direct stochastic optical reconstruction microscopy (dSTORM),
Externí odkaz:
https://doaj.org/article/11d4c7119b4b4b58a18f60cf7ee25933
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Pancreatic-β-cell-specifying transcription factor Nkx6.1, indispensable for embryonic development of the pancreatic epithelium and commitment to β-cell lineage, directly controls the expression of a glucose transporter (Glut2), pyruvate ca
Externí odkaz:
https://doaj.org/article/242b49292f1641c19aed45be9d917bce
Autor:
Viktoriia Oleksa, Hana Macková, Hana Engstová, Vitalii Patsula, Oleksandr Shapoval, Nadiia Velychkivska, Petr Ježek, Daniel Horák
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Upconverting luminescent lanthanide-doped nanoparticles (UCNP) belong to promising new materials that absorb infrared light able to penetrate in the deep tissue level, while emitting photons in the visible or ultraviolet region, which makes
Externí odkaz:
https://doaj.org/article/3926a4cf2c6943d0a8d89ae0a6251de7
Autor:
Petr Ježek
Publikováno v:
Antioxidants, Vol 12, Iss 9, p 1696 (2023)
Redox signaling from mitochondria (mt) to the cytosol and plasma membrane (PM) has been scarcely reported, such as in the case of hypoxic cell adaptation or (2-oxo-) 2-keto-isocaproate (KIC) β-like-oxidation stimulating insulin secretion in pancreat
Externí odkaz:
https://doaj.org/article/f4f1f106760947d291022a68bfd49dd8
Autor:
Katarína Smolková, Jitka Špačková, Klára Gotvaldová, Aleš Dvořák, Alena Křenková, Martin Hubálek, Blanka Holendová, Libor Vítek, Petr Ježek
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Abstract Wild type mitochondrial isocitrate dehydrogenase (IDH2) was previously reported to produce oncometabolite 2-hydroxyglutarate (2HG). Besides, mitochondrial deacetylase SIRT3 has been shown to regulate the oxidative function of IDH2. However,
Externí odkaz:
https://doaj.org/article/20506b7cea8046529d75499febad66a9
Publikováno v:
Frontiers in Neuroinformatics, Vol 14 (2020)
The Neurodata Without Borders (abbreviation NWB) format is a current technology for storing neurophysiology data along with the associated metadata. Data stored in the format is organized into separate HDF5 files, each file usually storing the data a
Externí odkaz:
https://doaj.org/article/a07d2d12dcda4cb18aa3db05a7c3c8b2
Autor:
Uliana Kostiv, Hana Engstová, Bartosz Krajnik, Miroslav Šlouf, Vladimír Proks, Artur Podhorodecki, Petr Ježek, Daniel Horák
Publikováno v:
Frontiers in Chemistry, Vol 8 (2020)
Lanthanide-doped upconversion nanoparticles (UCNPs) have a unique capability of upconverting near-infrared (NIR) excitation into ultraviolet, visible, and NIR emission. Conventional UCNPs composed of NaYF4:Yb3+/Er3+(Tm3+) are excited by NIR light at
Externí odkaz:
https://doaj.org/article/177587c8949f4bb9bf23ef950e1ab384