Zobrazeno 1 - 10
of 126
pro vyhledávání: '"Petr Hodek"'
Publikováno v:
Cosmetics, Vol 11, Iss 2, p 33 (2024)
Cytochrome P450 (CYP) enzymes play a key role in the metabolism of foreign compounds and in the biosynthesis and catabolism of endogenous substances, including hormones. The activity of these enzymes can be affected by various xenobiotics, such as po
Externí odkaz:
https://doaj.org/article/68de8717ba484b91843d38ec5e0ca848
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 145, Iss , Pp 112391- (2022)
Lenvatinib, a small molecule tyrosine kinase inhibitor (TKI), exhibits good inhibitory effect in several types of carcinomas. Specifically, it is the most effective TKI used for treatment of thyroid cancer. To extend pharmacokinetics data on this ant
Externí odkaz:
https://doaj.org/article/2f244a7545cb4a5faf7f44487ac55988
Autor:
Kateřina Bělonožníková, Eliška Sladkovská, Daniel Kavan, Veronika Hýsková, Petr Hodek, Daniel Šmíd, Helena Ryšlavá
Publikováno v:
Molecules, Vol 28, Iss 3, p 1019 (2023)
Pseudomonas aeruginosa is one of the most antibiotic multi-resistant bacteria, causing chronic pulmonary disease and leading to respiratory failure and even mortality. Thus, there has been an ever-increasing search for novel and preferably natural an
Externí odkaz:
https://doaj.org/article/a82a77ae8f0b43af95aacf8f920c95d7
Autor:
František Bárta, Alena Dedíková, Michaela Bebová, Šárka Dušková, Jaroslav Mráz, Heinz H. Schmeiser, Volker M. Arlt, Petr Hodek, Marie Stiborová
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 19, p 10479 (2021)
The plant extract aristolochic acid (AA), containing aristolochic acids I (AAI) and II (AAII) as major components, causes aristolochic acid nephropathy (AAN) and Balkan endemic nephropathy (BEN), unique renal diseases associated with upper urothelial
Externí odkaz:
https://doaj.org/article/67a119f84dac49abadf36061f010ca65
Autor:
Kateřina Jáklová, Tereza Feglarová, Simona Rex, Zbyněk Heger, Tomáš Eckschlager, Jan Hraběta, Petr Hodek, Matúš Kolárik, Radek Indra
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 8, p 4250 (2021)
A tyrosine kinase inhibitor, vandetanib (Van), is an anticancer drug affecting the signaling of VEGFR, EGFR and RET protooncogenes. Van is primarily used for the treatment of advanced or metastatic medullary thyroid cancer; however, its usage is sign
Externí odkaz:
https://doaj.org/article/396c504b67bd4c449cfa0abb83b41c12
Publikováno v:
Biomedicines, Vol 8, Iss 12, p 547 (2020)
Herein, the in vitro metabolism of tyrosine kinase inhibitor cabozantinib, the drug used for the treatment of metastatic medullary thyroid cancer and advanced renal cell carcinoma, was studied using hepatic microsomal samples of different human donor
Externí odkaz:
https://doaj.org/article/a49d55891bc547c19c2ebc52e3eb3fd4
Autor:
Marie Stiborová, František Bárta, Kateřina Levová, Petr Hodek, Heinz H. Schmeiser, Volker M. Arlt, Václav Martínek
Publikováno v:
International Journal of Molecular Sciences, Vol 16, Iss 11, Pp 27561-27575 (2015)
Aristolochic acid I (AAI) is a plant alkaloid causing aristolochic acid nephropathy, Balkan endemic nephropathy and their associated urothelial malignancies. AAI is detoxified by cytochrome P450 (CYP)-mediated O-demethylation to 8-hydroxyaristolochic
Externí odkaz:
https://doaj.org/article/deb96ba69f364149b998d2bdee98daab
Publikováno v:
Prague Medical Report, Vol 116, Iss 1, Pp 16-23 (2015)
Isolated porcine pepsinogen A was used for the preparation of polyclonal rabbit and polyclonal chicken anti-pepsinogen A antibodies. Immunochemical properties of both immunoglobulin fractions were compared. The rabbit anti-serum was further purified
Externí odkaz:
https://doaj.org/article/2753f8f6b6824468942d3db2c8bc43e5
Autor:
Libuše Nosková, Božena Kubíčková, Lucie Vašková, Barbora Bláhová, Michaela Wimmerová, Marie Stiborová, Petr Hodek
Publikováno v:
Sensors, Vol 15, Iss 1, Pp 1945-1953 (2015)
Antibodies against Pseudomonas aeruginosa (PA) lectin, PAIIL, which is a virulence factor mediating the bacteria binding to epithelium cells, were prepared in chickens and purified from egg yolks. To examine these antibodies as a prophylactic agent p
Externí odkaz:
https://doaj.org/article/e40418ec02ec4759b629651920a1e5e3
Publikováno v:
Sensors, Vol 14, Iss 12, Pp 22982-22997 (2014)
The requirements for early diagnostics as well as effective treatment of cancer diseases have increased the pressure on development of efficient methods for targeted drug delivery as well as imaging of the treatment success. One of the most recent ap
Externí odkaz:
https://doaj.org/article/78223966f3a34148bf3df5347575f2ee