Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Petr Hezký"'
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 59:615-618
The radioactively labelled 6-amino-5-nitroso-uracil (1) and 5-acetyl-6-amino-1,3-dimethyl-uracil (2) were required for metabolic studies to assess their suitability as drug candidates. A common precursor for both compounds was [cyano-14 C]cyanoacetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::619c9669113a114fe761fff32297f1d0
https://doi.org/10.1002/jlcr.3405
https://doi.org/10.1002/jlcr.3405
Publikováno v:
Journal of labelled compoundsradiopharmaceuticals. 59(14)
The radioactively labelled 6-amino-5-nitroso-uracil (1) and 5-acetyl-6-amino-1,3-dimethyl-uracil (2) were required for metabolic studies to assess their suitability as drug candidates. A common precursor for both compounds was [cyano
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::76e5395d908eb727bbced6dd3322a91e
https://pubmed.ncbi.nlm.nih.gov/27197875
https://pubmed.ncbi.nlm.nih.gov/27197875
Publikováno v:
ResearcherID
New derivatives of anpirtoline and deazaanpirtoline modified in the side chain have been synthesized. The series includes compounds 3 with side-chains containing piperidine or pyrrolidine rings, compounds 4 containing 8-azabicyclo[3.2.1]octane moiety
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a6144629b73735f5a06ed2653a3e200
https://doi.org/10.1002/(sici)1521-4184(20005)333:5<107::aid-ardp107>3.0.co
https://doi.org/10.1002/(sici)1521-4184(20005)333:5<107::aid-ardp107>3.0.co
Publikováno v:
Scopus-Elsevier
2-Benzoyl- and 2-(pyridylcarbonyl)-1-benzofuran-3-amines were prepared from 2-hydroxybenzonitrile and corresponding bromoethanone derivatives. 2-Benzoyl- and 2-(pyridylcarbonyl)-1-benzothiophene-3-amines were prepared analogously from 2-sulfanylbenzo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d90fa82e516d8b88c82ee9ace7d8cd3d
https://doi.org/10.1135/cccc20001093
https://doi.org/10.1135/cccc20001093
Publikováno v:
Scopus-Elsevier
Molecular modification of anpirtoline (2a) is described. Several methods of preparation of 4-[(3-chlorophenyl)sulfanyl]-1-methylpiperidine (3a) and its demethylation led to the deazaanpirtoline (3c). Nucleophilic substitution of piperidine-4-thiole w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0761e707645b520d72a1aa61f40d899e
https://doi.org/10.1135/cccc19990363
https://doi.org/10.1135/cccc19990363
Publikováno v:
Bioorganicmedicinal chemistry letters. 10(1)
A series of epibatidine analogues and their positional isomers bearing an 8-azabicyclo[3.2.1]octane moiety is described. Some of the compounds, especially those containing 8-azabicyclo[3.2.1]oct-2-ene moiety show high affinity for the nicotinic choli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c4d9c5d08ecc47125b9fb84e2041e92
https://pubmed.ncbi.nlm.nih.gov/10636243
https://pubmed.ncbi.nlm.nih.gov/10636243
Publikováno v:
Scopus-Elsevier
3-Unsubstituted 1-benzofurans 1e and 1f, 3-methyl-1-benzofurans 1a-1d, and 3-amino-1-benzofurans 2a-2l, as well as 3-amino-1-benzothiophenes 3a, 3b and 3-aminoindoles 4a-4f, 11a, and 11b were prepared and tested as analgesics. The 3-amino-1-benzofura
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70a6cd5738f8db58bad2c19cacf368fe
http://www.scopus.com/inward/record.url?eid=2-s2.0-0034344030&partnerID=MN8TOARS
http://www.scopus.com/inward/record.url?eid=2-s2.0-0034344030&partnerID=MN8TOARS
Publikováno v:
Scopus-Elsevier
Derivatives of 2-chloro-6-(4-hydroxy-1-methylpiperidin-4-yl)pyridine (2b) were prepared and tested as analgesics. 2-Chloro-6-lithiopyridine treated with quinuclidin-3-one, 1-methylpyrrolidin-3-one, 2-(dimethylaminomethyl)cyclohexanone, and ethyl 1-me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f421ac7b9423698ad408fe465958d47a
http://www.scopus.com/inward/record.url?eid=2-s2.0-0033241280&partnerID=MN8TOARS
http://www.scopus.com/inward/record.url?eid=2-s2.0-0033241280&partnerID=MN8TOARS
Publikováno v:
Scopus-Elsevier
ResearcherID
ResearcherID
Synthesis of arylpiperideines 3a-3d and arylpiperidines 4a-4d as analogs of a well known serotonin ligand 1-(3-chlorophenyl)piperazine is reported. Starting aryllithium derivatives were treated with 1-methyl-piperdin-4-one to provide the correspondin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f50477941a0708e70310014559eca73
http://www.scopus.com/inward/record.url?eid=2-s2.0-0032853485&partnerID=MN8TOARS
http://www.scopus.com/inward/record.url?eid=2-s2.0-0032853485&partnerID=MN8TOARS