Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Petr G. Leiman"'
Autor:
Ravi R. Sonani, Lee K. Palmer, Nathaniel C. Esteves, Abigail A. Horton, Amanda L. Sebastian, Rebecca J. Kelly, Fengbin Wang, Mark A. B. Kreutzberger, William K. Russell, Petr G. Leiman, Birgit E. Scharf, Edward H. Egelman
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract A contractile sheath and rigid tube assembly is a widespread apparatus used by bacteriophages, tailocins, and the bacterial type VI secretion system to penetrate cell membranes. In this mechanism, contraction of an external sheath powers the
Externí odkaz:
https://doaj.org/article/8ffa8b55ddc8423ca2316eb1e94a3daa
Autor:
Ravi R. Sonani, Nathaniel C. Esteves, Abigail A. Horton, Rebecca J. Kelly, Amanda L. Sebastian, Fengbin Wang, Mark A. B. Kreutzberger, Petr G. Leiman, Birgit E. Scharf, Edward H. Egelman
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-12 (2023)
Abstract Large gaps exist in our understanding of how bacteriophages, the most abundant biological entities on Earth, assemble and function. The structure of the “neck” region, where the DNA-filled capsid is connected to the host-recognizing tail
Externí odkaz:
https://doaj.org/article/0740d9f71f894ffeb7fdec6eddb67909
Autor:
Alec Fraser, Maria L. Sokolova, Arina V. Drobysheva, Julia V. Gordeeva, Sergei Borukhov, John Jumper, Konstantin V. Severinov, Petr G. Leiman
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Promoter recognition is a critical step in the initiation of transcription of DNA to RNA. Here, the authors describe a novel mechanism by which a phage-encoded RNA polymerase recognizes viral promoters containing deoxyuridines instead of thymidines.
Externí odkaz:
https://doaj.org/article/721111b55e21403f9a09179504ea30f4
Publikováno v:
Frontiers in Microbiology, Vol 10 (2019)
Klebsiella pneumoniae carries a thick polysaccharide capsule. This highly variable chemical structure plays an important role in its virulence. Many Klebsiella bacteriophages recognize this capsule with a receptor binding protein (RBP) that contains
Externí odkaz:
https://doaj.org/article/bb2ffbeb6b62480f8469206af784e14d
Publikováno v:
Viruses, Vol 12, Iss 10, p 1135 (2020)
Infecting bacteriophage T4 uses a contractile tail structure to breach the envelope of the Escherichia coli host cell. During contraction, the tail tube headed with the “central spike complex” is thought to mechanically puncture the outer membran
Externí odkaz:
https://doaj.org/article/78bb2135848b474481e6eafbe0077fd1
Publikováno v:
Viruses, Vol 12, Iss 10, p 1070 (2020)
The bacteriophage T4 genome contains two genes that code for proteins with lysozyme activity—e and 5. Gene e encodes the well-known T4 lysozyme (commonly called T4L) that functions to break the peptidoglycan layer late in the infection cycle, which
Externí odkaz:
https://doaj.org/article/52b215a8d5264eb790ee8e06dfe8fbf6
Autor:
Sergey A. Buth, Laure Menin, Mikhail M. Shneider, Jürgen Engel, Sergei P. Boudko, Petr G. Leiman
Publikováno v:
Viruses, Vol 7, Iss 8, Pp 4676-4706 (2015)
Gene product 5 (gp5) of bacteriophage T4 is a spike-shaped protein that functions to disrupt the membrane of the target cell during phage infection. Its C-terminal domain is a long and slender β-helix that is formed by three polypeptide chains wrapp
Externí odkaz:
https://doaj.org/article/a5478a753bed4882abcb3d1de7f2f001
Publikováno v:
Viruses, Vol 10, Iss 8, p 427 (2018)
The R-type pyocins are high-molecular weight bacteriocins produced by some strains of Pseudomonas aeruginosa to specifically kill other strains of the same species. Structurally, the R-type pyocins are similar to “simple” contractile tails, such
Externí odkaz:
https://doaj.org/article/e5b2afce27cb468e85833555aee5ec9e
Autor:
John-Mark Miller, Ekaterina S. Knyazhanskaya, Sergii A. Buth, Nikolai S. Prokhorov, Petr G. Leiman
Publikováno v:
bioRxiv
The contractile tail of bacteriophage P2 functions to drive the tail tube across the outer membrane of its host bacterium, a prerequisite event for subsequent translocation of phage genomic DNA into the host cell. The tube is equipped with a spike-sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8a9192fe7e4adc9c0ee86d66a8a2aea
https://doi.org/10.1101/2023.02.25.529910
https://doi.org/10.1101/2023.02.25.529910
Autor:
Reinhard Albrecht, Inokentijs Josts, Daniel C. Nelson, Petr G. Leiman, Sara B. Linden, Steven D. Rees, Andriy Kryshtafovych, Kinlin L. Chao, Osnat Herzberg, Geoffrey Chang, John Moult, Andrei N. Lupas, Alec Fraser, Marcus D. Hartmann, Alpha Fold team, Julia Greenfield, Henning Tidow, Maria L. Sokolova, Xiaoran Shang
Publikováno v:
Proteins
Critical assessment of structure prediction (CASP) conducts community experiments to determine the state of the art in computing protein structure from amino acid sequence. The process relies on the experimental community providing information about
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::697f2aff4856d823bda631bd34762686
https://doi.org/10.1002/prot.26223
https://doi.org/10.1002/prot.26223