Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Petr Flachs"'
Autor:
Ondrej Mihola, Vladimir Landa, Florencia Pratto, Kevin Brick, Tatyana Kobets, Fitore Kusari, Srdjan Gasic, Fatima Smagulova, Corinne Grey, Petr Flachs, Vaclav Gergelits, Karel Tresnak, Jan Silhavy, Petr Mlejnek, R. Daniel Camerini-Otero, Michal Pravenec, Galina V. Petukhova, Zdenek Trachtulec
Publikováno v:
BMC Biology, Vol 19, Iss 1, Pp 1-20 (2021)
Abstract Background Vertebrate meiotic recombination events are concentrated in regions (hotspots) that display open chromatin marks, such as trimethylation of lysines 4 and 36 of histone 3 (H3K4me3 and H3K36me3). Mouse and human PRDM9 proteins catal
Externí odkaz:
https://doaj.org/article/03a0d82fd99840bf996152ad7bf19c03
Publikováno v:
Nucleus, Vol 10, Iss 1, Pp 93-115 (2019)
During meiosis, homologous chromosomes undergo a dramatic movement in order to correctly align. This is a critical meiotic event but the molecular properties of this ‘chromosomal dance’ still remainunclear. We identified DEB-1 – an orthologue o
Externí odkaz:
https://doaj.org/article/369830f0ab1c422d88391d2ce9a0b246
Autor:
Jana Petrusová, Robert Havalda, Petr Flachs, Tomáš Venit, Alžběta Darášová, Lenka Hůlková, Martin Sztacho, Pavel Hozák
Publikováno v:
Cells, Vol 11, Iss 13, p 2013 (2022)
The focal adhesion protein Vinculin (VCL) is ascribed to various cytoplasmic functions; however, its nuclear role has so far been ambiguous. We observed that VCL localizes to the nuclei of mouse primary spermatocytes undergoing first meiotic division
Externí odkaz:
https://doaj.org/article/af4d930759aa4f2d95c412a0ccbdf9d8
Autor:
Christopher L Baker, Pavlina Petkova, Michael Walker, Petr Flachs, Ondrej Mihola, Zdenek Trachtulec, Petko M Petkov, Kenneth Paigen
Publikováno v:
PLoS Genetics, Vol 11, Iss 9, p e1005512 (2015)
Genetic recombination during meiosis functions to increase genetic diversity, promotes elimination of deleterious alleles, and helps assure proper segregation of chromatids. Mammalian recombination events are concentrated at specialized sites, termed
Externí odkaz:
https://doaj.org/article/9d4cabb3f38d426994cbdbc5144ef1d2
Autor:
Petr Flachs, Tanmoy Bhattacharyya, Ondřej Mihola, Jaroslav Piálek, Jiří Forejt, Zdenek Trachtulec
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e95806 (2014)
PR-domain 9 (Prdm9) is the first hybrid sterility gene identified in mammals. The incompatibility between Prdm9 from Mus musculus domesticus (Mmd; the B6 strain) and the Hstx2 region of chromosome (Chr) X from M. m. musculus (Mmm; the PWD strain) par
Externí odkaz:
https://doaj.org/article/f779737577da40598a781a7a64621e75
Autor:
Petr Flachs, Ondřej Mihola, Petr Simeček, Soňa Gregorová, John C Schimenti, Yasuhisa Matsui, Frédéric Baudat, Bernard de Massy, Jaroslav Piálek, Jiří Forejt, Zdenek Trachtulec
Publikováno v:
PLoS Genetics, Vol 8, Iss 11, p e1003044 (2012)
The Dobzhansky-Muller model of incompatibilities explains reproductive isolation between species by incorrect epistatic interactions. Although the mechanisms of speciation are of great interest, no incompatibility has been characterized at the gene l
Externí odkaz:
https://doaj.org/article/37c688b497cd41a4b268bbff67848644
Autor:
Florencia Pratto, R. Daniel Camerini-Otero, Tatyana Kobets, Ondrej Mihola, Christopher L. Baker, Kevin Brick, Petko M. Petkov, Eliska Linhartova, Kenneth Paigen, Zdenek Trachtulec, Petr Flachs, Radislav Sedlacek
Publikováno v:
Genome Research. 29:1078-1086
A hallmark of meiosis is the rearrangement of parental alleles to ensure genetic diversity in the gametes. These chromosome rearrangements are mediated by the repair of programmed DNA double-strand breaks (DSBs) as genetic crossovers between parental
Publikováno v:
Nucleus, Vol 10, Iss 1, Pp 93-115 (2019)
Nucleus
Nucleus
During meiosis, homologous chromosomes undergo a dramatic movement in order to correctly align. This is a critical meiotic event but the molecular properties of this ‘chromosomal dance’ still remainunclear. We identified DEB-1 – an orthologue o
Autor:
Vladimír Landa, Fatima Smagulova, Florencia Pratto, Ondrej Mihola, Michal Pravenec, Srdjan Gasic, R. Daniel Camerini-Otero, Petr Flachs, Corinne Grey, Fitore Kusari, Karel Tresnak, Vaclav Gergelits, Galina V. Petukhova, Petr Mlejnek, Zdenek Trachtulec, Tatyana Kobets, Kevin Brick, Jan Silhavy
Publikováno v:
BMC Biology
BMC Biology, Vol 19, Iss 1, Pp 1-20 (2021)
BMC Biology, 2021, 19 (1), pp.86. ⟨10.1186/s12915-021-01017-0⟩
BMC Biology, BioMed Central, 2021, 19 (1), pp.86. ⟨10.1186/s12915-021-01017-0⟩
BMC Biology, Vol 19, Iss 1, Pp 1-20 (2021)
BMC Biology, 2021, 19 (1), pp.86. ⟨10.1186/s12915-021-01017-0⟩
BMC Biology, BioMed Central, 2021, 19 (1), pp.86. ⟨10.1186/s12915-021-01017-0⟩
BackgroundVertebrate meiotic recombination events are concentrated in regions (hotspots) that display open chromatin marks, such as trimethylation of lysines 4 and 36 of histone 3 (H3K4me3 and H3K36me3). Mouse and human PRDM9 proteins catalyze H3K4me
Autor:
Zdenek Trachtulec, Petko M. Petkov, Christopher L. Baker, Ondrej Mihola, Kenneth Paigen, Pavlina Petkova, Michael G. Walker, Petr Flachs
Publikováno v:
PLoS Genetics, Vol 11, Iss 9, p e1005512 (2015)
PLoS Genetics
PLoS Genetics
Genetic recombination during meiosis functions to increase genetic diversity, promotes elimination of deleterious alleles, and helps assure proper segregation of chromatids. Mammalian recombination events are concentrated at specialized sites, termed