Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Petr Chlapek"'
Autor:
Polina Kameneva, Victoria I. Melnikova, Maria Eleni Kastriti, Anastasia Kurtova, Emil Kryukov, Aliia Murtazina, Louis Faure, Irina Poverennaya, Artem V. Artemov, Tatiana S. Kalinina, Nikita V. Kudryashov, Michael Bader, Jan Skoda, Petr Chlapek, Lucie Curylova, Lukas Sourada, Jakub Neradil, Marketa Tesarova, Massimo Pasqualetti, Patricia Gaspar, Vasily D. Yakushov, Boris I. Sheftel, Tomas Zikmund, Jozef Kaiser, Kaj Fried, Natalia Alenina, Elena E. Voronezhskaya, Igor Adameyko
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)
Adrenal glands are major organs regulating stress response., Melnikova et al., show that local release of serotonin limits adrenalin-producing cell number during rodent development, a mechanism which has implications for neuroblastoma development and
Externí odkaz:
https://doaj.org/article/ca903ec136424382bd20c84f80eea462
Autor:
Maria Krchniakova, Silvia Paukovcekova, Petr Chlapek, Jakub Neradil, Jan Skoda, Renata Veselska
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Tyrosine kinase inhibitors (TKIs) are frequently used in combined therapy to enhance treatment efficacy and overcome drug resistance. The present study analyzed the effects of three inhibitors, sunitinib, gefitinib, and lapatinib, combined with iron-
Externí odkaz:
https://doaj.org/article/953b01435918483ea1b53ad2f28c8d72
Autor:
Silvia Paukovcekova, Maria Krchniakova, Petr Chlapek, Jakub Neradil, Jan Skoda, Renata Veselska
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 15, p 8549 (2022)
Anticancer therapy by anthracyclines often leads to the development of multidrug resistance (MDR), with subsequent treatment failure. Thiosemicarbazones have been previously suggested as suitable anthracycline partners due to their ability to overcom
Externí odkaz:
https://doaj.org/article/cd0f2fcf973e486fa0b9fac94da67dfd
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-13 (2018)
Abstract For decades, retinoids and their synthetic derivatives have been well established anticancer treatments due to their ability to regulate cell growth and induce cell differentiation and apoptosis. Many studies have reported the promising role
Externí odkaz:
https://doaj.org/article/2079bfc87e0544c68564cd815a548ef1
Autor:
Helena Ramos, Maria I.L. Soares, Joana Silva, Liliana Raimundo, Juliana Calheiros, Célia Gomes, Flávio Reis, Filipe A. Monteiro, Cláudia Nunes, Salette Reis, Bartolomeo Bosco, Silvano Piazza, Lucília Domingues, Petr Chlapek, Petr Vlcek, Pavel Fabian, Ana Teresa Rajado, A.T.P. Carvalho, Renata Veselska, Alberto Inga, Teresa M.V.D. Pinho e Melo, Lucília Saraiva
Publikováno v:
Cell Reports, Vol 35, Iss 2, Pp 108982- (2021)
Summary: Impairment of the p53 pathway is a critical event in cancer. Therefore, reestablishing p53 activity has become one of the most appealing anticancer therapeutic strategies. Here, we disclose the p53-activating anticancer drug (3S)-6,7-bis(hyd
Externí odkaz:
https://doaj.org/article/49516e7fa22e429b9dc9fbabff3cfc73
Autor:
Renata Veselska, Marta Jezova, Michal Kyr, Pavel Mazanek, Petr Chlapek, Viera Dobrotkova, Jaroslav Sterba
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
The survival rate for patients with high-risk neuroblastomas remains poor despite new improvements in available therapeutic modalities. A detailed understanding of the mechanisms underlying clinical responses to multimodal treatment is one of the imp
Externí odkaz:
https://doaj.org/article/cc77f362613344c78f1a26281eb21144
Autor:
Viera Dobrotkova, Petr Chlapek, Marta Jezova, Katerina Adamkova, Pavel Mazanek, Jaroslav Sterba, Renata Veselska
Publikováno v:
PLoS ONE, Vol 14, Iss 6, p e0218269 (2019)
Although the administration of retinoids represents an important part of treatment for children suffering from high-risk neuroblastomas, approximately 50% of these patients do not respond to this therapy or develop resistance to retinoids during trea
Externí odkaz:
https://doaj.org/article/19d36be6682b4ff194fe653d7664d815
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 9, p 3157 (2020)
Tyrosine kinase inhibitors (TKIs) are being increasingly used to treat various malignancies. Although they were designed to target aberrant tyrosine kinases, they are also intimately linked with the mechanisms of multidrug resistance (MDR) in cancer
Externí odkaz:
https://doaj.org/article/6b6fff6365fc40ec99b368fa36d98ec0
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0172552 (2017)
Medulloblastoma comprises four main subgroups (WNT, SHH, Group 3 and Group 4) originally defined by transcriptional profiling. In primary medulloblastoma tissues, these groups are thought to be distinguishable using the immunohistochemical detection
Externí odkaz:
https://doaj.org/article/e7481c1b28db40aab3b427b3170f65ce
Autor:
Emília Sousa, Sara Gomes, Liliana Raimundo, Joana Soares, Joana Loureiro, Mariana Leão, Helena Ramos, Madalena Monteiro, Petr Chlapek, Renata Veselská, Agostinho Lemos, Joana Moreira, Madalena Pinto, Lucilia Saraiva
Publikováno v:
Proceedings, Vol 22, Iss 1, p 56 (2019)
In our quest to discover antitumor agents with novel mechanisms of action, our strategyconcerned multiple molecular modifications in a chemical core. [...]
Externí odkaz:
https://doaj.org/article/4953b2f17b704165882766a1789b912b