Zobrazeno 1 - 10
of 197
pro vyhledávání: '"Petr Babula"'
Autor:
Zdeněk Kejík, Jan Hajduch, Nikita Abramenko, Frédéric Vellieux, Kateřina Veselá, Jindřiška Leischner Fialová, Kateřina Petrláková, Kateřina Kučnirová, Robert Kaplánek, Ameneh Tatar, Markéta Skaličková, Michal Masařík, Petr Babula, Petr Dytrych, David Hoskovec, Pavel Martásek, Milan Jakubek
Publikováno v:
Communications Chemistry, Vol 7, Iss 1, Pp 1-39 (2024)
Abstract Mitochondrial dysregulation plays a significant role in the carcinogenesis. On the other hand, its destabilization strongly represses the viability and metastatic potential of cancer cells. Photodynamic and photothermal therapies (PDT and PT
Externí odkaz:
https://doaj.org/article/0019f2607d5e43579b6b7aca24b4ff31
Autor:
Tereza Brogyanyi, Zdeněk Kejík, Kateřina Veselá, Petr Dytrych, David Hoskovec, Michal Masařik, Petr Babula, Robert Kaplánek, Tomáš Přibyl, Jaroslav Zelenka, Tomáš Ruml, Martin Vokurka, Pavel Martásek, Milan Jakubek
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 179, Iss , Pp 117407- (2024)
Mitochondrial autophagy (mitophagy) is very important process for the maintenance of cellular homeostasis, functionality and survival. Its dysregulation is associated with high risk and progression numerous serious diseases (e.g., oncological, neurod
Externí odkaz:
https://doaj.org/article/6d7479d30edb474cbe369d571a257d63
Publikováno v:
European Journal of Cell Biology, Vol 103, Iss 2, Pp 151415- (2024)
The 3-mercaptopyruvate sulfurtransferase (MPST) is a protein persulfidase, occurring mainly in mitochondria. Although function of this protein in cancer cells has been already studied, no clear outcome can be postulated up to now. Therefore, we focus
Externí odkaz:
https://doaj.org/article/29f785892c92490cbac65b50aab37f4c
Autor:
Nikita Abramenko, Fréderic Vellieux, Kateřina Veselá, Zdeněk Kejík, Jan Hajduch, Michal Masařík, Petr Babula, David Hoskovec, Karel Pacák, Pavel Martásek, Karel Smetana, Milan Jakubek
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Immune checkpoints regulate the immune system response. Recent studies suggest that flavonoids, known as phytoestrogens, may inhibit the PD-1/PD-L1 axis. We explored the potential of estrogens and 17 Selective Estrogen Receptor Modulators (S
Externí odkaz:
https://doaj.org/article/031511e97a734e7a80fb86a3fbb5fcab
Autor:
Veronika Liskova, Barbora Chovancova, Kristina Galvankova, Ladislav Klena, Katarina Matyasova, Petr Babula, Marian Grman, Ingeborg Rezuchova, Maria Bartosova, Olga Krizanova
Publikováno v:
Biomolecules, Vol 14, Iss 6, p 651 (2024)
Paclitaxel (PTX) is a chemotherapeutic agent affecting microtubule polymerization. The efficacy of PTX depends on the type of tumor, and its improvement would be beneficial in patients’ treatment. Therefore, we tested the effect of slow sulfide don
Externí odkaz:
https://doaj.org/article/0e31b42b4978400bb463aa7e491cf9bb
Autor:
Robert Kaplánek, Zdeněk Kejík, Jan Hajduch, Kateřina Veselá, Kateřina Kučnirová, Markéta Skaličková, Anna Venhauerová, Božena Hosnedlová, Róbert Hromádka, Petr Dytrych, Petr Novotný, Nikita Abramenko, Veronika Antonyová, David Hoskovec, Petr Babula, Michal Masařík, Pavel Martásek, Milan Jakubek
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 166, Iss , Pp 115324- (2023)
TET proteins (methylcytosine dioxygenases) play an important role in the regulation of gene expression. Dysregulation of their activity is associated with many serious pathogenic states such as oncological diseases. Regulation of their activity by sp
Externí odkaz:
https://doaj.org/article/5c2fac8900f04ce2a9512f02c02393de
Autor:
Veronika Liskova, Barbora Chovancova, Petr Babula, Ingeborg Rezuchova, Kristina Ploth Pavlov, Miroslava Matuskova, Olga Krizanova
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
BackgroundCystathionine β-synthase (CBS), one of three enzymes that endogenously produce hydrogen sulfide, is extensively studied for its relevance in the cells of various tumors. In our previous work, we observed that the immunofluorescence pattern
Externí odkaz:
https://doaj.org/article/e90d9a8d386b450980613bfb48765634
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Wound healing is a very complex process, where variety of different pathways is activated, depending on the phase of healing. Improper or interrupted healing might result in development of chronic wounds. Therefore, novel approaches based on detailed
Externí odkaz:
https://doaj.org/article/0ab592969e3a4418bd92b3f98dfda6ae
Publikováno v:
Plants, Vol 12, Iss 4, p 727 (2023)
Mercury (Hg) content measured in five epiphytic lichen species collected in Slovakia mountain forests ranged from 30 to 100 ng/g DW and was species-specific, decreasing in the order Hypogymnia > Pseudevernia > Usnea > Xanthoria > Evernia prunastri (b
Externí odkaz:
https://doaj.org/article/8357b8e445964fd9b20a23a0290b784a
Autor:
Jan Breza, Andrea Soltysova, Sona Hudecova, Adela Penesova, Ivan Szadvari, Petr Babula, Barbora Chovancova, Lubomira Lencesova, Ondrej Pos, Karol Ondrias, Olga Krizanova
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-8 (2018)
Abstract Background Knowledge about the expression and thus a role of enzymes that produce endogenous H2S - cystathionine-β-synthase, cystathionine γ-lyase and mercaptopyruvate sulfurtransferase - in renal tumors is still controversial. In this stu
Externí odkaz:
https://doaj.org/article/73ffcb530be84679a388e8fd559d9899