Zobrazeno 1 - 10
of 99
pro vyhledávání: '"Petr Dzubak"'
Autor:
Tereza Buchtova, Zdenek Skrott, Katarina Chroma, Jiri Rehulka, Petr Dzubak, Marian Hajduch, David Lukac, Stefanos Arampatzis, Jiri Bartek, Martin Mistrik
Publikováno v:
Molecular Oncology, Vol 16, Iss 7, Pp 1541-1554 (2022)
Disulfiram (DSF), an established alcohol‐aversion drug, is a candidate for repurposing in cancer treatment. DSF’s antitumor activity is supported by preclinical studies, case reports, and small clinical trials; however, ongoing clinical trials of
Externí odkaz:
https://doaj.org/article/3191b1b97405485c86205c2179ad7bf2
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 146, Iss , Pp 112549- (2022)
MAP/microtubule affinity-regulating kinases (MARKs) were recently identified as potential drug targets for Alzheimer's disease (AD) due to their role in pathological hyperphosphorylation of tau protein. Hyperphosphorylated tau has decreased affinity
Externí odkaz:
https://doaj.org/article/c9fca56682b24443bcb0a4de1f2763d8
Autor:
Ondrej Bouska, Hana Jaworek, Vladimira Koudelakova, Katerina Kubanova, Petr Dzubak, Rastislav Slavkovsky, Branislav Siska, Petr Pavlis, Jana Vrbkova, Marian Hajduch
Publikováno v:
Viruses, Vol 14, Iss 12, p 2829 (2022)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused considerable disruption worldwide. For efficient SARS-CoV-2 detection, new methods of rapid, non-invasive sampling are needed. This study aimed to investigate the stability of SA
Externí odkaz:
https://doaj.org/article/c61b837781b3486bb14ac66244978a4e
Publikováno v:
HemaSphere, Vol 6, Pp 2025-2026 (2022)
Externí odkaz:
https://doaj.org/article/df81d3b45a84429ea6dc9fb197d07815
Autor:
Radu A. Paun, Daciana C. Dumut, Amanda Centorame, Thusanth Thuraisingam, Marian Hajduch, Martin Mistrik, Petr Dzubak, Juan B. De Sanctis, Danuta Radzioch, Maryam Tabrizian
Publikováno v:
Pharmaceutics, Vol 14, Iss 3, p 640 (2022)
The metal complex copper diethyldithiocarbamate (CuET) induces cancer cell death by inhibiting protein degradation and induces proteotoxic stress, making CuET a promising cancer therapeutic. However, no clinical formulation of CuET exists to date as
Externí odkaz:
https://doaj.org/article/9a7a1378cb3244ff93fef87229b73e23
Publikováno v:
Česká gynekologie. 88:4-12
Cervical mucus is a viscous fluid functioning as a cervix plug. Products of the endometrial and cervical glands can be detected in the cervical mucus. Cervical mucus is further enriched with transudate originating from the fallopian tubes and protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97bd52eab874f954c194f6620c756aec
https://doi.org/10.48095/cccg20234
https://doi.org/10.48095/cccg20234
Autor:
Martin Hruby, Khushboo Agrawal, Olivia Policianova, Jiri Brus, Jan Skopal, Pavel Svec, Miroslav Otmar, Petr Dzubak, Petr Stepanek, Marian Hajduch
Publikováno v:
Biomedical Papers, Vol 160, Iss 2, Pp 222-230 (2016)
Background: The archetypal DNA methyltransferase inhibitors, 5-azacytidine (AZA) and 5-aza-2'-deoxycytidine (DAC) are potent antineoplastic agents used in the treatment of mainly, blood malignancies. However, the administration of these drugs is conf
Externí odkaz:
https://doaj.org/article/cbba99dfdc65480fb1ebb674d8b9a70e
Autor:
Matthew Lacey, Jiri Bartek, Antonino Giulio Giannone, Anton B. Tonchev, Sean P. Curran, Tommaso Mazza, Kristina Kovacovicova, Daniela Cabibi, Oriana Lo Re, Sebastiano Giallongo, Tommaso Biagini, Martin Mistrik, Jan Frohlich, Martin Ivanov, Sona Gurska, Manlio Vinciguerra, James D. Nhan, Petr Dzubak, Marco Raffaele, Vincenzo Micale, Marian Hajduch
Publikováno v:
GeroScience
Accumulation of senescent cells may drive age-associated alterations and pathologies. Senolytics are promising therapeutics that can preferentially eliminate senescent cells. Here, we performed a high-throughput automatized screening (HTS) of the com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::354ad9a69c654e9e3fc8dc1ee2516143
https://doi.org/10.1007/s11357-021-00487-y
https://doi.org/10.1007/s11357-021-00487-y
Autor:
Erika Kužmová, Vishwas Joshi, Jaroslav Kozák, Lukáš Severa, Lucie Bednarova, Yevgen Yurenko, Juraj Dobiaš, Adam Pecina, Cemal Köprülüoğlu, Petr Jurečka, Martin Lepšík, Ivana Cisarova, Radek Pohl, Piotr Jurkiewicz, Marek Cebecauer, Radek Trojanec, Petr Dzubak, Marian Hajduch, Libuše Lizcová, Karla Svobodová, Zuzana Zemanová, Filip Teplý, Paul E. Reyes-Gutiérrez, Zbigniew Zawada
DNA-binding fluorescent probes are useful tools in cell biology for various applications enabling visualisation and quantification of DNA. Herein, we report on HeliDye1, a novel cationic helicene-like DNA probe, and its versatile usability. HeliDye1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37356cc826c2ae51a273ebd8939f56e2
https://doi.org/10.21203/rs.3.rs-737372/v2
https://doi.org/10.21203/rs.3.rs-737372/v2
Autor:
Veronika Sidova, Pavel Zoufaly, Jan Pokorny, Petr Dzubak, Marian Hajduch, Igor Popa, Milan Urban
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0171621 (2017)
In this work, we describe synthesis of conjugates of betulinic acid with substituted triazoles prepared via Huisgen 1,3-cycloaddition. All compounds contain free 28-COOH group. Allylic bromination of protected betulinic acid by NBS gave corresponding
Externí odkaz:
https://doaj.org/article/bbf991cc9abd49d2a59f43911c64a602