CAR T cells with dual targeting of CD19 and CD22 in pediatric and young adult patients with relapsed or refractory B cell acute lymphoblastic leukemia: a phase 1 trial.

Autor: Cordoba S; Autolus PLC, London, UK., Onuoha S; Autolus PLC, London, UK., Thomas S; Autolus PLC, London, UK., Pignataro DS; Autolus PLC, London, UK., Hough R; Department of Haematology, University College London Hospitals NHS Trust, London, UK., Ghorashian S; Departments of Bone Marrow Transplant and Haematology, Great Ormond Street Hospital for Children, London, UK., Vora A; Departments of Bone Marrow Transplant and Haematology, Great Ormond Street Hospital for Children, London, UK., Bonney D; Department of Blood and Marrow Transplant, Royal Manchester Children's Hospital, Manchester, UK., Veys P; Departments of Bone Marrow Transplant and Haematology, Great Ormond Street Hospital for Children, London, UK., Rao K; Departments of Bone Marrow Transplant and Haematology, Great Ormond Street Hospital for Children, London, UK., Lucchini G; Departments of Bone Marrow Transplant and Haematology, Great Ormond Street Hospital for Children, London, UK., Chiesa R; Departments of Bone Marrow Transplant and Haematology, Great Ormond Street Hospital for Children, London, UK., Chu J; Departments of Bone Marrow Transplant and Haematology, Great Ormond Street Hospital for Children, London, UK., Clark L; Autolus PLC, London, UK., Fung MM; Autolus PLC, London, UK., Smith K; Autolus PLC, London, UK., Peticone C; Autolus PLC, London, UK., Al-Hajj M; Autolus PLC, London, UK., Baldan V; Autolus PLC, London, UK., Ferrari M; Autolus PLC, London, UK., Srivastava S; Autolus PLC, London, UK., Jha R; Autolus PLC, London, UK., Arce Vargas F; Autolus PLC, London, UK., Duffy K; Autolus PLC, London, UK., Day W; Autolus PLC, London, UK., Virgo P; Department of Immunology and Immunogenetics, North Bristol NHS Trust, Bristol, UK., Wheeler L; Department of Immunology and Immunogenetics, North Bristol NHS Trust, Bristol, UK., Hancock J; Bristol Genetics Laboratory, North Bristol NHS Trust, Bristol, UK., Farzaneh F; Rayne Institute, Kings College London, London, UK., Domning S; Rayne Institute, Kings College London, London, UK., Zhang Y; Autolus PLC, London, UK., Khokhar NZ; Autolus PLC, London, UK., Peddareddigari VGR; Autolus PLC, London, UK., Wynn R; Department of Blood and Marrow Transplant, Royal Manchester Children's Hospital, Manchester, UK., Pule M; Autolus PLC, London, UK. m.pule@autolus.com.; Cancer Institute, University College London, London, UK. m.pule@autolus.com., Amrolia PJ; Departments of Bone Marrow Transplant and Haematology, Great Ormond Street Hospital for Children, London, UK.

Publikováno v: Nature medicine [Nat Med] 2021 Oct; Vol. 27 (10), pp. 1797-1805. Date of Electronic Publication: 2021 Oct 12.

Enriching leukapheresis improves T cell activation and transduction efficiency during CAR T processing.

Autor: Noaks E; Department of Biochemical Engineering, University College London, Bernard Katz Building, Gower Street, London WC1E 6BT, UK., Peticone C; Autolus Therapeutics Ltd., The Mediaworks, 191 Wood Lane, White City, London W12 7FP, UK., Kotsopoulou E; Autolus Therapeutics Ltd., The Mediaworks, 191 Wood Lane, White City, London W12 7FP, UK., Bracewell DG; Department of Biochemical Engineering, University College London, Bernard Katz Building, Gower Street, London WC1E 6BT, UK.

Publikováno v: Molecular therapy. Methods & clinical development [Mol Ther Methods Clin Dev] 2021 Feb 06; Vol. 20, pp. 675-687. Date of Electronic Publication: 2021 Feb 06 (Print Publication: 2021).

Characterisation of osteogenic and vascular responses of hMSCs to Ti-Co doped phosphate glass microspheres using a microfluidic perfusion platform.

Autor: Peticone C; Department of Biochemical Engineering, University College London, London, UK., Thompson DS; Department of Biochemical Engineering, University College London, London, UK., Dimov N; Centre for Engineering Research, University of Hertfordshire, Hatfield, Hertfordshire, UK., Jevans B; Great Ormond Street Institute of Child Health, University College London, London, UK., Glass N; Australian Institute for Bioengineering and Nanotechnology, University of Queensland, St. Lucia, Brisbane, Australia., Micheletti M; Department of Biochemical Engineering, University College London, London, UK., Knowles JC; Division of Biomaterials and Tissue Engineering, University College London Eastman Dental Institute, London, UK.; The Discoveries Centre for Regenerative and Precision Medicine, UCL Campus, London, UK.; Department of Nanobiomedical Science & BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan, Republic of Korea.; UCL Eastman-Korea Dental Medicine Innovation Centre, Dankook University, Cheonan, Republic of Korea.; Institute for Tissue Regeneration Engineering, Dankook University, Cheonan, Republic of Korea., Kim HW; Department of Nanobiomedical Science & BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan, Republic of Korea.; UCL Eastman-Korea Dental Medicine Innovation Centre, Dankook University, Cheonan, Republic of Korea.; Institute for Tissue Regeneration Engineering, Dankook University, Cheonan, Republic of Korea., Cooper-White JJ; Australian Institute for Bioengineering and Nanotechnology, University of Queensland, St. Lucia, Brisbane, Australia.; School of Chemical Engineering, University of Queensland, St. Lucia, Brisbane, Australia., Wall IB; Department of Biochemical Engineering, University College London, London, UK.; Institute for Tissue Regeneration Engineering, Dankook University, Cheonan, Republic of Korea.; Aston Medical Research Institute and School of Life and Health Sciences, Aston University, Birmingham, UK.

Publikováno v: Journal of tissue engineering [J Tissue Eng] 2020 Oct 24; Vol. 11, pp. 2041731420954712. Date of Electronic Publication: 2020 Oct 24 (Print Publication: 2020).

Novel strategies to assess cytokine release mediated by chimeric antigen receptor T cells based on the adverse outcome pathway concept.

Autor: Alb, Miriam¹ (AUTHOR) alb_m@ukw.de, Reiche, Kristin² (AUTHOR), Rade, Michael² (AUTHOR), Sewald, Katherina³ (AUTHOR), Loskill, Peter^4,5,6 (AUTHOR), Cipriano, Madalena^4,5 (AUTHOR), Maulana, Tengku Ibrahim^4,5 (AUTHOR), van der Meer, Andries D.⁷ (AUTHOR), Weener, Huub J.⁷ (AUTHOR), Clerbaux, Laure-Alix⁸ (AUTHOR), Fogal, Birgit⁹ (AUTHOR), Patel, Nirav¹⁰ (AUTHOR), Adkins, Karissa¹⁰ (AUTHOR), Lund, Emma¹¹ (AUTHOR), Perkins, Ethan¹¹ (AUTHOR), Cooper, Christopher¹¹ (AUTHOR), van den Brulle, Jan¹² (AUTHOR), Morgan, Hannah¹³ (AUTHOR), Rubic-Schneider, Tina¹³ (AUTHOR), Ling, Hui¹⁴ (AUTHOR)

Publikováno v: Journal of Immunotoxicology. 2024 Suppl 1, Vol. 21, pS13-S28. 16p.

Assessing behaviour of osteoblastic cells in dynamic culture conditions using titanium-doped phosphate glass microcarriers.

Autor: De Silva Thompson D; Department of Biochemical Engineering, University College London, London, UK., Peticone C; Department of Biochemical Engineering, University College London, London, UK., Burova I; Department of Mechanical Engineering, University College London, London, UK., Shipley RJ; Department of Mechanical Engineering, University College London, London, UK., Knowles JC; Division of Biomaterials and Tissue Engineering, Eastman Dental Institute, University College London, London, UK.; The Discoveries Centre for Regenerative and Precision Medicine, University College London, London, UK.; Department of Nanobiomedical Science and BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan, Republic of Korea.; UCL Eastman-Korea Dental Medicine Innovation Centre, Dankook University, Cheonan, Republic of Korea., Kim HW; Department of Nanobiomedical Science and BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan, Republic of Korea.; UCL Eastman-Korea Dental Medicine Innovation Centre, Dankook University, Cheonan, Republic of Korea.; Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan, Republic of Korea., Micheletti M; Department of Biochemical Engineering, University College London, London, UK., Wall IB; Department of Biochemical Engineering, University College London, London, UK.; Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan, Republic of Korea.; Aston Medical Research Institute and School of Life & Health Sciences, Aston University, Birmingham, UK.

Publikováno v: Journal of tissue engineering [J Tissue Eng] 2019 Feb 08; Vol. 10, pp. 2041731419825772. Date of Electronic Publication: 2019 Feb 08 (Print Publication: 2019).