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Target enzyme mutations are the molecular basis for resistance towards pharmacological inhibition of nicotinamide phosphoribosyltransferase

Autor: Christensen Mette K, Imai Shin-Ichiro, Yoshino Jun, Kiess Wieland, Garten Antje, Petersen Jakob G, Olesen Uffe H, Fristrup Peter, Thougaard Annemette V, Björkling Fredrik, Jensen Peter B, Nielsen Søren J, Sehested Maxwell

Publikováno v: BMC Cancer, Vol 10, Iss 1, p 677 (2010)

Abstract Background Inhibitors of nicotinamide phosphoribosyltransferase (NAMPT) are promising cancer drugs currently in clinical trials in oncology, including APO866, CHS-828 and the CHS-828 prodrug EB1627/GMX1777, but cancer cell resistance to thes

Externí odkaz: https://doaj.org/article/fa4b3650926e431fa6039c81f84b1fdf

Restrictive fluids versus standard care in adults with sepsis in the emergency department (REFACED): A multicenter, randomized feasibility trial.

Autor: Jessen MK; Department of Clinical Medicine, Research Center for Emergency Medicine, Aarhus University and Aarhus University Hospital, Aarhus, Denmark.; Department of Emergency Medicine, Aarhus University Hospital, Aarhus, Denmark., Andersen LW; Department of Clinical Medicine, Research Center for Emergency Medicine, Aarhus University and Aarhus University Hospital, Aarhus, Denmark.; Department of Anesthesiology and Intensive Care, Aarhus University Hospital, Aarhus, Denmark.; Prehospital Emergency Medical Services, Central Denmark Region, Aarhus, Denmark., Thomsen MH; Department of Clinical Medicine, Research Center for Emergency Medicine, Aarhus University and Aarhus University Hospital, Aarhus, Denmark.; Department of Emergency Medicine, Aarhus University Hospital, Aarhus, Denmark., Kristensen P; Department of Emergency Medicine, Regional Hospital Viborg, Viborg, Denmark., Hayeri W; Department of Emergency Medicine, Regional Hospital Randers, Randers, Denmark., Hassel RE; Department of Emergency Medicine, Aarhus University Hospital, Aarhus, Denmark., Messerschmidt TG; Department of Emergency Medicine, Regional Hospital Randers, Randers, Denmark., Sølling CG; Department of Intensive Care, Regional Hospital Viborg, Viborg, Denmark., Perner A; Department of Intensive Care, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Petersen JAK; Department of Anesthesiology and Intensive Care, Aarhus University Hospital, Aarhus, Denmark., Kirkegaard H; Department of Clinical Medicine, Research Center for Emergency Medicine, Aarhus University and Aarhus University Hospital, Aarhus, Denmark.; Department of Emergency Medicine, Aarhus University Hospital, Aarhus, Denmark.; Prehospital Emergency Medical Services, Central Denmark Region, Aarhus, Denmark.

Publikováno v: Academic emergency medicine : official journal of the Society for Academic Emergency Medicine [Acad Emerg Med] 2022 Oct; Vol. 29 (10), pp. 1172-1184. Date of Electronic Publication: 2022 Aug 05.