Quantification of Cre-mediated recombination by a novel strategy reveals a stable extra-chromosomal deletion-circle in mice

Autor: Breuning Martijn H, Lantinga-van Leeuwen Irma S, Roelfsema Jeroen H, Leonhard Wouter N, Peters Dorien JM

Publikováno v: BMC Biotechnology, Vol 8, Iss 1, p 18 (2008)

Abstract Background Inducible conditional knockout animals are widely used to get insight in the function of genes and the pathogenesis of human diseases. These models frequently rely on Cre-mediated recombination of sequences flanked by Lox-P sites.

Externí odkaz: https://doaj.org/article/cfcae8d357c1450b968d8ca4cfeec1e3

Four‐jointed knock‐out delays renal failure in an ADPKD model with kidney injury.

Autor: Formica, Chiara, Happé, Hester, Veraar, Kimberley AM, Vortkamp, Andrea, Scharpfenecker, Marion, McNeill, Helen, Peters, Dorien JM

Publikováno v: Journal of Pathology; Sep2019, Vol. 249 Issue 1, p114-125, 12p

Altered Hippo signalling in polycystic kidney disease.

Autor: Happé, Hester, van der Wal, Annemieke M, Leonhard, Wouter N, Kunnen, Steven J, Breuning, Martijn H, de Heer, Emile, Peters, Dorien JM

Publikováno v: Journal of Pathology; May2011, Vol. 224 Issue 1, p133-142, 10p

Genes homologous to the autosomal dominant polycystic kidney disease genes (PKD1 and PKD2).

Autor: Veldhuisen, Barbera, Spruit, Lia, Dauwerse, Hans G, Breuning, Martijn H, Peters, Dorien JM

Publikováno v: European Journal of Human Genetics; Dec99, Vol. 7 Issue 8, p860, 13p

Modelling TFE renal cell carcinoma in mice reveals a critical role of WNT signaling.

Autor: Calcagnì A; Telethon Institute of Genetics and Medicine, TIGEM, Pozzuoli, Naples, Italy., Kors L; Telethon Institute of Genetics and Medicine, TIGEM, Pozzuoli, Naples, Italy.; Department of Pathology, Academical Medical Center, Amsterdam, The Netherlands., Verschuren E; Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.; Department of Human Genetics, Leiden University Medical Center, Leiden, Netherlands., De Cegli R; Telethon Institute of Genetics and Medicine, TIGEM, Pozzuoli, Naples, Italy., Zampelli N; Telethon Institute of Genetics and Medicine, TIGEM, Pozzuoli, Naples, Italy., Nusco E; Telethon Institute of Genetics and Medicine, TIGEM, Pozzuoli, Naples, Italy., Confalonieri S; Molecular Medicine Program, European Institute of Oncology, Milan, Italy.; IFOM, The FIRC Institute for Molecular Oncology Foundation, Milan, Italy., Bertalot G; Molecular Medicine Program, European Institute of Oncology, Milan, Italy., Pece S; Molecular Medicine Program, European Institute of Oncology, Milan, Italy.; Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy., Settembre C; Telethon Institute of Genetics and Medicine, TIGEM, Pozzuoli, Naples, Italy.; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.; Jan and Dan Duncan Neurological Research Institute, Texas Children Hospital, Houston, United States.; Medical Genetics, Federico II University, Naples, Italy.; Medical Genetics, Department of Medical and Translational Sciences, Federico II University, Naples, Italy., Malouf GG; Department of Medical Oncology Groupe Hospitalier Pitie-Salpetriere, University Paris 6, Paris, France.; Assistance Publique Hopitaux de Paris, University Paris 6, Paris, France.; Faculty of Medicine Pierre et Marie Curie, University Paris 6, Paris, France.; Institut Universitaire de Cancerologie GRC5, University Paris 6, Paris, France., Leemans JC; Department of Pathology, Academical Medical Center, Amsterdam, The Netherlands., de Heer E; Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands., Salvatore M; IRCCS-SDN, Naples, Italy., Peters DJ; Department of Human Genetics, Leiden University Medical Center, Leiden, Netherlands., Di Fiore PP; Molecular Medicine Program, European Institute of Oncology, Milan, Italy.; IFOM, The FIRC Institute for Molecular Oncology Foundation, Milan, Italy.; Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy., Ballabio A; Telethon Institute of Genetics and Medicine, TIGEM, Pozzuoli, Naples, Italy.; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.; Jan and Dan Duncan Neurological Research Institute, Texas Children Hospital, Houston, United States.; Medical Genetics, Federico II University, Naples, Italy.; Medical Genetics, Department of Medical and Translational Sciences, Federico II University, Naples, Italy.

Publikováno v: ELife [Elife] 2016 Sep 26; Vol. 5. Date of Electronic Publication: 2016 Sep 26.