Zobrazeno 1 - 10 of 60 pro vyhledávání: '"Peters, Thies"'
1
Interference of n-(1-[4-(4-fluorophenoxy) butyl]-piperidinyl)-n-methyl-2-benzothiazolamine with na+/h+ exchange and na+/ca2+ exchange in purified cardiac sarcolemmal membranes
Autor: SCHEUFLER, E, HEERS, C, WILFFERT, B, Peters, Thies, PIERCE, GN
Publikováno v: Arzneimittel-Forschung/drug research, 43-2(11), 1145-1147
The effect of R 56865 (N-[1-[4-(4-fluorophenoxy)butyl]-piperidinyl]-N-methyl-2-benzothiazolamine, CAS 104606-13-5) on Na+/H+ exchange and Na+/Ca2+ exchange was studied in isolated cardiac sarcolemmal vesicles. R 56865 inhibited Na+/H+ exchange with a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::cc66afe7c016e2adcfc63dc532bdb80e
https://research.rug.nl/en/publications/53541455-9b57-476a-b7f3-4996e6e41589
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2
Interference of N-(1-[4-(4-fluophenoxy)butyl]-piperidinyl)-N-methyl-2-benzothiazolamin e with Na+/H+exchange and Na+/Ca2+exchange in purified cardiac sarcolemmal membranes
Autor: Scheufler, E., Heers, C., Wilffert, B., Peters, Thies, Pierce, G.N.
Publikováno v: Arzneimittel-Forschung-Drug research, 43(11), 1145-1147
The effect of R 56865 (N-[1-[4-(4-fluorophenoxy) butyl]-piperidinyl]-N-methyl-2-benzothiazolamine, CAS 104606-13-5) on Na+/H+exchange and Na+/Ca2+exchange was studied in isolated cardiac sarcolemmal vesicles. R 56865 inhibited Na+/H+exchange with an
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::c5e483aab23be59aba47d9813a918b0c
https://research.rug.nl/en/publications/b2580f09-5dbe-4597-86ef-2ce0a3d7894b
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3
In-vivo skin pharmacokinetics of liarozole - percutaneous-absorption studies with different formulations of cyclodextrin derivatives in rats
Autor: VOLLMER, U, MULLER, BW, MESENS, J, WILFFERT, B, Peters, Thies
Publikováno v: International Journal of Pharmaceutics, 99(1), 51-58. Elsevier Bedrijfsinformatie b.v.
The aim of the study was to evaluate whether 2-hydroxypropyl-beta-cyclodextrin (HPbetaCD) can be used as transdermal absorption enhancer for liarozole. Therefore, we used an in vivo model where transdermal drug absorption in rats can be studied under
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::2b676c1083583b9d1a1b1f8dc3a1e883
https://research.rug.nl/en/publications/8c3feee7-d7d4-414b-aee3-17ba24b1bf43
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4
An improved model for studies on transdermal drug absorption invivo in rats
Autor: VOLLMER, U, MULLER, BW, WILFFERT, B, Peters, Thies
Publikováno v: Journal of Pharmacy and Pharmacology, 45(4), 242-245
In rats, transdermal drug absorption can be studied under physiological conditions by cannulating the peripheral skin vein, draining the area of the skin which is used for drug application, and collecting the blood. This method leads to decreased blo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::b8910ae727f99d98984dde12ef3e4233
https://research.rug.nl/en/publications/002be4ad-bf34-4a88-b40a-cb932d81f3c4
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5
Cardiac effects of r-79595 and its isomers (r-80122 and r-80123) in an acute heart-failure model - a new class of cardiotonic agents with highly selective phosphodiesterase-iii inhibitory properties
Autor: SCHNEIDER, J, BECK, E, HEERS, C, CONRAD, C, DECOURCELLES, DD, WILFFERT, B, Peters, Thies
Publikováno v: Naunyn-Schmiedebergs Archives of Pharmacology, 346(5), 563-572. SPRINGER
R 79595 (N-cyclohexyl-N-methyl-2-[[[phenyl (1,2,3,5-tetrahydro-2 oxoimidazo [2,1-b]-quinazolin-7-yl) methylene] amin] oxy] acetamide) and its isomers represent a novel class of compounds with phosphodiesterase (PDE) inhibitory and cardiotonic (positi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::495ecb503cd920f53e19933c7e457ffd
https://research.rug.nl/en/publications/135a04b5-078c-4e23-a1d0-0a5a87476958
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7
Veratridine activates a silent sodium-channel in rat isolated aorta
Autor: WERMELSKIRCHEN, D, WILFFERT, B, NEBEL, U, LEIDIG, A, WIRTH, A, Peters, Thies
Publikováno v: European Journal of Pharmacology, 219(2), 253-259. ELSEVIER SCIENCE BV
To investigate the existence of silent Na+ channels, isolated rat aorta was treated with veratridine (0.1 mM) and the resulting Ca2+ uptake was determined. After 30-min incubation the total tissue uptake of Ca2+ and Ca2+ uptake increased from 2.325 +
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::97c03933e2981b83da4cf184c0500f23
https://research.rug.nl/en/publications/4e5a6485-5a53-4834-9f74-2f9468c32ff0
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9
Flunarizine and r-56865 suppress veratridine-induced increase in oxygen-consumption and uptake of ca-45(2+) in rat cortical synaptosomes
Autor: WERMELSKIRCHEN, D, GLEITZ, J, URENJAK, J, WILFFERT, B, TEGTMEIER, F, Peters, Thies
Publikováno v: Neuropharmacology, 31(3), 235-241. PERGAMON-ELSEVIER SCIENCE LTD
The effect of the anti-ischemic compounds flunarizine and R 56865 on the veratridine-induced uptake of Ca2+ and Na+ was observed in cortical synaptosomes in the rat. The veratridine-induced uptake of Na+ and Ca2+ was determined by means of a measurem
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::fa2214b101973ab37a9b2416909bad09
https://research.rug.nl/en/publications/21c940dc-305b-4742-9461-0380f43c4e95
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10
Invitro pharmacology of r-80122, a novel phosphodiesterase inhibitor
Autor: WILHELM, D, WILFFERT, B, JANSSENS, WJ, LEIDIG, A, MEUTER, C, EBBERT, M, Peters, Thies
Publikováno v: Journal of Cardiovascular Pharmacology, 20(5), 705-714
The cardiac in vitro effects of R 80122, a novel phosphodiesterase (PDE) inhibitor, were investigated and compared with those of the reference compound milrinone and of the calcium-sensitizer adibendan. In guinea pig left atria, both milrinone and R
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::a2d8e04fe60d4b73a12563a9853d7a57
https://research.rug.nl/en/publications/1d0beec4-d8e4-4d57-8965-a877c3595ea5
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