Blood stem cell-forming haemogenic endothelium in zebrafish derives from arterial endothelium

Autor: Bonkhofer, F, Rispoli, R, Pinheiro, P, Krecsmarik, M, Schneider-Swales, J, Tsang, I, De Bruijn, M, Monteiro, R, Peterkin, T, Patient, R

Publikováno v: Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)

Haematopoietic stem cells are generated from the haemogenic endothelium (HE) located in the floor of the dorsal aorta (DA). Despite being integral to arteries, it is controversial whether HE and arterial endothelium share a common lineage. Here, we p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::5706a77e83adcd8df315c69e44056e3a
https://doi.org/10.1038/s41467-019-11423-2

Cardiopoietic Factors: Extracellular Signals for Cardiac Lineage Commitment

Autor: Noseda, M, Peterkin, T, Simões, FC, Patient, R, Schneider, MD

Publikováno v: Circulation Research; Vol 108
Circulation Research

Cardiac muscle creation during embryogenesis requires extracellular instructive signals that are regulated precisely in time and space, intersecting with intracellular genetic programs that confer or fashion the ability of the cells to respond. Unmas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4b8a7d758c6874981914a13e4110f1a

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Transforming Growth Factor β Drives Hemogenic Endothelium Programming and the Transition to Hematopoietic Stem Cells.

Autor: Monteiro R; Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK; BHF Centre of Research Excellence, Oxford, UK. Electronic address: rui.monteiro@imm.ox.ac.uk., Pinheiro P; Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK., Joseph N; Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK., Peterkin T; Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK., Koth J; Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK., Repapi E; Computational Biology Research Group, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK., Bonkhofer F; Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK., Kirmizitas A; Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK., Patient R; Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK; BHF Centre of Research Excellence, Oxford, UK. Electronic address: roger.patient@imm.ox.ac.uk.

Publikováno v: Developmental cell [Dev Cell] 2016 Aug 22; Vol. 38 (4), pp. 358-70. Date of Electronic Publication: 2016 Aug 04.

FGF signalling restricts haematopoietic stem cell specification via modulation of the BMP pathway.

Autor: Pouget C; 1] Department of Cellular and Molecular Medicine, Section of Cell and Developmental Biology, University of California, La Jolla, San Diego, California 92093, USA [2] MRC Molecular Hematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX1 9DS, UK., Peterkin T; MRC Molecular Hematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX1 9DS, UK., Simões FC; MRC Molecular Hematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX1 9DS, UK., Lee Y; Department of Cellular and Molecular Medicine, Section of Cell and Developmental Biology, University of California, La Jolla, San Diego, California 92093, USA., Traver D; Department of Cellular and Molecular Medicine, Section of Cell and Developmental Biology, University of California, La Jolla, San Diego, California 92093, USA., Patient R; MRC Molecular Hematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX1 9DS, UK.

Publikováno v: Nature communications [Nat Commun] 2014 Nov 27; Vol. 5, pp. 5588. Date of Electronic Publication: 2014 Nov 27.