Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Peteris Prusis"'
Autor:
Aleksejs Kontijevskis, Peteris Prusis, Ramona Petrovska, Sviatlana Yahorava, Felikss Mutulis, Ilze Mutule, Jan Komorowski, Jarl E S Wikberg
Publikováno v:
PLoS Computational Biology, Vol 3, Iss 3, p e48 (2007)
Retroviruses affect a large number of species, from fish and birds to mammals and humans, with global socioeconomic negative impacts. Here the authors report and experimentally validate a novel approach for the analysis of the molecular networks that
Externí odkaz:
https://doaj.org/article/18066dc6932c470e83555e01188865cd
Autor:
Andreas Bender, Peteris Prusis, Qurrat Ul Ain, Gerd Wohlfahrt, Helena Henno, Lars-Olof Pietilä, Julian E. Fuchs, Vigneshwari Subramanian
Publikováno v:
MedChemComm. 8:1037-1045
The high similarity between certain sub-pockets of serine proteases may lead to low selectivity of protease inhibitors. Therefore the application of proteochemometrics (PCM), which quantifies the relationship between protein/ligand descriptors and af
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::547b8d3f8bd052f76d87cbd3b6e707d9
https://doi.org/10.1039/c6md00701e
https://doi.org/10.1039/c6md00701e
Autor:
Marta Olszak-Płachta, Mateusz Nowak, Hugh Chapman, Magdalena Sieprawska-Lupa, Raymond Horvath, Klaudia Stefańska, Maciej Mikulski, Marcin Król, Katja Kuokkanen, Michal Galezowski, Mariusz Galek, Niina Jalava, Justyna Adamczyk, Joanna Szeremeta-Spisak, Ullamari Pesonen, Josef Messinger, Harri Salo, Radosław Obuchowicz, Charles-Henry Fabritius, Anna Buda, Peteris Prusis, Timo Korjamo
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:2610-2615
A series of 1-Sulfonyl-6-Piperazinyl-7-Azaindoles, showing strong antagonistic activity to 5-HT6 receptor (5-HT6R) was synthesized and characterized. The series was optimized to reduce activity on D2 receptor. Based on the selectivity against this of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d0e7ddf2aebc8b11e2dc823531d7081
https://doi.org/10.1016/j.bmcl.2016.04.024
https://doi.org/10.1016/j.bmcl.2016.04.024
Publikováno v:
MedChemComm. 7:1007-1015
Proteochemometrics, a method that simultaneously uses protein and ligand description, was used to model the target-ligand interaction space of 95 kinases and 1572 inhibitors. To build models, we applied 3-dimensional field-based description of the re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eacef3be7c090de37939c8d2e26aee4
https://doi.org/10.1039/c5md00556f
https://doi.org/10.1039/c5md00556f
Publikováno v:
Journal of Chemical Information and Modeling. 53:3021-3030
Achieving selectivity for small organic molecules toward biological targets is a main focus of drug discovery but has been proven difficult, for example, for kinases because of the high similarity of their ATP binding pockets. To support the design o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ca99ea40223e164a36287bf38afaaa0
https://doi.org/10.1021/ci400369z
https://doi.org/10.1021/ci400369z
Autor:
Peteris Prusis, Lovisa Afzelius
Publikováno v:
QSAR & Combinatorial Science. 28:865-868
Metabolism plays a significant role in failure of drugs to carry out their intended action in the body. Drugs and other xenobiotics in the body are mainly biotransformed through oxidation reactions catalyzed by cytochrome P450 enzymes, in particular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f45d008c7de5335a098756b2593888b
https://doi.org/10.1002/qsar.200810182
https://doi.org/10.1002/qsar.200810182
Publikováno v:
Journal of Peptide Science. 14:786-796
We demonstrate the use of statistical molecular design (SMD) in the selection of peptide libraries aimed to systematically investigate antigen-antibody binding spaces. Earlier, we derived two novel antibodies by mutating the complementarity-determini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5c4d8e142140a47bf57fec449f06129
https://doi.org/10.1002/psc.999
https://doi.org/10.1002/psc.999
Publikováno v:
Journal of Molecular Recognition. 20:97-102
The aim of this study was to develop predictive quantitative structure-activity relationship (QSAR) modeling for antibody-peptide interactions. A small single chain antibody library was designed and manufactured around the murine anti-p24 (HIV-1) mon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::545114a49ec404e8d6ee653815b9aeb2
https://doi.org/10.1002/jmr.817
https://doi.org/10.1002/jmr.817
Autor:
Peteris Prusis, Pornwaratt Niyomrattanakit, Jarl E. S. Wikberg, Gerd Katzenmeier, Ilze Mutule, Sviatlana Yahorava, Felikss Mutulis, Ramona Petrovska
Publikováno v:
Biochemical Journal. 397:203-211
The NS3 (dengue virus non-structural protein 3) serine protease of dengue virus is an essential component for virus maturation, thus representing an attractive target for the development of antiviral drugs directed at the inhibition of polyprotein pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1ab2c1b69745dffdd6748d1c6e30fe8
https://doi.org/10.1042/bj20051767
https://doi.org/10.1042/bj20051767
Publikováno v:
Bioinformatics. 21:4289-4296
Motivation: Proteochemometrics is a novel technology for the analysis of interactions of series of proteins with series of ligands. We have here customized it for analysis of large datasets and evaluated it for the modeling of the interaction of psyc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e326cd5e9f09736b9b6391ccb8a98ba8
https://doi.org/10.1093/bioinformatics/bti703
https://doi.org/10.1093/bioinformatics/bti703