Decoupling the Functional Pleiotropy of Stem Cell Factor by Tuning c-Kit Signaling

Autor: Jacob Piehler, Philipp Starkl, Matthew Tiffany, Aaron M. Ring, Stephan Wilmes, Milica Gakovic, Jonathan T. Sockolosky, Stephen J. Galli, K. Christopher Garcia, Akanksha Chhabra, Hye-Sook Kwon, Irving L. Weissman, Chia Chi Ho, Peter-John Schnorr, Judith A. Shizuru, Ignacio Moraga, Tom S. Wehrman, Riccardo Sibilano, Nicolas Gaudenzio

Publikováno v: Cell
Cell, Elsevier, 2017, 168 (6), pp.1041-1052.e18. ⟨10.1016/j.cell.2017.02.011⟩
Cell, 2017, 168 (6), pp.1041-1052.e18. ⟨10.1016/j.cell.2017.02.011⟩

International audience; Most secreted growth factors and cytokines are functionally pleiotropic because their receptors are expressed on diverse cell types. While important for normal mammalian physiology, pleiotropy limits the efficacy of cytokines

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50a1081d8f227b99929621a47f8faaa4
https://hal-univ-tlse3.archives-ouvertes.fr/hal-03375039