Intranasal delivery of Salmonella OMVs decorated with Chlamydia trachomatis antigens induces specific local and systemic immune responses

Autor: Dung T. Huynh, Emanuele Nolfi, Lobna Medfai, Peter van Ulsen, Wouter S. P. Jong, Alice J. A. M. Sijts, Joen Luirink

Publikováno v: Human Vaccines & Immunotherapeutics, Vol 20, Iss 1 (2024)

ABSTRACTChlamydia trachomatis is an obligate intracellular pathogen responsible for the most prevalent bacterial sexually transmitted disease globally. The high prevalence of chlamydial infections underscores the urgent need for licensed and effectiv

Externí odkaz: https://doaj.org/article/2716bdd255c7460dada3b26d8b187d92

Heterologous Display of Chlamydia trachomatis PmpD Passenger at the Surface of Salmonella OMVs

Autor: Dung T. Huynh, Wouter S. P. Jong, Manon A. H. Oudejans, H. Bart van den Berg van Saparoea, Joen Luirink, Peter van Ulsen

Publikováno v: Membranes, Vol 13, Iss 4, p 366 (2023)

Chlamydia trachomatis is the bacterial pathogen that causes most cases of sexually transmitted diseases annually. To combat the global spread of asymptomatic infection, development of effective (mucosal) vaccines that offer both systemic and local im

Externí odkaz: https://doaj.org/article/d75931d18129452291731094b67f4093

Distinct Requirements for Tail-Anchored Membrane Protein Biogenesis in Escherichia coli

Autor: Markus Peschke, Mélanie Le Goff, Gregory M. Koningstein, Norbert O. Vischer, Abbi Abdel-Rehim, Stephen High, Peter van Ulsen, Joen Luirink

Publikováno v: mBio, Vol 10, Iss 5 (2019)

ABSTRACT Tail-anchored membrane proteins (TAMPs) are a distinct subset of inner membrane proteins (IMPs) characterized by a single C-terminal transmembrane domain (TMD) that is responsible for both targeting and anchoring. Little is known about the r

Externí odkaz: https://doaj.org/article/5a939ea9bcec43ba9f5d870883c209e8

Comparing autotransporter β-domain configurations for their capacity to secrete heterologous proteins to the cell surface.

Autor: Wouter S P Jong, Maaike Schillemans, Corinne M Ten Hagen-Jongman, Joen Luirink, Peter van Ulsen

Publikováno v: PLoS ONE, Vol 13, Iss 2, p e0191622 (2018)

Monomeric autotransporters have been extensively used for export of recombinant proteins to the cell surface of Gram-negative bacteria. A bottleneck in the biosynthesis of such constructs is the passage of the outer membrane, which is facilitated by

Externí odkaz: https://doaj.org/article/3cf19bf742dd4f01ad08973fcb24b2ac

A Functional Carbohydrate Degrading Enzyme Potentially Acquired by Horizontal Gene Transfer in the Genome of the Soil Invertebrate Folsomia candida

Autor: Dick Roelofs, Abraham Brouwer, Peter Van Ulsen, Ngoc Giang Le, R.J.M. Van Spanning, Nico M. Van Straalen

Publikováno v: Le, N G, van Ulsen, P, van Spanning, R, Brouwer, A, van Straalen, N M & Roelofs, D 2022, ' A Functional Carbohydrate Degrading Enzyme Potentially Acquired by Horizontal Gene Transfer in the Genome of the Soil Invertebrate Folsomia candida ', Genes, vol. 13, no. 8, 1402, pp. 1-11 . https://doi.org/10.3390/genes13081402
Genes; Volume 13; Issue 8; Pages: 1402
Genes, 13(8):1402, 1-11. Multidisciplinary Digital Publishing Institute (MDPI)

Horizontal gene transfer (HGT) is defined as the acquisition by an organism of hereditary material from a phylogenetically unrelated organism. This process is mostly observed among bacteria and archaea, and considered less likely between microbes and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d7c5fc6edc7e92d3e1297e68f52026a
https://research.vu.nl/en/publications/927dbe02-e9e9-4290-894a-356c8194c1b2