The use of recovery animals in nonclinical safety assessment studies with monoclonal antibodies: further 3Rs opportunities remain

Autor: Helen Prior, Laura Andrews, Annick Cauvin, Hsiaotzu Chien, David O. Clarke, Kaushik Datta, Maggie Dempster, Noel Dybdal, Wendy Freebern, Lolke de Haan, Danuta Herzyk, Adam Hey, Thomas Kissner, Sven Kronenberg, Michael W. Leach, Donna Lee, Kirsty Reid, Katrin Schutte, Fiona Sewell, Kevin Trouba, Peter Ulrich, Leon van Aerts, Peter van Meer, Lucinda Weir

Publikováno v: Regulatory Toxicology and Pharmacology. 138:105339

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4146fe9c04d39dfa50daeca91bc58f4b
https://doi.org/10.1016/j.yrtph.2023.105339

An 80-Amino Acid Deletion in the Third Intracellular Loop of a Naturally Occurring Human Histamine H3 Isoform Confers Pharmacological Differences and Constitutive Activity

Autor: Peter van Meer, Marlon D. Cowart, Marina Strakhova, David G. Witte, John L. Baranowski, Rob Leurs, Arthur A. Hancock, Brian R. Estvander, Gerold Bongers, Thomas R. Miller, Kathleen M. Krueger, Remko A. Bakker, Timothy A. Esbenshade

Publikováno v: The Journal of Pharmacology and Experimental Therapeutics, 323(3), 888-98. American Society for Pharmacology and Experimental Therapeutics
Bongers, G M, Krueger, K M, Miller, T R, Baranowski, J L, Estvander, B R, Witte, D G, Strakhova, M I, van der Meer, P, Bakker, R A, Cowart, M D, Hancock, A A, Esbenshade, T A & Leurs, R 2007, ' An 80-amino acid deletion in the third intracellular loop of a naturally occurring human histamine H3 isoform confers pharmacological differences and constitutive activity ', The Journal of Pharmacology and Experimental Therapeutics, vol. 323, no. 3, pp. 888-98 . https://doi.org/10.1124/jpet.107.127639

In this article, we pharmacologically characterized two naturally occurring human histamine H3 receptor (hH3R) isoforms, hH3R(445) and hH3R(365). These abundantly expressed splice variants differ by a deletion of 80 amino acids in the intracellular l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::062d4248884dcb2bada0b5a82bba63e3
https://doi.org/10.1124/jpet.107.127639

Mouse behavioural analysis in systems biology

Autor: Jacob Raber, Peter Van Meer

Publikováno v: Biochemical Journal. 389:593-610

Molecular techniques allowing in vivo modulation of gene expression have provided unique opportunities and challenges for behavioural studies aimed at understanding the function of particular genes or biological systems under physiological or patholo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba01c9b2d25d1e88e0794e5a40e9c2f2
https://doi.org/10.1042/bj20042023

Acetylcholine receptor and behavioral deficits in mice lacking apolipoprotein E

Autor: Theodore S. Benice, Jacob Raber, Jessica A. Siegel, Byung Park, Peter Van Meer

Apolipoprotein E (apoE) is involved in the risk to develop sporadic Alzheimer’s disease (AD). Since impaired central acetylcholine (ACh) function is a hallmark of AD, apoE may influence ACh function by modulating muscarinic ACh receptors (mAChRs).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::255eff4fe382258f1242772e5db36386
https://europepmc.org/articles/PMC3172704/

Reduced histamine levels and H3receptor antagonist-induced histamine release in the amygdala of Apoe?/? mice

Autor: Jacob Raber, Peter Van Meer, Tim Pfankuch

Publikováno v: Journal of Neurochemistry. :070615193023001

The histamine H(3) receptor is a constitutively active G protein-coupled receptor for the neurotransmitter histamine that serves a negative feedback function. A role for the histamine H(3) receptor has been suggested in neurodegenerative diseases, su

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::410025a999517b8d293cf1c0722d212d
https://doi.org/10.1111/j.1471-4159.2007.04705.x