Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Peter Zucker"'
Publikováno v:
Annals of the New York Academy of Sciences. 958:175-178
MHC class III genes are important in immune regulation and inflammation, and the gene products of this region are well conserved between species. Their role in diabetes is, however, unknown. We used islets from NOD mice that lacked expression of both
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51085573d2cb670663ba948d42fd8c10
https://doi.org/10.1111/j.1749-6632.2002.tb02964.x
https://doi.org/10.1111/j.1749-6632.2002.tb02964.x
Publikováno v:
Transplantation. 78:509-515
BACKGROUND Major histocompatibility complex (MHC) molecules are essential determinants of beta-cell destruction in type 1 diabetes (T1D). MHC class I- or class II-null nonobese diabetic (NOD) mice do not spontaneously develop autoimmune diabetes and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbcfae1ae81dc5270252bfbc1360360a
https://doi.org/10.1097/01.tp.0000128907.83111.c6
https://doi.org/10.1097/01.tp.0000128907.83111.c6
Publikováno v:
Diabetes. 53:1303-1310
In nonobese diabetic (NOD) mice, a deficiency in the number and function of invariant natural killer T-cells (iNKT cells) contributes to the onset of type 1 diabetes. The activation of CD1d-restricted iNKT cells by alpha-galactosylceramide (alpha-Gal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac03ef7dfce7838465dfd4e18ce03b5f
https://doi.org/10.2337/diabetes.53.5.1303
https://doi.org/10.2337/diabetes.53.5.1303
Autor:
T. Craig Meagher, Terry L. Delovitch, Peter Zucker, Konstantin V. Salojin, Wei Chen, Marsha Grattan, Qing Sheng Mi
Publikováno v:
Endocrinology. 145:627-638
IGF-I regulates islet β-cell growth, survival, and metabolism and protects against type 1 diabetes (T1D). However, the therapeutic efficacy of free IGF-I may be limited by its biological half-life in vivo. We investigated whether prolongation of its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d5a25f284065b5481a2ef78c889a4c7
https://doi.org/10.1210/en.2003-1274
https://doi.org/10.1210/en.2003-1274
Publikováno v:
Journal of Molecular Medicine. 80:290-300
Natural killer T (NKT) cells express phenotypic characteristics shared by conventional natural killer cells and T cells, and reside in several primary and secondary lymphoid as well as nonlymphoid organs. Although these cells possess important effect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f534924aa4bd319e71666156c08137e
https://doi.org/10.1007/s00109-002-0332-8
https://doi.org/10.1007/s00109-002-0332-8
Publikováno v:
Transplantation. 71:982-985
The injury of transplanted islets may occur by both autoimmune and alloimmune processes directed against MHC targets. To examine the role of MHC class I in islet graft injury, we transplanted syngeneic and allogeneic beta2-microglobulin-deficient isl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a27a39899a15bcea9b687460d6895f8
https://doi.org/10.1097/00007890-200104150-00025
https://doi.org/10.1097/00007890-200104150-00025
Autor:
H.-Michael Dosch, Enrico Arpaia, Peter Zucker, Wolfram Karges, Igor Astsaturov, Marc Pilon, Bhagirath Singh, Denise Hammond-McKibben, Roger Gaedigk, Colin McKerlie, Shawn Winer, Aihua Song, Violetta Kubiak
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 168(1)
ICA69 (islet cell Ag 69 kDa) is a diabetes-associated autoantigen with high expression levels in β cells and brain. Its function is unknown, but knockout of its Caenorhabditis elegans homologue, ric-19, compromised neurotransmission. We disrupted th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc062d858019070c4e6148eddf764277
https://pubmed.ncbi.nlm.nih.gov/11751995
https://pubmed.ncbi.nlm.nih.gov/11751995
Autor:
Yasuhiko Koezuka, Toshinori Nakayama, Françoise Lepault, Agathe Hameg, Olga V. Naidenko, Mitchell Kronenberg, Qing Sheng Mi, Jean-Marc Gombert, Ren Zhu, Masaru Taniguchi, Peter Zucker, André Herbelin, Jean-François Bach, Jitin Sondhi, Christine Gouarin, Maria Leite-de-Moraes, Terry L. Delovitch, Agnès Lehuen, Guillermo A. Arreaza, Shayan Sharif
Publikováno v:
Nature medicine. 7(9)
Type 1 diabetes (T1D) in non-obese diabetic (NOD) mice may be favored by immune dysregulation leading to the hyporesponsiveness of regulatory T cells and activation of effector T-helper type 1 (Th1) cells. The immunoregulatory activity of natural kil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::457078fe7adbf0456bfa236f0a9bfed5
https://pubmed.ncbi.nlm.nih.gov/11533711
https://pubmed.ncbi.nlm.nih.gov/11533711
Autor:
Margaret T. Behme, David W. Scharp, Paul Atkison, John Dupré, Calvin R. Stiller, Irene Hramiak, Terri Paul, Barbera J Olack, Paul E. Lacy, Peter Zucker
Publikováno v:
Diabetes care. 19(3)
OBJECTIVE The majority of islet transplant recipients remain insulin-requiring, although many have near-normal connecting peptide (CP) levels. Insulin resistance may be one possible cause of the continuing need for exogenous insulin in islet transpla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::912c92c152dd3a509c0b50b1c975f5c0
https://pubmed.ncbi.nlm.nih.gov/8742568
https://pubmed.ncbi.nlm.nih.gov/8742568
Autor:
Dominic Pilon, Kruti Joshi, John J Sheehan, Miriam L Zichlin, Peter Zuckerman, Patrick Lefebvre, Paul E Greenberg
Publikováno v:
PLoS ONE, Vol 16, Iss 4, p e0249731 (2021)
[This corrects the article DOI: 10.1371/journal.pone.0223255.].
Externí odkaz:
https://doaj.org/article/7f30986dfcb04bc095f71f180f70fa57