Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Peter Zafian"'
Autor:
Margaret Wu, Ester Carballo-Jane, Haihong Zhou, Peter Zafian, Ge Dai, Mindy Liu, Julie Lao, Terri Kelly, Dan Shao, Judith Gorski, Dmitri Pissarnitski, Ahmet Kekec, Ying Chen, Stephen F. Previs, Giovanna Scapin, Yacob Gomez-Llorente, Scott A. Hollingsworth, Lin Yan, Danqing Feng, Pei Huo, Geoffrey Walford, Mark D. Erion, David E. Kelley, Songnian Lin, James Mu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/d6d3fdb3039843b9b530ac94e6eb34d2
Autor:
Margaret Wu, Ester Carballo-Jane, Haihong Zhou, Peter Zafian, Ge Dai, Mindy Liu, Julie Lao, Terri Kelly, Dan Shao, Judith Gorski, Dmitri Pissarnitski, Ahmet Kekec, Ying Chen, Stephen F. Previs, Giovanna Scapin, Yacob Gomez-Llorente, Scott A. Hollingsworth, Lin Yan, Danqing Feng, Pei Huo, Geoffrey Walford, Mark D. Erion, David E. Kelley, Songnian Lin, James Mu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Abstract Insulin analogs have been developed to treat diabetes with focus primarily on improving the time action profile without affecting ligand-receptor interaction or functional selectivity. As a result, inherent liabilities (e.g. hypoglycemia) of
Externí odkaz:
https://doaj.org/article/12bfc20a079d44f5b507280558359df6
Autor:
Dmitri A. Pissarnitski, Ahmet Kekec, Lin Yan, Yuping Zhu, Danqing D. Feng, Pei Huo, Christina Madsen-Duggan, Christopher R. Moyes, Ravi P. Nargund, Terri Kelly, Xiaoping Zhang, Ester Carballo-Jane, Judith Gorski, Peter Zafian, Mo Qatanani, Niels Kaarsholm, Fanyu Meng, Xiujuan Jia, Keun-Joong Lee, Weixun Wang, Sherrie Xu, Michael J. Hohn, Michael J. Iammarino, Mark A. McCoy, Grace A. Okoh, Yingkai Liang, Scott A. Hollingsworth, Mark D. Erion, David E. Kelley, Robert M. Garbaccio, Amy Zhang, James Mu, Songnian Lin
Publikováno v:
Journal of Medicinal Chemistry. 65:5593-5605
We have identified a series of novel insulin receptor partial agonists (IRPAs) with a potential to mitigate the risk of hypoglycemia associated with the use of insulin as an antidiabetic treatment. These molecules were designed as dimers of native in
Autor:
Margaret Wu, Ester Carballo-Jane, Haihong Zhou, Peter Zafian, Ge Dai, Mindy Liu, Julie Lao, Terri Kelly, Dan Shao, Judith Gorski, Dmitri Pissarnitski, Ahmet Kekec, Ying Chen, Stephen F. Previs, Giovanna Scapin, Yacob Gomez Llorente, Scott A. Hollingsworth, Lin Yan, Danqing Feng, Pei Huo, Geoffrey Walford, Mark D. Erion, David E. Kelley, Songnian Lin, James Mu
Publikováno v:
Nature communications. 13(1)
Insulin analogs have been developed to treat diabetes with focus primarily on improving the time action profile without affecting ligand-receptor interaction or functional selectivity. As a result, inherent liabilities (e.g. hypoglycemia) of injectab
Autor:
Bao Jen Shyong, David G. McLaren, Maria Webb, Joel Mane, Stephen F. Previs, Haihong Zhou, David E. Kelley, Carlos G. Rodriguez, Kevin P. Bateman, Yichen Wang, Daniel P. Downes, Natalie A. Daurio, George H. Addona, Andrea K. Houghton, Ying Chen, Peter Zafian, Ester Carballo-Jane, Rena Zhang
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 316:E1105-E1117
The regulation of nutrient homeostasis, i.e., the ability to transition between fasted and fed states, is fundamental in maintaining health. Since food is typically consumed over limited (anabolic) periods, dietary components must be processed and st
Autor:
Geoffrey Walford, Julie Lao, Terri M. Kelly, Haihong Zhou, Danqing Feng, Stephen F. Previs, Songnian Lin, Ahmet Kekec, Ying Chen, Mark D. Erion, Margaret Wu, Ester Carballo-Jane, Peter Zafian, Dmitri A. Pissarnitski, Pei Huo, James Mu, Scott A. Hollingsworth, Lin Yan, David E. Kelley, Mindy Liu, Ge Dai, Yacob Gomez-Llorente, Judith N. Gorski, Giovanna Scapin
Since its debut a century ago, insulin therapies have saved many lives and are now routinely used by patients with diabetes to manage hyperglycemia. Exemplary early studies of insulin molecular pathways led to the realization of the critical roles of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f553c0cd3d136dc33bbb79352a04f347
https://doi.org/10.21203/rs.3.rs-351091/v1
https://doi.org/10.21203/rs.3.rs-351091/v1
Autor:
Theresa M. Kelly, Franklin Liu, Ravi P. Nargund, Margaret van Heek, Pei Huo, Shuai Shi, Yan Cui, Joseph L. Duffy, Mark D. Erion, Sandra C. Souza, Aimie Ogawa, Ester Carballo-Jane, Vijay Bhasker G. Reddy, Songnian Lin, Valentyn Antochshuk, Yonghua Zhu, James Mu, Ge Dai, David E. Kelley, Lin Yan, Niels C. Kaarsholm, Margaret Wu, Peter Zafian, Wolfgang Seghezzi
Publikováno v:
Diabetes
Insulin has a narrow therapeutic index, reflected in a small margin between a dose that achieves good glycemic control and one that causes hypoglycemia. Once injected, the clearance of exogenous insulin is invariant regardless of blood glucose, aggra
Publikováno v:
Metabolism. 60:1627-1633
Although the use of radioisotopes in the investigation of glucose metabolism dates back more than 50 years, several relevant quantitative aspects have not been definitively determined. These include the volume of distribution (V(d)) of glucose and re
Autor:
Franklin Liu, Joseph L. Duffy, Niels C. Kaarsholm, Ge Dai, Margaret Wu, Peter Zafian, Ravi P. Nargund, Valentyn Antochshuk, Theresa M. Kelly, Vijay Bhasker G. Reddy, Margaret van Heek, Shuai Shi, Mark D. Erion, Sandra C. Souza, Lin Yan, Yan Cui, Wolfgang Seghezzi, Aimie Ogawa, James Mu, Ester Carballo-Jane, Pei Huo, David E. Kelley, Songnian Lin, Yonghua Zhu
Publikováno v:
Diabetes. 67:1030-1030
In the above-mentioned article, several scientists were erroneously omitted from the acknowledgments section. The authors wish to acknowledge Hsuan-shen Chen, Huaibing He, Tina …
Autor:
Rui Liang, Lauri M. Tota, Kevin T. Chapman, Joseph L. Duffy, Xiaodong Yang, Frank Xiaoqing Liu, Guoqiang Jiang, Edward J. Brady, Brian A. Kirk, Song Zheng, Zenon Konteatis, James R. Tata, Mari R. Candelore, Deborah Szalkowski, Sharon Tong, Bei B. Zhang, Victor D.-H. Ding, Elizabeth Louise Campbell, Richard Saperstein, Sajjad A. Qureshi, Dan Xie, Peter Zafian
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:1401-1405
A novel class of antagonists of the human glucagon receptor (hGCGR) has been discovered. Systematic modification of the lead compound identified substituents that were essential for activity and those that were amenable to further optimization. This