Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Peter Yehl"'
Publikováno v:
Analytical Chemistry. 94:16960-16966
The chemistry of guide RNA (gRNA) affects the performance of the clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 genome editing technique. However, the literature is very scarce about the study of gRNA degradation and in parti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::053e4fd05b2a7ea1bd8fd025671568ba
https://doi.org/10.1021/acs.analchem.2c04681
https://doi.org/10.1021/acs.analchem.2c04681
Autor:
Alexandre Goyon, Brandon Scott, Kenji Kurita, Chad Maschinot, Kevin Meyer, Peter Yehl, Kelly Zhang
Publikováno v:
Analytical Chemistry. 94:1169-1177
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5cc15d0a9f51518df6cb8bf986a35d3f
https://doi.org/10.1021/acs.analchem.1c04350
https://doi.org/10.1021/acs.analchem.1c04350
Autor:
Colin Masui, Peter Yehl, Chong Han, Kelly Zhang, Francis Gosselin, Lauren E. Sirois, Alexandre Goyon
Publikováno v:
Analytical Chemistry. 92:15187-15193
Automated high-throughput experimentation (HTE) is a powerful tool for scientists to explore and optimize chemical transformations by simultaneously screening yield, stereoselectivity, and impurity profiles. To analyze the HTE samples, high-throughpu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa396fae09988b4c88d56a731f7a6699
https://doi.org/10.1021/acs.analchem.0c03754
https://doi.org/10.1021/acs.analchem.0c03754
Autor:
Alexandre, Goyon, Brandon, Scott, Kenji, Kurita, Chad, Maschinot, Kevin, Meyer, Peter, Yehl, Kelly, Zhang
Publikováno v:
Analytical chemistry. 94(2)
In this study, for the first time, the automated digestion and sequencing of an RNA molecule
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f916ed8d68f64ccde1051ee17ef7c425
https://pubmed.ncbi.nlm.nih.gov/34932902
https://pubmed.ncbi.nlm.nih.gov/34932902
Autor:
Kenji L. Kurita, Peter Yehl, Andy A. Lin, Brandon Scott, Kelly Zhang, Christopher M. Crittenden, David E. Shaw, Alexandre Goyon
Publikováno v:
Analytical chemistry. 93(44)
CRISPR/Cas9 is a powerful genome editing approach in which a Cas9 enzyme and a single guide RNA (sgRNA) form a ribonucleoprotein complex effectively targeting site-specific cleavages of DNA. Accurate sequencing of sgRNA is critical to patient safety
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a51f1705dd36cb0d8b129e187410ae1d
https://pubmed.ncbi.nlm.nih.gov/34699173
https://pubmed.ncbi.nlm.nih.gov/34699173
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 220:114962
Drug formulations such as spray drying are often required to improve the physicochemical properties and bioavailability of hydrophobic drugs. However, excipients often carry contaminants/ impurities and may also increase moisture levels in solid form
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::681558e08bc424fb91563f6bf002c681
https://doi.org/10.1016/j.jpba.2022.114962
https://doi.org/10.1016/j.jpba.2022.114962
Autor:
Chun-Wan Yen, Lu Dai, Steven Chin, Brian Roper, Elizabeth S. Hecht, Chloe Hu, Cadapakam Venkatramani, Nisana Andersen, Robert Kuhn, Dennis Leung, Fiona Lin, Jason Gruenhagen, Christopher M. Crittenden, Alberto Estevez, Mohammad Al-Sayah, Amin Famili, Lance Cadang, Tao Chen, Shijia Tang, Cinzia Stella, Karthik Nagapudi, Peter Yehl, Richard Vandlen, Peter Liu, Alexis Rohou, Debby P. Chang, Rami N. Hannoush
Publikováno v:
Journal of Pharmaceutical Sciences.
Constrained peptides (CPs) have emerged as attractive candidates for drug discovery and development. To fully unlock the therapeutic potential of CPs, it is crucial to understand their physical stability and minimize the formation of aggregates that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e078389a18d4495af32516044ad50a61
https://doi.org/10.1016/j.xphs.2020.12.041
https://doi.org/10.1016/j.xphs.2020.12.041
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 197
With advanced genetic engineering technologies and better understanding of disease biology, antibody-based therapeutics are emerging as promising new generation biopharmaceuticals. These novel antibody formats are carefully designed to possess desire
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::627054272b7773b04c31020fa7659c4c
https://pubmed.ncbi.nlm.nih.gov/33601156
https://pubmed.ncbi.nlm.nih.gov/33601156
Autor:
Dawen Kou, Larry Wigman, Chen Zhang, Tania Ng, Matthew R. Durk, Hiuwing Yiu, Leslie W. Chinn, Matthew Janson, Joseph W. Lubach, Peter Yehl, Helen Winter, Chen Mao
Publikováno v:
Molecular Pharmaceutics. 15:1607-1617
In this study, a multipronged approach of in vitro experiments, in silico simulations, and in vivo studies was developed to evaluate the dissolution, supersaturation, precipitation, and absorption of three formulations of Compound-A, a BCS class 2 we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::089b0b2c7a67f49cbf57aa2ec0c18685
https://doi.org/10.1021/acs.molpharmaceut.7b01143
https://doi.org/10.1021/acs.molpharmaceut.7b01143
Publikováno v:
Organic Process Research & Development. 21:182-186
Boronic acids and boronate esters are commonly used reagents in Suzuki–Miyaura coupling chemistry which are known to be weakly mutagenic in microbial assays. In this paper, we describe an inductively coupled plasma mass spectrometer method (ICP-MS)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2d0e72592f42445e31440af03a154cc
https://doi.org/10.1021/acs.oprd.6b00325
https://doi.org/10.1021/acs.oprd.6b00325