The Glomerular Filtration Barrier: Components and Crosstalk

Autor: Madhav C. Menon, Peter Y. Chuang, Cijiang John He

Publikováno v: International Journal of Nephrology, Vol 2012 (2012)

The glomerular filtration barrier is a highly specialized blood filtration interface that displays a high conductance to small and midsized solutes in plasma but retains relative impermeability to macromolecules. Its integrity is maintained by physic

Externí odkaz: https://doaj.org/article/42d2997bf6aa41709e4d8c0143f88c08

cAMP signaling prevents podocyte apoptosis via activation of protein kinase A and mitochondrial fusion.

Autor: Xiaoying Li, Hua Tao, Kewei Xie, Zhaohui Ni, Yucheng Yan, Kai Wei, Peter Y Chuang, John Cijiang He, Leyi Gu

Publikováno v: PLoS ONE, Vol 9, Iss 3, p e92003 (2014)

Our previous in vitro studies suggested that cyclic AMP (cAMP) signaling prevents adriamycin (ADR) and puromycin aminonucleoside (PAN)-induced apoptosis in podocytes. As cAMP is an important second messenger and plays a key role in cell proliferation

Externí odkaz: https://doaj.org/article/3a87ced7ae3c4058a1219b26988959f8

Increased podocyte Sirtuin-1 function attenuates diabetic kidney injury

Autor: Lu Zhang, Guangyan Cai, Bohan Liu, Bhaskar C. Das, Quan Hong, Zhengzhe Li, Xiangmei Chen, Kyung Lee, Peter Y. Chuang, John Cijiang He

Publikováno v: Kidney International. 93:1330-1343

Podocyte injury and loss contribute to the progression of glomerular diseases, including diabetic kidney disease. We previously found that the glomerular expression of Sirtuin-1 (SIRT1) is reduced in human diabetic glomeruli and that the podocyte-spe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fe2f91e1024fd80b4557fc810a89b12
https://doi.org/10.1016/j.kint.2017.12.008

Alteration of forkhead box O (foxo4) acetylation mediates apoptosis of podocytes in diabetes mellitus.

Autor: Peter Y Chuang, Yan Dai, Ruijie Liu, Helen He, Matthias Kretzler, Belinda Jim, Clemens D Cohen, John C He

Publikováno v: PLoS ONE, Vol 6, Iss 8, p e23566 (2011)

The number of kidney podocytes is reduced in diabetic nephropathy. Advanced glycation end products (AGEs) accumulate in patients with diabetes and promote the apoptosis of podocyte by activating the forkhead box O4 (Foxo4) transcription factor to inc

Externí odkaz: https://doaj.org/article/c7f5ae50360e4b479665339a4480a223

Retinoic acid improves nephrotoxic serum–induced glomerulonephritis through activation of podocyte retinoic acid receptor α

Autor: Yan Dai, Xiaoqiang Ding, Weijing Cai, Marcus J. Moeller, Stuart J. Shankland, Shuchita Sharma, Norbert B. Ghyselinck, Jeffrey Pippin, Ruijie Liu, Kyung Lee, John Cijiang He, Anqun Chen, Leyi Gu, David J. Salant, Fadi Salem, Peter Y. Chuang

Publikováno v: Kidney International
Kidney International, Nature Publishing Group, 2017, 92 (6), pp.1444-1457. ⟨10.1016/j.kint.2017.04.026⟩
Kidney International, 2017, 92 (6), pp.1444-1457. ⟨10.1016/j.kint.2017.04.026⟩

Proliferation of glomerular epithelial cells, including podocytes, is a key histologic feature of crescentic glomerulonephritis. We previously found that retinoic acid (RA) inhibits proliferation and induces differentiation of podocytes by activating

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91fc258a2364f2811cfb7836ffdcf0b7
https://hal.archives-ouvertes.fr/hal-02324133/document