Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Peter Wipfli"'
Autor:
Nicolau Beckmann, Elisa Giorgetti, Anna Neuhaus, Stefan Zurbruegg, Nathalie Accart, Paul Smith, Julien Perdoux, Ludovic Perrot, Mark Nash, Sandrine Desrayaud, Peter Wipfli, Wilfried Frieauff, Derya R. Shimshek
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-17 (2018)
Abstract Multiple sclerosis (MS) is a chronic inflammatory disease affecting the central nervous system (CNS). While multiple effective immunomodulatory therapies for MS exist today, they lack the scope of promoting CNS repair, in particular remyelin
Externí odkaz:
https://doaj.org/article/9fdc2fc9f13842ac8f3b0d040aeb08ed
Autor:
John Isbell, Laurent Hoffmann, Leonel Reis da Silva Torrao, Peter Wipfli, Ding Yuan, Ewa Gatlik
Publikováno v:
Journal of Pharmaceutical Sciences. 108:1053-1060
Accurate determination of the free fraction of a drug in plasma can be challenging when it falls below 1% and even more so when below 0.1%. Equilibrium dialysis with diluted plasma has been used to determine unbound fraction below 1%, but some analyt
Autor:
Nathalie Accart, Elisa Giorgetti, Stefan Zurbruegg, Sandrine Desrayaud, Mark Nash, Ludovic Perrot, Paul Smith, Derya R. Shimshek, Wilfried Frieauff, Peter Wipfli, Anna Neuhaus, Nicolau Beckmann, Julien Perdoux
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-17 (2018)
Acta Neuropathologica Communications
Acta Neuropathologica Communications
Multiple sclerosis (MS) is a chronic inflammatory disease affecting the central nervous system (CNS). While multiple effective immunomodulatory therapies for MS exist today, they lack the scope of promoting CNS repair, in particular remyelination. Mi
Autor:
Roland Feifel, Philip C. Smith, Ursula Bodendorf, Robert Epple, Philippe Couttet, Reiner Aichholz, Danilo Guerini, Ina Dix, Ben Wen, Bo Liu, Peter Wipfli, Juraj Velcicky, Toni Widmer, Trixi Brandl, Daniel R. Beisner, Pascal Rigollier
Publikováno v:
Journal of Medicinal Chemistry. 61:865-880
Signal peptide peptidase-like 2a (SPPL2a) is an aspartic intramembrane protease which has recently been shown to play an important role in the development and function of antigen presenting cells such as B lymphocytes and dendritic cells. In this pap
Autor:
Sandrine Desrayaud, Francis Risser, Catherine Afatsawo, Daniel Lehmann, Philip Arabin, Valerie Cordier, Laurent Hoffmann, Toni Widmer, Peter Wipfli, Marc Bigaud, Julia Thiel, Phil Lowe, Rowan Stringer
1. The utility of 1-aminobenzotriazole (ABT), incorporated in food, has been investigated as an approach for longer term inhibition of cytochrome P450 (P450) enzymes in mice. 2. In rats, ABT inhibits gastric emptying, to investigate this potential li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fb256f3c00f7612540ff67c495f1665
Autor:
Thomas Vorherr, Peter Wipfli, Michael Schaefer, Trixie Wagner, Lukas Oberer, Ian Lewis, Emine Sager
Publikováno v:
International Journal of Peptide Research and Therapeutics. 21:205-221
This contribution provides detailed insights regarding permeability properties of published cyclohexapeptides related to their conformation. The study includes data on oral bioavailability and PK parameters including application of a known enhancer.
Publikováno v:
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 792(2)
An analytical method was developed for the quantification of tezosentan in human plasma obtained in clinical studies. The method was linear in the range 1 to 512 ng/ml. After liquid-liquid extraction, the samples were analyzed by reversed-phase HPLC