Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Peter Wend"'
Autor:
Peter Wend, Stephanie Runke, Korinna Wend, Brenda Anchondo, Maria Yesayan, Meghan Jardon, Natalie Hardie, Christoph Loddenkemper, Ilya Ulasov, Maciej S. Lesniak, Rebecca Wolsky, Laurent A. Bentolila, Stephen G. Grant, David Elashoff, Stephan Lehr, Jean J. Latimer, Shikha Bose, Husain Sattar, Susan A. Krum, Gustavo A. Miranda‐Carboni
Publikováno v:
EMBO Molecular Medicine, Vol 5, Iss 2, Pp 264-279 (2013)
Abstract Wnt/β‐catenin signalling has been suggested to be active in basal‐like breast cancer. However, in highly aggressive metastatic triple‐negative breast cancers (TNBC) the role of β‐catenin and the underlying mechanism(s) for the aggr
Externí odkaz:
https://doaj.org/article/bfd88c16d16f4a579876003647e84448
Autor:
Gustavo A. Miranda-Carboni, Susan A. Krum, Victoria Seewaldt, Tiffany N. Seagroves, William E. Lowry, Ruth M. O'Regan, Lily Yang, Lisa D. Yee, Robert Cardiff, Andrew C. White, Raisa I. Krutilina, Hilaire C. Barch, Stephan Lehr, Joseph K. Gray, Wendy Silva, Julio Silva, William L. Kuenzinger, Stephanie Runke, Jackelyn A. Alva-Ornelas, Peter Wend, Iram Fatima, Ikbale El Ayachi
Triple-negative breast cancer (TNBC) commonly develops resistance to chemotherapy, yet markers predictive of chemoresistance in this disease are lacking. Here, we define WNT10B-dependent biomarkers for β-CATENIN/HMGA2/EZH2 signaling predictive of re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cfbb347fc17e589e41a0e43ba5161ad7
https://doi.org/10.1158/0008-5472.c.6511163.v1
https://doi.org/10.1158/0008-5472.c.6511163.v1
Autor:
Gustavo A. Miranda-Carboni, Susan A. Krum, Victoria Seewaldt, Tiffany N. Seagroves, William E. Lowry, Ruth M. O'Regan, Lily Yang, Lisa D. Yee, Robert Cardiff, Andrew C. White, Raisa I. Krutilina, Hilaire C. Barch, Stephan Lehr, Joseph K. Gray, Wendy Silva, Julio Silva, William L. Kuenzinger, Stephanie Runke, Jackelyn A. Alva-Ornelas, Peter Wend, Iram Fatima, Ikbale El Ayachi
Supplementary Section: 1) Seven supplementary figures and legends: A. Supplementary figure S1: TCGA analysis of WNT10B network. B. Supplementary figure S2: Human IHC analysis of WNT10B, HMGA2 and EZH2. C. Supplementary figure S3: Mouse IHC analysis o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86d588ad2842fb0c7dd56c5ab217cf0a
https://doi.org/10.1158/0008-5472.22422239.v1
https://doi.org/10.1158/0008-5472.22422239.v1
Autor:
Ruth O'Regan, Susan A. Krum, Aysha B. Khalid, Victoria L. Seewaldt, William L. Kuenzinger, Lauren Brakefield, Ikbale El-Ayachi, Jackelyn A. Alva-Ornelas, Jackelyn C. Pence, Hilaire C. Playa, Gustavo A. Miranda-Carboni, Peter Wend, Tiffany N. Seagroves, Daniel L. Johnson, Iram Fatima, Raisa I. Krutilina
Publikováno v:
Cancers
Volume 11
Issue 12
Volume 11
Issue 12
Triple-negative breast cancers (TNBCs), which lack specific targeted therapy options, evolve into highly chemo-resistant tumors that metastasize to multiple organs simultaneously. We have previously shown that TNBCs maintain an activated WNT10B-drive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4793d94ed074fd05c6f0dbbf1308f0d
http://europepmc.org/articles/PMC6966654
http://europepmc.org/articles/PMC6966654
Autor:
Stephanie Runke, David Elashoff, Ilya V. Ulasov, Husain Sattar, Susan A. Krum, Christoph Loddenkemper, Brenda Anchondo, Rebecca J. Wolsky, Shikha Bose, Gustavo A. Miranda-Carboni, Korinna Wend, Maciej S. Lesniak, Natalie Hardie, Stephan Lehr, Laurent A. Bentolila, Stephen G. Grant, Meghan Jardon, Jean Johanna Latimer, Peter Wend, Maria Yesayan
Publikováno v:
EMBO Molecular Medicine
Wnt/β-catenin signalling has been suggested to be active in basal-like breast cancer. However, in highly aggressive metastatic triple-negative breast cancers (TNBC) the role of β-catenin and the underlying mechanism(s) for the aggressiveness of TNB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c97831ba94cb2ff72d0f6b6bf9957ab6
https://doi.org/10.1002/emmm.201201320
https://doi.org/10.1002/emmm.201201320
Publikováno v:
Acta Physiologica. 204:34-51
Wnt10b is a member of the Wnt ligand gene family that encodes for secreted proteins, which activate the ancient and highly conserved Wnt signalling cascade. The Wnt pathway has been shown to be essential for embryonic development, tissue integrity, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15ad5b4e1a7a3e0073a4bd195d4ac83c
https://doi.org/10.1111/j.1748-1716.2011.02296.x
https://doi.org/10.1111/j.1748-1716.2011.02296.x
Publikováno v:
Seminars in Cell & Developmental Biology. 21:855-863
Canonical Wnt signaling supports the formation and maintenance of stem and cancer stem cells. Recent studies have elucidated epigenetic mechanisms that control pluripotency and stemness, and allow a first assessment how embryonic and tissue stem cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::def248b0252579c6f06d37fe6d5687d9
https://doi.org/10.1016/j.semcdb.2010.09.004
https://doi.org/10.1016/j.semcdb.2010.09.004
Publikováno v:
Genes & Development. 22:2308-2341
Wnt signaling is one of a handful of powerful signaling pathways that play crucial roles in the animal life by controlling the genetic programs of embryonic development and adult homeostasis. When disrupted, these signaling pathways cause development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b31ecda0afea5a105a6f348af43456d
https://doi.org/10.1101/gad.1686208
https://doi.org/10.1101/gad.1686208
Autor:
Jochen C. Meier, Darko Markovic, Marie-Pierre Junier, Peter Wend, Aline Winkelmann, Helmut Kettenmann, Benjamin Förstera, Michael Synowitz, Bruno Benedetti, Rainer Glass, Omar Dzaye, Michael Fähling, Marcus Semtner
Publikováno v:
Journal of Cell Science.
The neuronal function of Cys-loop neurotransmitter receptors is established; however, their role in non-neuronal cells is poorly defined. As brain tumors are enriched in the neurotransmitter glycine, we studied the expression and function of glycine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01b13d6421664994073c6aaa9a94ee08
https://doi.org/10.1242/jcs.146662
https://doi.org/10.1242/jcs.146662
Autor:
Volker Brinkmann, Christoph Loddenkemper, Jörg Schipper, Ulrike Ziebold, Klaus Eckert, Walter Birchmeier, Qionghua Zhu, Frauke Kosel, Liang Fang, Michael Kahn, Peter Wend, Jane D. Holland, Simone Hindersin, Stephan Lehr
We show that activation of Wnt/{beta}-catenin and attenuation of Bmp signals, by combined gain- and loss-of-function mutations of {beta}-catenin and Bmpr1a, respectively, results in rapidly growing, aggressive squamous cell carcinomas (SCC) in the sa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef4e383522533df25ff9c359f1081730
http://edoc.mdc-berlin.de/13113/1/13113oa.pdf
http://edoc.mdc-berlin.de/13113/1/13113oa.pdf