Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Peter Warner"'
Autor:
H. Michael Petrassi, Gregory T. Robertson, Carl Nathan, Clifton E. Barry, Kelly Chibale, Dale J. Kempf, Helena I. Boshoff, Joël Lelièvre, Ken Duncan, Bree B. Aldridge, Jeremy M. Rock, Betsy Russell, Peter Warner, Fabian Gusovsky, Michael R. Schrimpf, Véronique Dartois, James C. Sacchettini, Nader Fotouhi, Anne J. Lenaerts, Robert H. Bates, Anna Upton, David B. Olsen, Dirk Schnappinger, David G. Russell, Case W. McNamara, David Barros-Aguirre, Tanya Parish, Kyu Y. Rhee, Philip Arthur Hipskind, Valerie Mizrahi, Paul G. Wyatt, Steven Joseph Berthel, Alexander Pym, Xin-Jie Chu, Eric J. Rubin, Ying Yuan, Christopher B. Cooper
Publikováno v:
Nature medicine. 27(8)
The Tuberculosis Drug Accelerator, an experiment designed to facilitate collaboration in tuberculosis drug discovery by breaking down barriers among competing labs and institutions, has reached a 10-year landmark. We review the consortium’s achieve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fca010dc18a791b197ac73fcbf7c0f4f
https://pubmed.ncbi.nlm.nih.gov/34226736
https://pubmed.ncbi.nlm.nih.gov/34226736
Publikováno v:
Madroño. 67
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc406974e3a7d2b1311d7b3d6cab670d
https://doi.org/10.3120/0024-9637-67.4.161
https://doi.org/10.3120/0024-9637-67.4.161
β-Hydroxy acyl ligands bound to (η5-C5H5)Fe(CO)(PPh3) are stereoselectively alkylated on the α-carbon to give after decomplexation erythro-β-hydroxy carboxylic acids.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e1abe7fd16dcf5e631ec4cd57f2e49b
https://ora.ox.ac.uk/objects/uuid:bed0d06c-8e3c-4adf-baef-f37ab4e14210
https://ora.ox.ac.uk/objects/uuid:bed0d06c-8e3c-4adf-baef-f37ab4e14210
The aluminium enolate derived from the iron acetyl complex [(η5-C5H5Fe(CO)(PPh3)COCH3], in contrast to the lithium enolate, undergoes highly stereoselective aldol reactions with aldehydes to generate RR,SS-β-hydroxyacyl complexes which on decomplex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6200de0a9daa93905cb9bfbec198738
https://doi.org/10.1016/0022-328x(85)87369-1
https://doi.org/10.1016/0022-328x(85)87369-1
Autor:
Charles E. Mowbray, Dennis Schmatz, Ken Duncan, Rob Hooft van Huijsduijnen, Takushi Kaneko, Peter Warner, B. T. Slingsby, Kiyoshi Kita, Jeremy N. Burrows, Kei Katsuno
Publikováno v:
Nature reviews. Drug discovery. 14(11)
Reducing the burden of infectious diseases that affect people in the developing world requires sustained collaborative drug discovery efforts. The quality of the chemical starting points for such projects is a key factor in improving the likelihood o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd2dfa4e2d0181eff07d0bd45d843ba9
https://pubmed.ncbi.nlm.nih.gov/27020099
https://pubmed.ncbi.nlm.nih.gov/27020099
Autor:
Shridhar Narayanan, Laura M. Sanz, Sreenivasaiah Menasinakai, Kevin Hickling, Abhishek Srivastava, Sapna Morayya, Anandkumar Raichurkar, Vikas Patil, Stefan Kavanagh, María Belén Jiménez-Díaz, Ramanatha Saralaya, Vijender Panduga, Gajanan Shanbag, Eknath V. Bellale, Lyn Rosenbrier-Ribeiro, K.R. Prabhakar, Anisha Ambady, David Waterson, Nikhil Rautela, Kannan Murugan, Pavithra Viswanath, Peter Warner, Pamela Magistrado, Pravin Iyer, Dyann F. Wirth, Jayashree Puttur, Krishna Koushik, Sowmya Bharath, Nilanjana Roy Choudhury, Philipp P. Henrich, Olivia Coburn-Flynn, Suresh Solapure, Radha Nandishaiah, Balachandra Bandodkar, Kakoli Mukherjee, María Santos Martínez, Suresh Rudrapatna, David A. Fidock, Shahul Hameed P, Vinayak Hosagrahara, Monalisa Chatterji, Vasan K. Sambandamurthy, V. Balasubramanian, Sudhir Landge, Jitendar Reddy, Robert E. McLaughlin, Amanda K. Lukens, Adam Jeston Dudley, Disha Awasthy
Publikováno v:
Nature Communications
The widespread emergence of Plasmodium falciparum (Pf) strains resistant to frontline agents has fuelled the search for fast-acting agents with novel mechanism of action. Here, we report the discovery and optimization of novel antimalarial compounds,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::039caecc0852bb3bd72abf0265b59ccf
https://doi.org/10.1038/ncomms7715
https://doi.org/10.1038/ncomms7715
Publikováno v:
Tetrahedron. 55:13495-13512
Cation-mediated cyclisation reactions of silyl enol ether-containing thioglycosides give bicyclic ketotetrahydrofurans. Cyclisation of an analogous 3-phenyl-2-propenyl ether-containing substrate gives an intermediate in the total synthesis of the hig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4ec6fd9b805d115b678febf007232ea
https://doi.org/10.1016/s0040-4020(99)00834-0
https://doi.org/10.1016/s0040-4020(99)00834-0
Publikováno v:
Tetrahedron Letters. 39:8325-8328
S -Glycosides possessing silyl enol ether groups tethered via an ether linkage undergo highly selective cation-mediated cyclisation reactions to give C -glycosidic ketotetrahydropyran-containing bicyclo[4.4.0] systems. These may be converted into a v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b703f3d09d27f18287ee395f5cb2a825
https://doi.org/10.1016/s0040-4039(98)01826-7
https://doi.org/10.1016/s0040-4039(98)01826-7
Publikováno v:
Tetrahedron Letters. 36:5815-5818
The total synthesis of the KDO-inhibitor 2,3-dideoxy-d-manno-2-octulopyranosonic acid (2-deoxy-KDO) starting from TBDPS-protected (S)-glycidol and 3,3-dimethoxy-1-(phenylsulfonyl)-propane is described. The key steps are silver(I) trifluoromethylsulfo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef020561c839005f823228687160407b
https://doi.org/10.1016/00404-0399(50)1104p-
https://doi.org/10.1016/00404-0399(50)1104p-
Publikováno v:
Tetrahedron Letters. 36:5815-5818
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a0b2dcc638dae3f78a8430a170ba1cc
https://doi.org/10.1016/0040-4039(95)01104-p
https://doi.org/10.1016/0040-4039(95)01104-p