Generation of a gene-corrected human isogenic iPSC line from an Alzheimer’s disease iPSC line carrying the PSEN1 H163R mutation

Autor: Damián Hernández, Stephanie Morgan Schlicht, Jordan Elli Clarke, Maciej Daniszewski, Celeste M. Karch, Alison M. Goate, Alice Pébay, Sarah Adams, Ricardo Allegri, Aki Araki, Nicolas Barthelemy, Randall Bateman, Jacob Bechara, Tammie Benzinger, Sarah Berman, Courtney Bodge, Sus Brandon, William (Bill) Brooks, Jared Brosch, Jill Buck, Virginia Buckles, Kathleen Carter, Lisa Cash, Charlie Chen, Jasmeer Chhatwal, Patricio Chrem Mendez, Jasmin Chua, Helena Chui, Laura Courtney, Carlos Cruchaga, Gregory S Day, Chrismary DeLaCruz, Darcy Denner, Anna Diffenbacher, Aylin Dincer, Tamara Donahue, Jane Douglas, Duc Duong, Noelia Egido, Bianca Esposito, Anne Fagan, Marty Farlow, Becca Feldman, Colleen Fitzpatrick, Shaney Flores, Nick Fox, Erin Franklin, Nelly Joseph-Mathurin, Hisako Fujii, Samantha Gardener, Bernardino Ghetti, Alison Goate, Sarah Goldberg, Jill Goldman, Alyssa Gonzalez, Brian Gordon, Susanne Gr¨aber-Sultan, Neill Graff-Radford, Morgan Graham, Julia Gray, Emily Gremminger, Miguel Grilo, Alex Groves, Christian Haass, Lisa H¨asler, Jason Hassenstab, Cortaiga Hellm, Elizabeth Herries, Laura Hoechst-Swisher, Anna Hofmann, David Holtzman, Russ Hornbeck, Yakushev Igor, Ryoko Ihara, Takeshi Ikeuchi, Snezana Ikonomovic, Kenji Ishii, Clifford Jack, Gina Jerome, Erik Johnson, Mathias Jucker, Celeste Karch, Stephan K¨aser, Kensaku Kasuga, Sarah Keefe, William Klunk, Robert Koeppe, Deb Koudelis, Elke Kuder-Buletta, Christoph Laske, Allan Levey, Johannes Levin, Yan Li, Oscar Lopez, Jacob Marsh, Ralph Martins, Neal Scott Mason, Colin Masters, Kwasi Mawuenyega, Austin McCullough, Eric McDade, Arlene Mejia, Estrella Morenas-Rodriguez, John Morris, James Mountz, Cath Mummery, Neelesh Nadkarni, Akemi Nagamatsu, Katie Neimeyer, Yoshiki Niimi, James Noble, Joanne Norton, Brigitte Nuscher, Ulricke Obermüller, Antoinette O’Connor, Riddhi Patira, Richard Perrin, Lingyan Ping, Oliver Preische, Alan Renton, John Ringman, Stephen Salloway, Peter Schofield, Michio Senda, Nicholas T Seyfried, Kristine Shady, Hiroyuki Shimada, Wendy Sigurdson, Jennifer Smith, Lori Smith, Beth Snitz, Hamid Sohrabi, Sochenda Stephens, Kevin Taddei, Sarah Thompson, Jonathan V¨oglein, Peter Wang, Qing Wang, Elise Weamer, Chengjie Xiong, Jinbin Xu, Xiong Xu

Publikováno v: Stem Cell Research, Vol 79, Iss , Pp 103495- (2024)

We report the generation of a gene-edited human induced pluripotent stem cell (iPSC) line from an Alzheimer’s disease patient-derived iPSC line harbouring the PSEN1 H163R mutation. This line demonstrates pluripotent stem cell morphology, expression

Externí odkaz: https://doaj.org/article/4ce9fc661d6c4996abc96e57738bae7d

Deep Learning and Drug Discovery for Healthy Aging

Autor: Peter Wang, Dean Ho

Publikováno v: ACS Central Science, Vol 9, Iss 10, Pp 1860-1863 (2023)

Externí odkaz: https://doaj.org/article/15c9f06ac1d948dc80ad35aab95a011b

Decoding the Role of O-GlcNAcylation in Hepatocellular Carcinoma

Autor: Xinyu Zhou, Sirui Hang, Qingqing Wang, Liu Xu, Peter Wang

Publikováno v: Biomolecules, Vol 14, Iss 8, p 908 (2024)

Post-translational modifications (PTMs) influence protein functionality by modulating protein stability, localization, and interactions with other molecules, thereby controlling various cellular processes. Common PTMs include phosphorylation, acetyla

Externí odkaz: https://doaj.org/article/30de686b95fa48c19b1d3041a1b69bc2

Strategies for a scalable multi-robot large scale wire arc additive manufacturing system

Autor: Alex Arbogast, Andrzej Nycz, Mark W. Noakes, Peter Wang, Christopher Masuo, Joshua Vaughan, Lonnie Love, Randall Lind, William Carter, Luke Meyer, Derek Vaughan, Alex Walters, Steven Patrick, Jonathan Paul, Jason Flamm

Publikováno v: Additive Manufacturing Letters, Vol 8, Iss , Pp 100183- (2024)

Conventional robotic wire arc additive manufacturing technologies enable the rapid production of moderate-sized components using low-cost wire feedstocks and robotic welding systems. Efforts to date have primarily focused on single robot solutions. H

Externí odkaz: https://doaj.org/article/0b10279359624672b8aeb22d8e7166e9

Heterogeneity in allospecific T cell function in transplant-tolerant hosts determines susceptibility to rejection following infection

Autor: Christine M. McIntosh, Jennifer B. Allocco, Peter Wang, Michelle L. McKeague, Alexandra Cassano, Ying Wang, Stephen Z. Xie, Grace Hynes, Ricardo Mora-Cartín, Domenic Abbondanza, Luqiu Chen, Husain Sattar, Dengping Yin, Zheng J. Zhang, Anita S. Chong, Maria-Luisa Alegre

Publikováno v: The Journal of Clinical Investigation, Vol 133, Iss 21 (2023)

Even when successfully induced, immunological tolerance to solid organs remains vulnerable to inflammatory insults, which can trigger rejection. In a mouse model of cardiac allograft tolerance in which infection with Listeria monocytogenes (Lm) preci

Externí odkaz: https://doaj.org/article/1eb856be313b4c5fbf4a11672afe782f