Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Peter WONEROW"'
Autor:
Hélène Bonnevaux, Stephane Guerif, Jana Albrecht, Erwan Jouannot, Thibaud De Gallier, Christian Beil, Christian Lange, Wulf Dirk Leuschner, Marion Schneider, Cendrine Lemoine, Anne Caron, Céline Amara, Cédric Barrière, Justine Siavellis, Valérie Bardet, Ernesto Luna, Pankaj Agrawal, Donald R. Drake, Ercole Rao, Peter Wonerow, Chantal Carrez, Véronique Blanc, Karl Hsu, Dmitri Wiederschain, Paula G. Fraenkel, Angéla Virone-Oddos
Publikováno v:
OncoImmunology, Vol 10, Iss 1 (2021)
Novel therapies are needed for effective treatment of AML. In the relapsed setting, prognosis is very poor despite salvage treatment with chemotherapy. Evidence suggests that leukemic stem cells (LSCs) cause relapse. The cell surface receptor CD123 i
Externí odkaz:
https://doaj.org/article/1e989dd4f1bc4fabbee1419fc76e4439
Publikováno v:
BioTechniques, Vol 27, Iss 2, Pp 266-268 (1999)
Externí odkaz:
https://doaj.org/article/8afe804f36d447cfb8cd873cd28db0df
Publikováno v:
European Journal of Clinical Pharmacology. 73:949-956
Glycoprotein VI (GPVI) is the major platelet receptor for collagen-mediated platelet adhesion and activation. SAR264565 is an anti-GPVI-Fab, binds to GPVI with high affinity, and blocks GPVI function in human platelets in vitro. The effect of SAR2645
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::506fe6c997d0294b2e12049034232400
https://doi.org/10.1007/s00228-017-2264-9
https://doi.org/10.1007/s00228-017-2264-9
Publikováno v:
Drug Development Research. 74:440-449
Preclinical Research Platelets are small anucleated cells produced by bone marrow megakaryocytes that circulate in the blood as sentinels of vascular integrity. They play a pivotal role in the regulation of vascular homeostasis through adhesion to th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::74424f708082990f30b7e3d38ebb7fa6
https://doi.org/10.1002/ddr.21101
https://doi.org/10.1002/ddr.21101
Autor:
Cécile Capdevila, Anke Steinmetz, Paul Ferrari, Ercole Rao, Christian Beil, François Vallée, Jochen Beninga, Nicolas Baurin, Alain Dupuy, Peter Wonerow, Christian Lange, Carsten Corvey, Alexey Rak, Jochen Kruip, Vincent Mikol
Bispecific immunoglobulins (Igs) typically contain at least two distinct variable domains (Fv) that bind to two different target proteins. They are conceived to facilitate clinical development of biotherapeutic agents for diseases where improved clin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae855717b44ed147472fecbda2b42ceb
https://europepmc.org/articles/PMC4968095/
https://europepmc.org/articles/PMC4968095/
Autor:
Justine Siavellis, Stephane Guerif, Agnès Vergezac, Ernesto Luna, Laurent Bassinet, Peter Wonerow, Ercole Rao, Corina Oprea, Karl Hsu, Anne Caron, Wulf Dirk Leuschner, Donald Drake, Chantal Carrez, Paula G. Fraenkel, Erwan Jouannot, Dmitri Wiederschain, Veronique Blanc, Cedric Barriere, Jana Albrecht, Hélène Bonnevaux, Christian Beil, Christian M. Lange, Valérie Bardet, Céline Amara
Publikováno v:
Cancer Research. 78:1785-1785
Acute myeloid leukemia (AML) is characterized by the accumulation of abnormal blast cells in the bone marrow and blood. While high intensity chemotherapy and allogeneic stem cell transplantation cure a subset of patients with AML, many patients are i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f031bf0679db6845f3db9b21197535e1
https://doi.org/10.1158/1538-7445.am2018-1785
https://doi.org/10.1158/1538-7445.am2018-1785
Autor:
Hans-Peter Holzapfel, W. v. Petrykowski, M. Mix, Peter Wonerow, Helmut Willgerodt, Dagmar Führer, Ralf Paschke
Publikováno v:
Experimental and Clinical Endocrinology & Diabetes. 106:S10-S15
Autosomal dominant nonautoimmune hyperthyroidism is a hereditary form of hyperthyroidism caused by constitutively activating germline mutations in the TSH-receptor gene. Clinical features comprise familial prevalence of thyroid autonomy in more than
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::454e44c3177a4e5d2acfd4c2e8c79c83
https://doi.org/10.1055/s-0029-1212049
https://doi.org/10.1055/s-0029-1212049
Publikováno v:
Journal of Biological Chemistry. 278:37520-37529
The interaction of fibrinogen with the integrin alphaIIbbeta3 plays a crucial role in platelet adhesion and platelet activation leading to the generation of intracellular signals that nucleate the reorganization of the cytoskeleton. Presently, we hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58768f7a6b539870accf5fc0d832c1e4
https://doi.org/10.1074/jbc.m305077200
https://doi.org/10.1074/jbc.m305077200
Autor:
Stuart J. MARSHALL, Naoki ASAZUMA, Denise BEST, Peter WONEROW, Gary SALMON, Robert K. ANDREWS, Steve P. WATSON
Publikováno v:
Biochemical Journal. 361:297-305
It has been proposed that the receptor for von Willebrand factor (vWF), glycoprotein (GP)Ib-IX-V, signals through the same pathway as the collagen receptor, GPVI, namely via Src kinases, the Fc receptor (FcR) γ-chain and Syk, leading to tyrosine pho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c0665cc5fb69a3da8e2fd625f66eb681
https://doi.org/10.1042/bj3610297
https://doi.org/10.1042/bj3610297
Autor:
Steve P. Watson, Peter Wonerow
Publikováno v:
Oncogene. 20:6273-6283
The transmembrane adapter LAT (linker for activation of T cells) plays a central role in signalling by ITAM bearing receptors expressed on T cells, natural killer cells, mast cells and platelets. Receptor engagement leads to the phosphorylation of ty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e403af547a7e3b08f4e1a93b2ba444c7
https://doi.org/10.1038/sj.onc.1204770
https://doi.org/10.1038/sj.onc.1204770