Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Peter W. Stengel"'
Publikováno v:
European Journal of Pharmacology. 578:65-75
Previously, we found pulmonary gas trapping to be a rapid, simple and objective measure of methacholine-induced airway obstruction in naive mice. In this study we extended that finding by using methacholine-induced pulmonary gas trapping to different
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a26b418a5dfb489649347462f630006
https://doi.org/10.1016/j.ejphar.2007.08.040
https://doi.org/10.1016/j.ejphar.2007.08.040
Autor:
Peter W. Stengel, Marlene L. Cohen
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 304:675-682
Muscarinic receptors can mediate both contractile and relaxant responses in smooth muscle. The stomach fundus from wild-type mice possesses a neuronal M(1) receptor that mediates relaxation to carbamylcholine and (4-hydroxy-2-butynyl)-1-trimethylammo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67eb2099b7a43739ea47a3c1205e61d5
https://doi.org/10.1124/jpet.102.042283
https://doi.org/10.1124/jpet.102.042283
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 282:R1443-R1449
Negative chronotropic and smooth muscle contractile responses to the nonselective muscarinic agonist carbamylcholine were compared in isolated tissues from M3-muscarinic receptor knockout and wild-type mice. Carbamylcholine (10−8–3.0 × 10−5 M)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87705405425e5bcc3d7e4e0f0a86a6e3
https://doi.org/10.1152/ajpregu.00486.2001
https://doi.org/10.1152/ajpregu.00486.2001
Autor:
Peter W Stengel
Publikováno v:
Journal of Drug Metabolism & Toxicology.
The majority of methods for measuring airway mechanics or pulmonary function in small laboratory animals are labor intensive, require specialized equipment and training, and have a low throughput. Hence, there is a need for a more rapid, simpler, use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06edd9220a11d52c01ac71ac08319956
https://doi.org/10.4172/2157-7609.1000166
https://doi.org/10.4172/2157-7609.1000166
Autor:
Petra A. Carter, Marlene L. Cohen, Frank P. Bymaster, Jürgen Wess, Lu Zhang, Julie F. Falcone, Harlan E. Shannon, Jesus Gomeza, Christian C. Felder, Peter W. Stengel
Publikováno v:
Life Sciences. 68:2473-2479
Determination of muscarinic agonist-induced parasympathomimetic effects in wild type and M2 and M4 muscarinic receptor knockout mice revealed that M2 receptors mediated tremor and hypothermia, but not salivation. The M4 receptors seem to play a modes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d28e4d5271f408216f1c0c955da7d4c2
https://doi.org/10.1016/s0024-3205(01)01041-4
https://doi.org/10.1016/s0024-3205(01)01041-4
Autor:
Jason Scott Sawyer, Michael J. Sofia, Peter W. Stengel, Steven A. Silbaugh, Stephen M. Spaethe, Sandra L. Cockerham, Alison M. Bendele, William T. Jackson, Larry L. Froelich
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 361:397-404
We examined the in vivo actions of LY293111 sodium (2-[2-propyl-3-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]pro poxy]phenoxy] benzoic acid sodium salt). Guinea pigs were used to evaluate the effect of this agent on (1) acute airway obstruction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c838f36c9803f8f50916cc61338f03e9
https://doi.org/10.1007/s002109900211
https://doi.org/10.1007/s002109900211
Publikováno v:
European Journal of Pharmacology. 563:213-215
In asthmatic mice, dexamethasone (30.0 mg/kg) was administered orally once daily on Days 24-27. One hour after dexamethasone on Day 25-27, the mice were exposed to ovalbumin aerosols. Twenty-eight days after the initial ovalbumin immunization, we fou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26934f62c0184b116b3ff3b20639a911
https://doi.org/10.1016/j.ejphar.2007.02.028
https://doi.org/10.1016/j.ejphar.2007.02.028
Publikováno v:
European Journal of Pharmacology. 557:66-68
In guinea pigs, we found that intravenous 5,8,11,14-eicosatetraenamide ( N -2-hydroxyethyl), arachidonylethanolamide (anandamide), 0.3–10.0 mg/kg, did not inhibit leukotriene D 4 (LTD 4 )-induced airway obstruction, while inhaled anandamide, 21.8 a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a67b9e25fa9a6780e5d43b91d1364f79
https://doi.org/10.1016/j.ejphar.2006.11.025
https://doi.org/10.1016/j.ejphar.2006.11.025
Autor:
Steven A. Silbaugh, William A. Devane, Sandra L. Cockerham, Peter W. Stengel, Marian K. Rippy
Publikováno v:
European Journal of Pharmacology. 355:57-66
Anandamide (arachidonylethanolamide), 5,8,11,14-eicosatetraenamide, ( N -2-hydroxyethyl), was tested for bronchodilator and anti-inflammatory activities. Conscious guinea pigs were given cumulative i.v. doses of anandamide (1.0, 3.0, and 10.0 mg/kg)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::918acd1a7ea57efd0177bc02f8356c9e
https://doi.org/10.1016/s0014-2999(98)00472-5
https://doi.org/10.1016/s0014-2999(98)00472-5
Autor:
Lee A. Phebus, Karen Lynn Lobb, Kirk W. Johnson, Peter W. Stengel, Philip Arthur Hipskind, Nixon James Arthur
Publikováno v:
Life Sciences. 60:1553-1561
LY303870 is a competitive, high affinity NK-1 receptor antagonist. It was tested in the trigeminal stimulation-induced neurogenic dural inflammation model of migraine. The neurogenic inflammation theory of migraine pain proposes that substance P, act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e66680407180d6fbd0b4882a425a12e
https://doi.org/10.1016/s0024-3205(97)00121-5
https://doi.org/10.1016/s0024-3205(97)00121-5