Výsledky vyhledávání - "Peter W. Sheldrake"

Conformation Analyses, Dynamic Behavior and Amide Bond Distortions of Medium-sized Heterocycles. 1. Partially and Fully Reduced 1-Benzazepines

Autor: Maryiam Qadir, Peter N. Horton, Andrew J. P. White, Jonathan Cobb, Michael B. Hursthouse, Peter W Sheldrake, King Kuok (Mimi) Hii, Neil Whittall

Publikováno v: The Journal of Organic Chemistry. 70:1545-1551

Five 1-benzazepine heterocycles were synthesized by utilizing transition-metal-catalyzed processes in key bond-forming steps. exo-Methylene and methyl substituents were introduced at position 5, as well as a unit of unsaturation between positions 3 a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dbeff0c1ab1cb82c4763c46ab6e517c
https://doi.org/10.1021/jo048118b

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Synthesis of 2-substituted 1-benzyl-2,3,4,5-tetrahydro-1-benzazepines by palladium catalysis. Observation of a competitive β-hydride elimination pathway

Autor: Thomas Gelbrich, Simon J. Coles, Rachael E. Priestley, Neil Whittall, Maryiam Qadir, Michael B. Hursthouse, Thomas W. D. F. Rising, King Kuok (Mimi) Hii, Peter W. Sheldrake

Publikováno v: Tetrahedron Letters. 44:3675-3678

A synthetic route to 1-benzyl-tetrahydro-1-benzazepine is reported, which also permits access to analogous structures with alkyl and aryl substituents at position-2 of the aliphatic ring. Palladium catalysis is utilized in two of the three steps, con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::369fa38167d5eb2078033b1277a9493a
https://doi.org/10.1016/s0040-4039(03)00676-2

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Biosynthesis. Part 30.1 Colchicine: studies on the ring expansion step focusing on the fate of the hydrogens at C-4 of autumnaline

Autor: Amanda J. Murtagh, Alan C. Barker, Robert N. Woodhouse, Richard B. Herbert, Keith E. Suckling, Alan R. Battersby, James Staunton, Peter W. Sheldrake

Publikováno v: Journal of the Chemical Society, Perkin Transactions 1. :3003-3010

The dienone ring of the intermediate 2 undergoes expansion to form the tropolone nucleus as N-formyldemecolcine 3 and colchicine 4 are biosynthesised. The additional carbon atom needed to form the 7-membered ring is provided by C-12 of the dienone 2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8092e75d583faf63d38f0f41aa7aca28
https://doi.org/10.1039/a803853h

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An efficient method for the synthesis of substituted TosMIC precursors

Autor: Peter W. Sheldrake, Neil H. Baine, Mark Mellinger, Joseph Sisko

Publikováno v: Tetrahedron Letters. 37:8113-8116

Substituted tosylmethyl isocyanides (TosMICs) are useful reagents for which no general method of preparation is available. We describe here a high-yielding method for the synthesis of substituted tosylmethyl formamides, which are readily converted to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ce36e650b3298e351f7ca389f8eb9fbb
https://doi.org/10.1016/0040-4039(96)01886-2

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The Anion of 4-Dimethoxymethylpyridine. A Convenient Synthesis of Some 4-Pyridyl Ketones A convienient synthesis of some 4-pyridyl ketones

Autor: Peter W. Sheldrake

Publikováno v: Synthetic Communications. 23:1967-1971

n-Butyllithium at −78°C abstracts the methine proton from 4-dimethoxymethylpyridine. The anion reacts efficiently with electrophiles. Simple ketal products can be readily hydrolysed to 4-pyridyl ketones.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::19c3c4f837ac7d72824de9142a2fe3ec
https://doi.org/10.1080/00397919308009855

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ChemInform Abstract: Use of Iron(III) Chloride in the Efficient Preparation of the Alkaloid Kreysigine by Oxidative Coupling

Autor: Abdullah E. Kattah, Richard B. Herbert, Amanda J. Murtagh, Peter W. Sheldrake

Publikováno v: ChemInform. 26

Reaction of the isoquinoline (1) with iron (III) chloride in dichloromethane followed by reductive treatment with methanol gives kreysigine (4) in 71% yield; (2) gives (4) in lower yield as does treatment with water instead of methanol; (8) is the pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2078a6acb3ff8b090965a344e47b65b3
https://doi.org/10.1002/chin.199544244

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ChemInform Abstract: An Efficient Method for the Synthesis of Substituted TosMIC Precursors

Autor: Joseph Sisko, Peter W. Sheldrake, Mark Mellinger, Neil H. Baine

Publikováno v: ChemInform. 28

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f44f76137cfe304b0881410ea1fe0e7d
https://doi.org/10.1002/chin.199707114

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