Zobrazeno 1 - 10
of 211
pro vyhledávání: '"Peter W. Ramwell"'
Publikováno v:
Current Opinion in Organ Transplantation. 4:241-247
Publikováno v:
Steroids. 64:472-480
Estradiol-17beta (E2) can inhibit vascular smooth muscle cell (VSMC) proliferation probably through its ability to activate its nuclear estrogen receptors (ER). Activation or inhibition of the ER by cognate permissive or non-permissive ligands, respe
Publikováno v:
Transplantation. 66:1424-1431
BACKGROUND The etiology of transplant arteriosclerosis is unknown, but current data point to the alloimmune response. Previously, we found that estradiol-17beta (E2) with immunosuppressant cyclosporine abolishes major histocompatibility complex (MHC)
Publikováno v:
Circulation Research. 83:947-951
Abstract —Estrogen receptor (ER) expression has been detected in different tissues, and estradiol-17β treatment protects against experimental transplant arteriosclerosis. In this study, ER-α expression in the rabbit hearts and attached aortas bef
Autor:
Adam K. Myers, Alfonso M. Pacquing, Peter W. Ramwell, David Eric Lees, M Y Farhat, Kerry W. DeGroot, Young D. Kim, Johan P. Suyderhoud, Peter C. Kouretas
Publikováno v:
Journal of Cardiovascular Pharmacology. 32:457-465
We studied the effect of 2-week treatment with estradiol 17beta on myocardial glutathione concentration in dogs and isolated perfused rat heart subjected to brief coronary ischemia and reperfusion. Estradiol protected against ischemia/reperfusion-ind
Publikováno v:
Transplantation. 66:419-426
BACKGROUND A crucial step in cell cycle progression is the activation of the insulin-like growth factor I (IGF-I) receptor (IGF-IR) by its ligand. Earlier, we found estradiol 17-beta treatment of cardiac allograft recipients attenuates transplant art
Publikováno v:
Transplantation Reviews. 12:96-109
Summary The cause of chronic rejection is clearly multifactorial and relates to both immunologic and nonimmunologic factors. Most likely, the final effector molecules are the growth factors expressed, in response to immune injury, by endothelial and
Publikováno v:
Transplantation. 65:1024-1030
BACKGROUND Accelerated arteriosclerosis limits the survival of transplanted hearts. We hypothesized that insulin-like growth factor-I (IGF-I) is crucial in accelerating transplant arteriosclerosis. Recently, we reported that exposure to IGF-I prior t
Publikováno v:
The Journal of Thoracic and Cardiovascular Surgery. 114:803-810
Objective: Transplant arteriosclerosis is the major determinant for long-term survival of cardiac transplants. Estradiol treatment inhibits transplant arteriosclerosis. The objective of this study is to determine, in the absence of immunosuppression,
Publikováno v:
Transplantation Proceedings. 29:2605-2608