Výsledky vyhledávání - "Peter W. Mesner"

Moderate Hyperthermia Induces Apoptosis in Metaphase-Arrested Cells But Not in Interphase Hela Cells

Autor: James R. Paulson, Agnes Kecskeméti Kresch, Peter W. Mesner

Publikováno v: Advances in Biological Chemistry. :126-139

Metaphase-arrest agents and hyperthermia are both known to be capable of inducing apoptosis, and they have been used, separately, in cancer treatments. Here, we have examined whether the two treatments together may have a synergistic effect. We find

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8098651f72823f162a25d03b0050ff22
https://doi.org/10.4236/abc.2016.63011

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Evaluation of Apaf-1 and procaspases-2, -3, -7, -8, and -9 as potential prognostic markers in acute leukemia

Autor: Steven D. Gore, John C. Reed, Philip J. Burke, Stan Krajewski, Yuri Lazebnik, Scott H. Kaufmann, Judith E. Karp, Peter W. Mesner, Phyllis A. Svingen

Publikováno v: Blood. 96:3922-3931

Recent studies have suggested that variations in levels of caspases, a family of intracellular cysteine proteases, can profoundly affect the ability of cells to undergo apoptosis. In this study, immunoblotting was used to examine levels of apoptotic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dd8027913e6869f60e1a0bc20d48980
https://doi.org/10.1182/blood.v96.12.3922.h8003922_3922_3931

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Characterization of Caspase Processing and Activation in HL-60 Cell Cytosol Under Cell-free Conditions

Autor: Scott H. Kaufmann, Phyllis A. Svingen, John C. Reed, Srinivasa M. Srinivasula, Tamie J. Chilcote, Timothy Kottke, Emad S. Alnemri, Stan Krajewski, Guriq S. Basi, Keith C. Bible, Peter W. Mesner, William C. Earnshaw, Jay S. Tung, Luis M. Martins

Publikováno v: Journal of Biological Chemistry. 274:22635-22645

The present studies compared caspase activation under cell-free conditions in vitro and in etoposide-treated HL-60 leukemia cells in situ. Immunoblotting revealed that incubation of HL-60 cytosol at 30 degrees C in the presence of cytochrome c and AT

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5ad15d8115855898bb13b2d3af9eb6d5
https://doi.org/10.1074/jbc.274.32.22635

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Comparison of Paclitaxel-, 5-Fluoro-2′-deoxyuridine-, and Epidermal Growth Factor (EGF)-induced Apoptosis

Autor: Timothy Kottke, Deborah K. Armstrong, April L. Blajeski, Scott H. Kaufmann, Nancy E. Davidson, L. Miguel Martins, Peter W. Mesner, William C. Earnshaw

Publikováno v: Journal of Biological Chemistry. 274:15927-15936

Epidermal growth factor (EGF), a hormone that stimulates proliferation of many cell types, induces apoptosis in some cell lines that overexpress the EGF receptor. To evaluate the mechanism of EGF-induced apoptosis, MDA-MB-468 breast cancer cells were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2e33c784999f0ff491d96051cacd38c1
https://doi.org/10.1074/jbc.274.22.15927

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Caspases Mediate Tumor Necrosis Factor-–Induced Neutrophil Apoptosis and Downregulation of Reactive Oxygen Production

Autor: Shin Yonehara, Kokichi Yamamoto, Hirokazu Hirata, Atsushi Takahashi, Takashi Uchiyama, Susumu Kobayashi, Kouhei Yamashita, Peter W. Mesner, Scott H. Kaufmann, Masataka Sasada

Publikováno v: Blood. 93:674-685

Tumor necrosis factor- (TNF-) exerts two separate effects on neutrophils, stimulating effector functions while simultaneously inducing apoptosis. We examined here the involvement of caspases in neutrophil apoptosis and the effect of TNF-–i

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https://doi.org/10.1182/blood.v93.2.674.402k26_674_685

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Comparison of Caspase Activation and Subcellular Localization in HL-60 and K562 Cells Undergoing Etoposide-Induced Apoptosis

Autor: Daniel J. McCormick, Timothy Kottke, Guriqbal S. Basi, Jay S. Tung, Peter W. Mesner, Scott H. Kaufmann, Benjamin J. Madden, William C. Earnshaw, Phyllis A. Svingen, Atsushi Takahashi, Luis M. Martins, Sukanto Sinha

Publikováno v: Blood. 90:4283-4296

Previous studies have shown that K562 chronic myelogenous leukemia cells are resistant to induction of apoptosis by a variety of agents, including the topoisomerase II (topo II) poison etoposide, when examined 4 to 24 hours after treatment with an in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7ae7d35911c8ab3d98d8b497da4e3593
https://doi.org/10.1182/blood.v90.11.4283.4283_4283_4296

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Comparison of Caspase Activation and Subcellular Localization in HL-60 and K562 Cells Undergoing Etoposide-Induced Apoptosis

Autor: Luis M. Martins, Peter W. Mesner, Timothy J. Kottke, Guriqbal S. Basi, Sukanto Sinha, Jay S. Tung, Phyllis A. Svingen, Benjamin J. Madden, Atsushi Takahashi, Daniel J. McCormick, William C. Earnshaw, Scott H. Kaufmann

Publikováno v: Blood. 90:4283-4296

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a0418b831720e2dc88053f7fed55b1ce
https://doi.org/10.1182/blood.v90.11.4283

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Affinity labeling displays the stepwise activation of ICE-related proteases by Fas, staurosporine, and CrmA-sensitive caspase-8

Autor: Richard W. Moyer, Hirokazu Hirata, Kokichi Yamamoto, Toshiro Okazaki, Hirofumi Sawai, Shuji Kishi, Peter W. Mesner, Kyung-Kwon Lee, Minoru Okuma, Shin Yonehara, Masataka Sasada, Atsushi Takahashi, Peter C. Turner, Yuzuru Imai

Publikováno v: Oncogene. 14:2741-2752

The activation of multiple interleukin-1beta converting enzyme-related proteases (caspases) in apoptotic mammalian cells raises questions as to whether the multiple active caspases have distinct roles in apoptotic execution as well as how these prote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5c1b0632339b43c3f6e19c5feaf895a
https://doi.org/10.1038/sj.onc.1201131

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A timetable of events during programmed cell death induced by trophic factor withdrawal from neuronal PC12 cells

Autor: Peter W. Mesner, Conrad L. Epting, Steven H. Green, Joseph L. Hegarty

Publikováno v: The Journal of Neuroscience. 15:7357-7366

We describe a timetable of events during programmed cell death (PCD) in neuronal PC12 cells, specifically, Ras signaling, immediate-early gene (IEG) expression, DNA fragmentation and commitment to PCD. Commitment occurs over a period from 10–20 hr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78b363299dfff468a7901206844221ce
https://doi.org/10.1523/jneurosci.15-11-07357.1995

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Seasonal testosterone levels in leydig and sertoli cells of the snapping turtle (Chelydra serpentina) in natural populations

Autor: Peter W. Mesner, Ibrahim Y. Mahmoud, Rodney V. Cyrus

Publikováno v: Journal of Experimental Zoology. 266:266-276

Leydig cells were enzymatically separated from the seminiferous tubules and were then purified by isoosmotic Percoll gradient centrifugation so that steroidogenic activity in the two sites could be measured separately. After purification, the cells i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::da80844ac46f1c117e99c818e1a84960
https://doi.org/10.1002/jez.1402660404

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