Zobrazeno 1 - 10
of 152
pro vyhledávání: '"Peter W. Mason"'
Autor:
Peter W. Mason, Clayton W. Beard, Lesley C. Dupuy, Jeffrey B. Ulmer, Dong Yu, Carolyn M. Six, Andrew Geall, Connie S. Schmaljohn, Marcelo M. Samsa
Publikováno v:
Molecular Therapy. 27:850-865
Venezuelan equine encephalitis virus (VEEV) is a known biological defense threat. A live-attenuated investigational vaccine, TC-83, is available, but it has a high non-response rate and can also cause severe reactogenicity. We generated two novel VEE
Autor:
Luana de Borba, Daisy M Strottmann, Lucia de Noronha, Peter W Mason, Claudia N Duarte Dos Santos
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 6, Iss 4, p e1624 (2012)
BACKGROUND: Dengue includes a broad range of symptoms, ranging from fever to hemorrhagic fever and may occasionally have alternative clinical presentations. Many possible viral genetic determinants of the intrinsic virulence of dengue virus (DENV) in
Externí odkaz:
https://doaj.org/article/a606f317c8fb462faa37f80922e79ac9
Autor:
Andrew B. Ward, Christos A. Kyratsous, Ricardo Carrion, Gabriella Worwa, William D. Pratt, Gang Chen, William C. Olson, Terra Potocky, Joel H. Martin, Karl J. Erlandson, John C. Trefry, Ashique Rafique, Peter W. Mason, Hilary M. Staples, Tammy T. Huang, Hannah L. Turner, Robert Babb, Drew Dudgeon, Leah Lipsich, Joshua D. Shamblin, Ying Yan, Yasuteru Sakurai, Thomas M Dreier, Manu Anantpadma, Kevin Yu, Marcela Torres, Sandra L. Bixler, Suzanne E. Wollen, Charles D. Murin, Neil Stahl, Justine M. Zelko, Melissa S Willis, Robert A. Davey, Darya Burakov, Jeanette L. Fairhurst, Ashok Badithe, Margaret L. Pitt, Franco Rossi, Taylor B. Chance, Kimberly Armstrong, Kristen E. Pascal
Publikováno v:
The Journal of Infectious Diseases
Background For most classes of drugs, rapid development of therapeutics to treat emerging infections is challenged by the timelines needed to identify compounds with the desired efficacy, safety, and pharmacokinetic profiles. Fully human monoclonal a
Autor:
Diletta Magini, Sylvie Bertholet, Alessandra Bonci, Peter W. Mason, Scilla Buccato, Simona Mangiavacchi, Ennio De Gregorio, Andrew Geall, Jeffrey B. Ulmer, Michela Brazzoli, Roland Kratzer, Vanessa Zurli, Cinzia Giovani, Luis Brito, Daniele Casini
Publikováno v:
Journal of Virology. 90:332-344
Seasonal influenza is a vaccine-preventable disease that remains a major health problem worldwide, especially in immunocompromised populations. The impact of influenza disease is even greater when strains drift, and influenza pandemics can result whe
Autor:
Christina D. Smolke, Peter W. Mason, Dong Yu, Clayton W. Beard, Andrew Geall, Christie L. Bell
Publikováno v:
Virology. 483:302-311
Alphavirus-based replicons are a promising nucleic acid vaccine platform characterized by robust gene expression and immune responses. To further explore their use in vaccination, replicons were engineered to allow conditional control over their gene
Autor:
Nico van Rooijen, Nigel Bourne, Jingya Xia, Douglas G. Widman, Evandro R. Winkelmann, Gregg N. Milligan, Alison J. Johnson, Peter W. Mason
Publikováno v:
Virology, 450, 278-289. Academic Press Inc.
Winkelmann, E R, Widman, D G, Xia, J, Johnson, A J, van Rooijen, N, Mason, P W, Bourne, N & Milligan, G N 2014, ' Subcapsular sinus macrophages limit dissemination of West Nile virus particles after inoculation but are not essential for the development of West Nile virus-specific T cell responses ', Virology, vol. 450, pp. 278-289 . https://doi.org/10.1016/j.virol.2013.12.021
Winkelmann, E R, Widman, D G, Xia, J, Johnson, A J, van Rooijen, N, Mason, P W, Bourne, N & Milligan, G N 2014, ' Subcapsular sinus macrophages limit dissemination of West Nile virus particles after inoculation but are not essential for the development of West Nile virus-specific T cell responses ', Virology, vol. 450, pp. 278-289 . https://doi.org/10.1016/j.virol.2013.12.021
Macrophages encounter flaviviruses early after injection by arthropod vectors. Using in vivo imaging of mice inoculated with firefly luciferase-expressing single-cycle flavivirus particles (FLUC-SCFV), we examined the initial dissemination of virus p
Publikováno v:
Journal of Virology. 87:12090-12101
Recognition of conserved pathogen-associated molecular patterns (PAMPs) by host pattern recognition receptors (PRRs) results in the activation of innate signaling pathways that drive the innate immune response and ultimately shape the adaptive immune
Autor:
Terika Spencer, Peter W. Mason, Angelica Medina-Selby, Sumana Chandramouli, Ethan C. Settembre, Christian W. Mandl, Doris Coit, Luis Brito, Gillis R. Otten, Mary Schaefer, Philip R. Dormitzer, Pu Zhang
Publikováno v:
Vaccine. 31:3872-3878
Parvovirus B19 is the causative agent of fifth disease in children, aplastic crisis in those with blood dyscrasias, and hydrops fetalis. Previous parvovirus B19 virus-like-particle (VLP) vaccine candidates were produced by co-infection of insect cell
Autor:
Peter W. Mason, Anders Lilja
Publikováno v:
Vaccine. 30:6980-6990
Human cytomegalovirus (HCMV) infects the majority of the global population and persists within the infected host for life; infection of healthy adults rarely leads to severe acute clinical symptoms. In contrast, HCMV is a leading infectious cause of
Autor:
Jingya Xia, Evandro R. Winkelmann, Tomohiro Ishikawa, Michelle H. Nelson, Peter W. Mason, Mindy Miller-Kittrell, Nigel Bourne, Frank Scholle, Douglas G. Widman, Gregg N. Milligan
Publikováno v:
Vaccine. 30:1465-1475
Type I interferons (IFNs) are critical for controlling pathogenic virus infections and can enhance immune responses. Hence their impact on the effectiveness of live-attenuated vaccines involves a balance between limiting viral antigen expression and