Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Peter W. Hairsine"'
Autor:
Fred L. Parker, Ian R. Ager, Peter J. Miller, Anne B. Doyle, Peter W. Hairsine, Keith P. McDonald
Publikováno v:
Drug Development Research. 22:349-361
The kinetics of imidazopyrimidines selected for development were investigated in the rat, dog, and cynomolgus monkey using high pressure liquid chromatography (HPLC) measurements of levels. These data were compared with levels estimated by benzodiaze
Autor:
C. B. Jones, E. A. Kuo, Yea Christopher Martyn, C. J. R. Hedgecock, Peter W. Hairsine, N. Mcdowall, R. A. Williamson, P. Hambleton, W. R. Tully, Robert Westwood, Saroop S. Matharu, Ian R. Ager, David Kay, A. W. E. Chan, P. L. Evans, E. Little
Publikováno v:
Journal of medicinal chemistry. 39(23)
The active metabolite (2) of the novel immunosuppressive agent leflunomide (1) has been shown to inhibit the enzyme dihydroorotate dehydrogenase (DHODH). This enzyme catalyzes the fourth step in de novo pyrimidine biosynthesis. A series of analogues
Publikováno v:
Journal of Medicinal Chemistry. 22:418-424
The antiallergic activity of some xanthone derivatives containing a sulfoximide substitutent has been investigated. While 2-(S-methylsulfonimidoyl)xanthone itself was found to be inactive, a series of 7-(S-methylsulfonimidoly)-xanthone-2-carboxylic a
Publikováno v:
Journal of Heterocyclic Chemistry. 16:1089-1091
5-Hexyl-7-(S-methylsulfonimidoyl)xanthone-2-carboxylic acid 1a, when heated above its melting point gives a number of products including the corresponding methyl ester 1b, which arises by a novel methyl group transfer. A similar methyl transfer react
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 1. :1049
A novel synthesis of the new 4H-imidazo[2,1-c][1,4]benzoxazine system (2) has been carried out under two sets of conditions, leading to products with differing functionalities. The effect of substituents on the cyclization step has been investigated