Zobrazeno 1 - 10 of 35 pro vyhledávání: '"Peter W. Flatman"'
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Akademický článek
Renal and Blood Pressure Response to a High-Salt Diet in Mice With Reduced Global Expression of the Glucocorticoid Receptor
Autor: Jessica R. Ivy, Louise C. Evans, Rebecca Moorhouse, Rachel V. Richardson, Emad A. S. Al-Dujaili, Peter W. Flatman, Christopher J. Kenyon, Karen E. Chapman, Matthew A. Bailey
Publikováno v: Frontiers in Physiology, Vol 9 (2018)
Salt-sensitive hypertension is common in glucocorticoid excess. Glucocorticoid resistance also presents with hypercortisolemia and hypertension but the relationship between salt intake and blood pressure (BP) is not well defined. GRβgeo/+ mice have
Externí odkaz: https://doaj.org/article/2c0e2c5eb9cb4c6c85491957ffa6e03f
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2
Glucocorticoid receptor activation stimulates the sodium-chloride cotransporter and influences the diurnal rhythm of its phosphorylation
Autor: Jessica R. Ivy, Natalie K. Jones, Theresa S. Peltz, Hannah M. Costello, Peter W. Flatman, Morag K. Mansley, Matthew A. Bailey
Publikováno v: Ivy, J R, Jones, N, Costello, H, Mansley, M K, Peltz, T S, Flatman, P & Bailey, M A 2019, ' Glucocorticoid receptor activation stimulates the Na-Cl co-transporter and influences the diurnal rhythm of its phosphorylation ', American Journal of Physiology-Renal Physiology, vol. 317, no. 6, pp. F1536-F1548 . https://doi.org/10.1152/ajprenal.00372.2019
American Journal of Physiology-Renal Physiology
The sodium-chloride cotransporter (NCC) in the distal convoluted tubule contributes importantly to sodium balance and blood pressure (BP) regulation. NCC phosphorylation determines transport activity and has a diurnal rhythm influenced by glucocortic
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b7157c2e2de42cb0004a24568c94107
https://doi.org/10.1152/ajprenal.00372.2019
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3
Hypertrophy in the Distal Convoluted Tubule of an 11β-Hydroxysteroid Dehydrogenase Type 2 Knockout Model
Autor: Jessica R. Ivy, Peter W. Flatman, Christopher J Kenyon, Eilidh Craigie, Matthew A. Bailey, Robert W. Hunter, Linda J. Mullins, John J. Mullins
Publikováno v: Journal of the American Society of Nephrology. 26:1537-1548
Na(+) transport in the renal distal convoluted tubule (DCT) by the thiazide-sensitive NaCl cotransporter (NCC) is a major determinant of total body Na(+) and BP. NCC-mediated transport is stimulated by aldosterone, the dominant regulator of chronic N
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::090c7dff475697f9be655de11f5a4b17
https://doi.org/10.1681/asn.2013060634
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4
Functional Expression of the Na-K-2Cl Cotransporter NKCC2 in Mammalian Cells Fails to Confirm the Dominant-negative Effect of the AF Splice Variant*
Autor: Peter W. Flatman, Jenny K. Christie, Anke Hannemann
Publikováno v: The Journal of Biological Chemistry
Hannemann, A, Christie, J K & Flatman, P W 2009, ' Functional Expression of the Na-K-2Cl Cotransporter NKCC2 in Mammalian Cells Fails to Confirm the Dominant-negative Effect of the AF Splice Variant ', Journal of Biological Chemistry, vol. 284, no. 51, pp. 35348-35358 . https://doi.org/10.1074/jbc.M109.060004
The renal bumetanide-sensitive Na-K-2Cl cotransporter (NKCC2) is the major salt transport pathway in the apical membrane of the mammalian thick ascending limb. It is differentially spliced and the three major variants (A, B, and F) differ in their lo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1d916ad53ec851237a12737ae426606
http://europepmc.org/articles/PMC2790964
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5
Cotransporters, WNKs and hypertension: important leads from the study of monogenetic disorders of blood pressure regulation
Autor: Peter W. Flatman
Publikováno v: Clinical Science. 112:203-216
Major advances are being made in identifying the structure and behaviour of regulatory cascades that control the activity of cation–Cl− cotransporters and certain Na+, K+ and Cl− channels. These transporters play key roles in regulating arteria
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc32d33bbefa46a2ef79c922748ae0cf
https://doi.org/10.1042/cs20060225
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7
Changes in protein expression in the rat medial vestibular nuclei during vestibular compensation
Autor: Duncan Short, Alastair Aitken, Peter W. Flatman, Janet M. Paterson, Mayank B. Dutia, Jonathan R. Seckl
Publikováno v: The Journal of Physiology. 575:777-788
The molecular mechanisms of neural and synaptic plasticity in the vestibular nuclei during ‘vestibular compensation’, the behavioural recovery that follows deafferentation of one inner ear, are largely unknown. In this study we have used differen
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bb06d7caa7ba362f3d2513b95fa43c93
https://doi.org/10.1113/jphysiol.2006.112409
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8
Loading rat heart myocytes with Mg2+using low-[Na+] solutions
Autor: Peter W. Flatman, Michael G. Steele, Peter G. Bush, Hasan A. Almulla, David Ellis
Publikováno v: The Journal of Physiology. 575:443-454
The objective of our study was to investigate how Mg2+ enters mammalian cardiac cells. During this work, we found evidence for a previously undescribed route for Mg2+ entry, and now provide a preliminary account of its properties. Changes in Mg2+ inf
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b4d89a0a280662889b4cd26b1efda456
https://doi.org/10.1113/jphysiol.2006.109850
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9
Activation of ferret erythrocyte Na+-K+-2Cl−cotransport by deoxygenation
Autor: Peter W. Flatman
Publikováno v: The Journal of Physiology. 563:421-431
Deoxygenation of ferret erythrocytes stimulates Na+–K+–2Cl− cotransport by 111% (s.d., 46) compared to controls in air. Half-maximal activation occurs at a PO2 of 24 mmHg (s.d., 2) indicating that physiological changes in oxygen tension can inf
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9ce5b41d04768f551a0543a876bad701
https://doi.org/10.1113/jphysiol.2004.080507
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10
Regulation of Na–K–2Cl cotransport by phosphorylation and protein–protein interactions
Autor: Peter W. Flatman
Publikováno v: Biochimica et Biophysica Acta (BBA) - Biomembranes. 1566:140-151
The Na–K–2Cl cotransporter plays important roles in cell ion homeostasis and volume control and is particularly important in mediating the movement of ions and thus water across epithelia. In addition to being affected by the concentration of the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::541c8ba34e9c6bc89b6f23067cbab694
https://doi.org/10.1016/s0005-2736(02)00586-2
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