Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Peter W Reddien"'
Autor:
Melanie Issigonis, Akshada B Redkar, Tania Rozario, Umair W Khan, Rosa Mejia-Sanchez, Sylvain W Lapan, Peter W Reddien, Phillip A Newmark
Publikováno v:
PLoS Biology, Vol 20, Iss 7, p e3001472 (2022)
Sexually reproducing animals segregate their germline from their soma. In addition to gamete-producing gonads, planarian and parasitic flatworm reproduction relies on yolk cell-generating accessory reproductive organs (vitellaria) supporting developm
Externí odkaz:
https://doaj.org/article/b782261626db44e78acdf304854ec834
Publikováno v:
PLoS Genetics, Vol 17, Iss 3, p e1009466 (2021)
Planarians are flatworms and can perform whole-body regeneration. This ability involves a mechanism to distinguish between anterior-facing wounds that require head regeneration and posterior-facing wounds that require tail regeneration. How this head
Externí odkaz:
https://doaj.org/article/123d26313eb5410fb3ef05a734fa755c
Publikováno v:
PLoS Genetics, Vol 15, Iss 10, p e1008401 (2019)
Wnt signaling regulates primary body axis formation across the Metazoa, with high Wnt signaling specifying posterior identity. Whether a common Wnt-driven transcriptional program accomplishes this broad role is poorly understood. We identified genes
Externí odkaz:
https://doaj.org/article/cfc18502f55840b1829b584fc11a6dd4
Publikováno v:
eLife, Vol 8 (2019)
Positional information is fundamental to animal regeneration and tissue turnover. In planarians, muscle cells express signaling molecules to promote positional identity. At the ends of the anterior-posterior (AP) axis, positional identity is determin
Externí odkaz:
https://doaj.org/article/18fea7a15f624979b8c026e1cd4426a5
Autor:
Michelle A Carmell, Gregoriy A Dokshin, Helen Skaletsky, Yueh-Chiang Hu, Josien C van Wolfswinkel, Kyomi J Igarashi, Daniel W Bellott, Michael Nefedov, Peter W Reddien, George C Enders, Vladimir N Uversky, Craig C Mello, David C Page
Publikováno v:
eLife, Vol 5 (2016)
The advent of sexual reproduction and the evolution of a dedicated germline in multicellular organisms are critical landmarks in eukaryotic evolution. We report an ancient family of GCNA (germ cell nuclear antigen) proteins that arose in the earliest
Externí odkaz:
https://doaj.org/article/bb2777a7496b45ab8f0371093ab6a3f1
Publikováno v:
eLife, Vol 5 (2016)
Hedgehog signaling is critical for vertebrate central nervous system (CNS) development, but its role in CNS biology in other organisms is poorly characterized. In the planarian Schmidtea mediterranea, hedgehog (hh) is expressed in medial cephalic gan
Externí odkaz:
https://doaj.org/article/87c98ee316ec432c96a73497b0fcf19e
Publikováno v:
eLife, Vol 5 (2016)
How positional information instructs adult tissue maintenance is poorly understood. Planarians undergo whole-body regeneration and tissue turnover, providing a model for adult positional information studies. Genes encoding secreted and transmembrane
Externí odkaz:
https://doaj.org/article/5d3a17595ed8470ca058878c14d72235
Publikováno v:
PLoS Genetics, Vol 10, Iss 1, p e1003999 (2014)
Planarian regeneration requires positional information to specify the identity of tissues to be replaced as well as pluripotent neoblasts capable of differentiating into new cell types. We found that wounding elicits rapid expression of a gene encodi
Externí odkaz:
https://doaj.org/article/0de535a53004446cb8cdce7534aa2879
Publikováno v:
eLife, Vol 2 (2013)
Regeneration is widespread, but mechanisms that activate regeneration remain mysterious. Planarians are capable of whole-body regeneration and mount distinct molecular responses to wounds that result in tissue absence and those that do not. A major q
Externí odkaz:
https://doaj.org/article/e357410d5add473c9f580eacd4b00b80
Autor:
Sylvain W Lapan, Peter W Reddien
Publikováno v:
PLoS Genetics, Vol 7, Iss 8, p e1002226 (2011)
Optic cups are a structural feature of diverse eyes, from simple pit eyes to camera eyes of vertebrates and cephalopods. We used the planarian prototypic eye as a model to study the genetic control of optic cup formation and regeneration. We identifi
Externí odkaz:
https://doaj.org/article/3be544472ef842ce9558dc89c32c0d54