Zobrazeno 1 - 10
of 173
pro vyhledávání: '"Peter W Mathieson"'
Autor:
Xiqian Lan, Partab Rai, Nirupama Chandel, Kang Cheng, Rivka Lederman, Moin A Saleem, Peter W Mathieson, Mohammad Husain, John T Crosson, Kalpna Gupta, Ashwani Malhotra, Pravin C Singhal
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e55748 (2013)
Morphine has been reported to accelerate the progression of chronic kidney disease. However, whether morphine affects slit diaphragm (SD), the major constituent of glomerular filtration barrier, is still unclear. In the present study, we examined the
Externí odkaz:
https://doaj.org/article/58f10f5c3ef1429cb4a2635bcdbe0a2d
Autor:
Anurag Singh, Raina D Ramnath, Rebecca R Foster, Emma C Wylie, Vincent Fridén, Ishita Dasgupta, Borje Haraldsson, Gavin I Welsh, Peter W Mathieson, Simon C Satchell
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e55852 (2013)
Reactive oxygen species (ROS) play a key role in the pathogenesis of proteinuria in glomerular diseases like diabetic nephropathy. Glomerular endothelial cell (GEnC) glycocalyx covers the luminal aspect of the glomerular capillary wall and makes an i
Externí odkaz:
https://doaj.org/article/e52a8bf16aad419c8cdf3553c65726ed
Autor:
Claire Rigothier, Patrick Auguste, Gavin I Welsh, Sébastien Lepreux, Colette Deminière, Peter W Mathieson, Moin A Saleem, Jean Ripoche, Christian Combe
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e37695 (2012)
IQGAP1 is a scaffold protein that interacts with proteins of the cytoskeleton and the intercellular adhesion complex. In podocytes, IQGAP1 is associated with nephrin in the glomerular slit diaphragm (SD) complex, but its role remains ill-defined. In
Externí odkaz:
https://doaj.org/article/ff2458d3cafa4b1f939990839a289e63
Autor:
Thaneas Prabakaran, Rikke Nielsen, Simon C Satchell, Peter W Mathieson, Ulla Feldt-Rasmussen, Søren S Sørensen, Erik I Christensen
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e39975 (2012)
Prominent vasculopathy in Fabry disease patients is caused by excessive intracellular accumulation of globotriaosylceramide (GL-3) throughout the vascular endothelial cells causing progressive cerebrovascular, cardiac and renal impairments. The vascu
Externí odkaz:
https://doaj.org/article/9466320645a544d28b7ef843124789d0
Autor:
Sadie C Slater, Vince Beachley, Thomas Hayes, Daming Zhang, Gavin I Welsh, Moin A Saleem, Peter W Mathieson, Xuejun Wen, Bo Su, Simon C Satchell
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e20802 (2011)
The filtering unit of the kidney, the glomerulus, contains capillaries whose walls function as a biological sieve, the glomerular filtration barrier. This comprises layers of two specialised cells, glomerular endothelial cells (GEnC) and podocytes, s
Externí odkaz:
https://doaj.org/article/0dbab7e3d6a14be998f4fc9d45c15212
Autor:
David O. Bates, Monica Gamez, Andrew H.J. Salmon, Sara Desideri, Simon C. Satchell, Benjamin P. Dallyn, Siân L. Baker, Raina D. Ramnath, Peter W. Mathieson, Gavin I. Welsh, Louise K. Farmer, Nicola Buckner, Christopher R. Neal, Rebecca R. Foster, Karen L. Onions, Luigi Gnudi, Kai B. Betteridge, Kari Alitalo
Publikováno v:
Onions, K L, Gamez, M, Buckner, N R, Baker, S L, Betteridge, K B, Desideri, S, Dallyn, B P, Ramnath, R D, Neal, C R, Farmer, L K, Mathieson, P W, Gnudi, L, Alitalo, K, Bates, D O, Salmon, A H J, Welsh, G I, Satchell, S C & Foster, R R 2019, ' VEGFC reduces glomerular albumin permeability and protects against alterations in VEGF receptor expression in diabetic nephropathy ', Diabetes, vol. 68, no. 1, pp. 172-187 . https://doi.org/10.2337/db18-0045
Onions, K, Gamez, M, Buckner, N R, Baker, S L, Betteridge, K B, Desideri, S, Dallyn, B P, Ramnath, R, Neal, C R, Farmer, L K, Mathieson, P W, Gnudi, L, Alitalo, K, Bates, D O, Salmon, A H J, Welsh, G I, Satchell, S C & Foster, R R 2019, ' VEGFC reduces glomerular albumin permeability and protects against alterations in VEGF receptor expression in diabetic nephropathy ', Diabetes, vol. 68, no. 1, pp. 172-187 . https://doi.org/10.2337/db18-0045
Onions, K, Gamez, M, Buckner, N R, Baker, S L, Betteridge, K B, Desideri, S, Dallyn, B P, Ramnath, R, Neal, C R, Farmer, L K, Mathieson, P W, Gnudi, L, Alitalo, K, Bates, D O, Salmon, A H J, Welsh, G I, Satchell, S C & Foster, R R 2019, ' VEGFC reduces glomerular albumin permeability and protects against alterations in VEGF receptor expression in diabetic nephropathy ', Diabetes, vol. 68, no. 1, pp. 172-187 . https://doi.org/10.2337/db18-0045
Elevated levels of vascular endothelial growth factor (VEGF) A are thought to cause glomerular endothelial cell (GEnC) dysfunction and albuminuria in diabetic nephropathy. We hypothesized that VEGFC could counteract these effects of VEGFA to protect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c39bf793bc204a86d876d372fe64aec
https://doi.org/10.2337/db18-0045
https://doi.org/10.2337/db18-0045
Autor:
Olivia May, Nicolas S. Merle, Anne Grunenwald, Viviane Gnemmi, Juliette Leon, Cloé Payet, Tania Robe-Rybkine, Romain Paule, Florian Delguste, Simon C. Satchell, Peter W. Mathieson, Marc Hazzan, Eric Boulanger, Jordan D. Dimitrov, Veronique Fremeaux-Bacchi, Marie Frimat, Lubka T. Roumenina
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Atypical hemolytic uremic syndrome (aHUS) is a severe disease characterized by microvascular endothelial cell (EC) lesions leading to thrombi formation, mechanical hemolysis and organ failure, predominantly renal. Complement system overactivation is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doajarticles::56d9bda4c2586ea1e90a9aac6ba60fa3
https://www.frontiersin.org/article/10.3389/fimmu.2018.03008/full
https://www.frontiersin.org/article/10.3389/fimmu.2018.03008/full
Autor:
Matthias Kretzler, Barry I. Freedman, James A. Snipes, Mariana Murea, Dongmei Cheng, Gregory S. Shelness, Snezana Petrovic, Simon C. Satchell, Bernhard Banas, Allison Weckerle, Michael D. Ross, Lijun Ma, Martin R. Pollak, Moin A. Saleem, Lawrence L. Rudel, Peter W. Mathieson, Peter A. Antinozzi, Ashok K. Hemal, John S. Parks
Publikováno v:
Journal of the American Society of Nephrology. 26:339-348
Although APOL1 gene variants are associated with nephropathy in African Americans, little is known about APOL1 protein synthesis, uptake, and localization in kidney cells. To address these questions, we examined APOL1 protein and mRNA localization in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82834445b52eda017818122de751c9c0
https://doi.org/10.1681/asn.2013091017
https://doi.org/10.1681/asn.2013091017
Autor:
Gavin I. Welsh, Anurag Singh, Dickson W.L. Wong, L Armstrong, Raina D. Ramnath, Robert Steadman, Simon C. Satchell, Emma C. Wylie, Rebecca R. Foster, Siân L. Baker, Peter W. Mathieson, Robert Leyshon Jenkins
Publikováno v:
The American Journal of Pathology. 183:604-616
Damage to endothelial glycocalyx impairs vascular barrier function and may contribute to progression of chronic vascular disease. An early indicator is microalbuminuria resulting from glomerular filtration barrier damage. We investigated the contribu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f565c882308fc418bb913b1aafe9bd80
https://doi.org/10.1016/j.ajpath.2013.04.019
https://doi.org/10.1016/j.ajpath.2013.04.019
Autor:
Peter W. Mathieson, Andrei Plagov, Pravin C. Singhal, Moin A. Saleem, Tejinder Singh, Xiqian Lan, Rivka Lederman, Nirupama Chandel, Ashwani Malhotra, Partab Rai, Kamesh Ayasolla, Mohammad Husain, Praveen N. Chander
Publikováno v:
American Journal of Physiology-Renal Physiology. 305:F343-F354
Oxidative stress has been implicated to contribute to HIV-induced kidney cell injury; however, the role of p53, a modulator of oxidative stress, has not been evaluated in the development of HIV-associated nephropathy (HIVAN). We hypothesized that mam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e47eeb78079ff7223b81f5f270b3a14e
https://doi.org/10.1152/ajprenal.00135.2013
https://doi.org/10.1152/ajprenal.00135.2013