Zobrazeno 1 - 10
of 152
pro vyhledávání: '"Peter Würtz"'
Autor:
Heli Julkunen, Anna Cichońska, Mika Tiainen, Harri Koskela, Kristian Nybo, Valtteri Mäkelä, Jussi Nokso-Koivisto, Kati Kristiansson, Markus Perola, Veikko Salomaa, Pekka Jousilahti, Annamari Lundqvist, Antti J. Kangas, Pasi Soininen, Jeffrey C. Barrett, Peter Würtz
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
The authors report a systematic analyses of blood biomarkers for metabolism against the whole spectrum of diseases in 100,000 individuals and reveals a prominent role of numerous metabolic biomarkers as risk markers beyond heart disease and diabetes.
Externí odkaz:
https://doaj.org/article/c89fd57120ab4597ba0f4b23f68d1f68
Autor:
Joshua A. Bell, Tom G. Richardson, Qin Wang, Eleanor Sanderson, Tom Palmer, Venexia Walker, Linda M. O'Keeffe, Nicholas J. Timpson, Anna Cichonska, Heli Julkunen, Peter Würtz, Michael V. Holmes, George Davey Smith
Publikováno v:
The Lancet Regional Health. Europe, Vol 21, Iss , Pp 100457- (2022)
Summary: Background: The direct effects of general adiposity (body mass index (BMI)) and central adiposity (waist-to-hip-ratio (WHR)) on circulating lipoproteins, lipids, and metabolites are unknown. Methods: We used new metabolic data from UK Bioban
Externí odkaz:
https://doaj.org/article/0109e225c9814daebc7a73d4d765b914
Autor:
Courtney J Smith, Nasa Sinnott-Armstrong, Anna Cichońska, Heli Julkunen, Eric B Fauman, Peter Würtz, Jonathan K Pritchard
Publikováno v:
eLife, Vol 11 (2022)
Pleiotropy and genetic correlation are widespread features in genome-wide association studies (GWAS), but they are often difficult to interpret at the molecular level. Here, we perform GWAS of 16 metabolites clustered at the intersection of amino aci
Externí odkaz:
https://doaj.org/article/93c24e8d6a9e4e24a0498f5ad88bc407
Autor:
Emmi Tikkanen, Vilma Jägerroos, Michael V. Holmes, Naveed Sattar, Mika Ala‐Korpela, Pekka Jousilahti, Annamari Lundqvist, Markus Perola, Veikko Salomaa, Peter Würtz
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 23 (2021)
Background Peripheral artery disease (PAD) and coronary artery disease (CAD) represent atherosclerosis in different vascular beds. We used detailed metabolic biomarker profiling to identify common and discordant biomarkers and clarify pathophysiologi
Externí odkaz:
https://doaj.org/article/dac13f26ed3f4657be68171482bb8f6f
Autor:
Heli Julkunen, Anna Cichońska, P Eline Slagboom, Peter Würtz, Nightingale Health UK Biobank Initiative
Publikováno v:
eLife, Vol 10 (2021)
Biomarkers of low-grade inflammation have been associated with susceptibility to a severe infectious disease course, even when measured prior to disease onset. We investigated whether metabolic biomarkers measured by nuclear magnetic resonance (NMR)
Externí odkaz:
https://doaj.org/article/202138e4a1de4a13a16089e47b5a1e98
Autor:
Joris Deelen, Johannes Kettunen, Krista Fischer, Ashley van der Spek, Stella Trompet, Gabi Kastenmüller, Andy Boyd, Jonas Zierer, Erik B. van den Akker, Mika Ala-Korpela, Najaf Amin, Ayse Demirkan, Mohsen Ghanbari, Diana van Heemst, M. Arfan Ikram, Jan Bert van Klinken, Simon P. Mooijaart, Annette Peters, Veikko Salomaa, Naveed Sattar, Tim D. Spector, Henning Tiemeier, Aswin Verhoeven, Melanie Waldenberger, Peter Würtz, George Davey Smith, Andres Metspalu, Markus Perola, Cristina Menni, Johanna M. Geleijnse, Fotios Drenos, Marian Beekman, J. Wouter Jukema, Cornelia M. van Duijn, P. Eline Slagboom
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
Biomarkers that predict mortality are of interest for clinical as well as research applications. Here, the authors analyze metabolomics data from 44,168 individuals and identify key metabolites independently associated with all-cause mortality risk.
Externí odkaz:
https://doaj.org/article/6923daf567204a5eb33b751c0974e159
Autor:
Artika P. Nath, Scott C. Ritchie, Sean G. Byars, Liam G. Fearnley, Aki S. Havulinna, Anni Joensuu, Antti J. Kangas, Pasi Soininen, Annika Wennerström, Lili Milani, Andres Metspalu, Satu Männistö, Peter Würtz, Johannes Kettunen, Emma Raitoharju, Mika Kähönen, Markus Juonala, Aarno Palotie, Mika Ala-Korpela, Samuli Ripatti, Terho Lehtimäki, Gad Abraham, Olli Raitakari, Veikko Salomaa, Markus Perola, Michael Inouye
Publikováno v:
Genome Biology, Vol 18, Iss 1, Pp 1-15 (2017)
Abstract Background Immunometabolism plays a central role in many cardiometabolic diseases. However, a robust map of immune-related gene networks in circulating human cells, their interactions with metabolites, and their genetic control is still lack
Externí odkaz:
https://doaj.org/article/e180785c8f2d4968ab0cf6652e950915
Autor:
Scott C Ritchie, Johannes Kettunen, Marta Brozynska, Artika P Nath, Aki S Havulinna, Satu Männistö, Markus Perola, Veikko Salomaa, Mika Ala-Korpela, Gad Abraham, Peter Würtz, Michael Inouye
Publikováno v:
PLoS ONE, Vol 14, Iss 10, p e0223692 (2019)
BackgroundGlycA is a nuclear magnetic resonance (NMR) spectroscopy biomarker that predicts risk of disease from myriad causes. It is heterogeneous; arising from five circulating glycoproteins with dynamic concentrations: alpha-1 antitrypsin (AAT), al
Externí odkaz:
https://doaj.org/article/5ceac96a58344eb8880965da4ef607d4
Autor:
Johannes Kettunen, Ayşe Demirkan, Peter Würtz, Harmen H.M. Draisma, Toomas Haller, Rajesh Rawal, Anika Vaarhorst, Antti J. Kangas, Leo-Pekka Lyytikäinen, Matti Pirinen, René Pool, Antti-Pekka Sarin, Pasi Soininen, Taru Tukiainen, Qin Wang, Mika Tiainen, Tuulia Tynkkynen, Najaf Amin, Tanja Zeller, Marian Beekman, Joris Deelen, Ko Willems van Dijk, Tõnu Esko, Jouke-Jan Hottenga, Elisabeth M van Leeuwen, Terho Lehtimäki, Evelin Mihailov, Richard J. Rose, Anton J.M. de Craen, Christian Gieger, Mika Kähönen, Markus Perola, Stefan Blankenberg, Markku J. Savolainen, Aswin Verhoeven, Jorma Viikari, Gonneke Willemsen, Dorret I. Boomsma, Cornelia M. van Duijn, Johan Eriksson, Antti Jula, Marjo-Riitta Järvelin, Jaakko Kaprio, Andres Metspalu, Olli Raitakari, Veikko Salomaa, P. Eline Slagboom, Melanie Waldenberger, Samuli Ripatti, Mika Ala-Korpela
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
Circulating metabolites reflect human health and disease. Here, Kettunen et al. perform a genome-wide association study on 123 circulating metabolic traits and identify novel genetic loci influencing systemic metabolism. They also link new molecular
Externí odkaz:
https://doaj.org/article/efa9e82fc86e4339bfe2f9945de63686
Autor:
Francine Z. Marques, Priscilla R. Prestes, Sean G. Byars, Scott C. Ritchie, Peter Würtz, Sheila K. Patel, Scott A. Booth, Indrajeetsinh Rana, Yosuke Minoda, Stuart P. Berzins, Claire L. Curl, James R. Bell, Bryan Wai, Piyush M. Srivastava, Antti J. Kangas, Pasi Soininen, Saku Ruohonen, Mika Kähönen, Terho Lehtimäki, Emma Raitoharju, Aki Havulinna, Markus Perola, Olli Raitakari, Veikko Salomaa, Mika Ala‐Korpela, Johannes Kettunen, Maree McGlynn, Jason Kelly, Mary E. Wlodek, Paul A. Lewandowski, Lea M. Delbridge, Louise M. Burrell, Michael Inouye, Stephen B. Harrap, Fadi J. Charchar
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 6, Iss 6 (2017)
BackgroundCardiac hypertrophy increases the risk of developing heart failure and cardiovascular death. The neutrophil inflammatory protein, lipocalin‐2 (LCN2/NGAL), is elevated in certain forms of cardiac hypertrophy and acute heart failure. Howeve
Externí odkaz:
https://doaj.org/article/f5430b2a41554e029fc2eb74411dd1ef