Zobrazeno 1 - 10
of 310
pro vyhledávání: '"Peter W, Andrews"'
Autor:
Ivana, Barbaric, Peter W, Andrews, Halliwell, J.A., Frith, T.J.R., Laing, O., Price, C.J., Bower, O.J., Stavish, T., Gokhale, P.J., Hewitt, Z., El-Khamisy, Sherif
Yes
Human pluripotent stem cells (PSCs) are subject to the appearance of recurrent genetic variants on prolonged culture. We have now found that, compared with isogenic differentiated cells, PSCs exhibit evidence of considerably more DNA damage
Human pluripotent stem cells (PSCs) are subject to the appearance of recurrent genetic variants on prolonged culture. We have now found that, compared with isogenic differentiated cells, PSCs exhibit evidence of considerably more DNA damage
Externí odkaz:
http://hdl.handle.net/10454/18013
Autor:
Ingrid M. Saldana-Guerrero, Luis F. Montano-Gutierrez, Katy Boswell, Christoph Hafemeister, Evon Poon, Lisa E. Shaw, Dylan Stavish, Rebecca A. Lea, Sara Wernig-Zorc, Eva Bozsaky, Irfete S. Fetahu, Peter Zoescher, Ulrike Pötschger, Marie Bernkopf, Andrea Wenninger-Weinzierl, Caterina Sturtzel, Celine Souilhol, Sophia Tarelli, Mohamed R. Shoeb, Polyxeni Bozatzi, Magdalena Rados, Maria Guarini, Michelle C. Buri, Wolfgang Weninger, Eva M. Putz, Miller Huang, Ruth Ladenstein, Peter W. Andrews, Ivana Barbaric, George D. Cresswell, Helen E. Bryant, Martin Distel, Louis Chesler, Sabine Taschner-Mandl, Matthias Farlik, Anestis Tsakiridis, Florian Halbritter
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-25 (2024)
Abstract Early childhood tumours arise from transformed embryonic cells, which often carry large copy number alterations (CNA). However, it remains unclear how CNAs contribute to embryonic tumourigenesis due to a lack of suitable models. Here we empl
Externí odkaz:
https://doaj.org/article/869f81138e26465185ec2a1246dd0cf6
Autor:
Dylan Stavish, Charlotta Böiers, Christopher Price, Thomas J. R. Frith, Jason Halliwell, Ingrid Saldaña-Guerrero, Jason Wray, John Brown, Jonathon Carr, Chela James, Ivana Barbaric, Peter W. Andrews, Tariq Enver
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Application of pluripotent cells in regenerative medicine requires an understanding of how they exit pluripotency. Here the authors demonstrate support for the idea that pluripotency exit involves pluripotent intermediates that exhibit lineage bias b
Externí odkaz:
https://doaj.org/article/49cf589d5cb741e6a087de76d2e33465
Autor:
Oliver Thompson, Ferdinand von Meyenn, Zoe Hewitt, John Alexander, Andrew Wood, Richard Weightman, Sian Gregory, Felix Krueger, Simon Andrews, Ivana Barbaric, Paul J. Gokhale, Harry D. Moore, Wolf Reik, Marta Milo, Serena Nik-Zainal, Kosuke Yusa, Peter W. Andrews
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Mutations in human pluripotent stem cells (PSC) and whether any form during culture prior to use in a human clinical context are a concern. Here, the authors use hPSCs derived to cGMP standards and show they have low mutation rates after culture, not
Externí odkaz:
https://doaj.org/article/6f55e007701f4013b3a7b971436b8888
Autor:
Jing Zhang, Adam J. Hirst, Fuyu Duan, Hui Qiu, Rujin Huang, Ying Ji, Lufeng Bai, Fengzhi Zhang, Darren Robinson, Mark Jones, Le Li, Peizhe Wang, Peng Jiang, Peter W. Andrews, Ivana Barbaric, Jie Na
Publikováno v:
Stem Cell Reports, Vol 12, Iss 3, Pp 557-571 (2019)
Summary: Human pluripotent stem cells (hPSCs) are susceptible to numerical and structural chromosomal alterations during long-term culture. We show that mitotic errors occur frequently in hPSCs and that prometaphase arrest leads to very rapid apoptos
Externí odkaz:
https://doaj.org/article/2877817865664220ae458e5a1dea7b8c
Autor:
Peter W. Andrews, Ivana Barbaric, Nissim Benvenisty, Jonathan S. Draper, Tenneille Ludwig, Florian T. Merkle, Yoji Sato, Claudia Spits, Glyn N. Stacey, Haoyi Wang, Martin F. Pera
Publikováno v:
Cell Stem Cell. 29:1624-1636
It is well established that human pluripotent stem cells (hPSCs) can acquire genetic and epigenetic changes during culture in vitro. Given the increasing use of hPSCs in research and therapy and the vast expansion in the number of hPSC lines availabl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fac4cdee26d7c0b797dbccac88af902f
https://doi.org/10.1016/j.stem.2022.11.006
https://doi.org/10.1016/j.stem.2022.11.006
Autor:
James O.S. Hackland, Tom J.R. Frith, Oliver Thompson, Ana Marin Navarro, Martin I. Garcia-Castro, Christian Unger, Peter W. Andrews
Publikováno v:
Stem Cell Reports, Vol 9, Iss 4, Pp 1043-1052 (2017)
Defects in neural crest development have been implicated in many human disorders, but information about human neural crest formation mostly depends on extrapolation from model organisms. Human pluripotent stem cells (hPSCs) can be differentiated into
Externí odkaz:
https://doaj.org/article/aff627b153154ab99cd03d0c5086d294
Assessing the Safety of Human Pluripotent Stem Cells and Their Derivatives for Clinical Applications
Autor:
Peter W. Andrews, Uri Ben-David, Nissim Benvenisty, Peter Coffey, Kevin Eggan, Barbara B. Knowles, Andras Nagy, Martin Pera, Benjamin Reubinoff, Peter J. Rugg-Gunn, Glyn N. Stacey
Publikováno v:
Stem Cell Reports, Vol 9, Iss 1, Pp 1-4 (2017)
Pluripotent stem cells may acquire genetic and epigenetic variants during culture following their derivation. At a conference organized by the International Stem Cell Initiative, and held at The Jackson Laboratory, Bar Harbor, Maine, October 2016, pa
Externí odkaz:
https://doaj.org/article/b5251a18ddb241f29499514e11c852b2
Autor:
Henrik Leffers, Ewa Rajpert-De Meyts, Niels E. Skakkebaek, Peter W. Andrews, Harry D. Moore, Lise Mette Gjerdrum, Søren Brunak, Peter E. Huber, Amir Abdollahi, Christian Schwager, Neil J. Harrison, Ludmila Ruban, Daniel Edsgard, Agnieszka Sierakowska Juncker, Marlene Dalgaard, Kristian Almstrup, Si Brask Sonne
Supplementary Figure 2 from Analysis of Gene Expression Profiles of Microdissected Cell Populations Indicates that Testicular Carcinoma In situ Is an Arrested Gonocyte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::547c602239dd7afad5c654a64e4b9bb4
https://doi.org/10.1158/0008-5472.22378791.v1
https://doi.org/10.1158/0008-5472.22378791.v1
Autor:
Ragnhild A. Lothe, Peter W. Andrews, Olli Kallioniemi, Gunnar Brunborg, Nur Duale, Sophie D. Fosså, Vera M. Abeler, Jahn M. Nesland, Outi Monni, Guro E. Lind, Rolf I. Skotheim
Supplementary Table 4 from Differentiation of Human Embryonal Carcinomas In vitro and In vivo Reveals Expression Profiles Relevant to Normal Development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16672058de6add0af6f868b9acff4434
https://doi.org/10.1158/0008-5472.22363776.v1
https://doi.org/10.1158/0008-5472.22363776.v1